云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(30830048)

国家自然科学基金(30830048): 作品数：14被引量：22H指数：3; 导出分析报告; 相关作者：张宏权唐岩战军马博牛苗苗更多>>; 相关机构：北京大学中国医学科学院北京协和医学院第三军医大学北京大学口腔医院更多>>; 相关期刊：《Frontiers of Medicine》《中国科学：生命科学》《Science China(Life Sciences)》《解剖学报》更多>>; 相关主题：DLIKINN-免疫印迹法CORRELATES更多>>; 相关领域：医药卫生生物学理学机械工程更多>>

细胞分裂周期相关蛋白7通过增强细胞增殖和干性促进人乳腺癌进程被引量：2: 《解剖学报》2020年第6期888-896,共9页杨得草刘程马集王梦远战军张宏权; 国家自然科学基金(81230051,81472734,31170711,81321003,81773199,30830048);科技部专项基金(2016YFC1302103,2015CB553906);北京市自然科学基金(7120002)。; 目的探讨细胞分裂周期相关蛋白7(CDCA7)在人类乳腺癌中的相关功能及潜在的作用机制。方法通过癌症和肿瘤基因图谱(TCGA)数据库分析检索出不同乳腺癌亚型差异表达基因,找到在基底型乳腺癌中高表达基因,在这些基因中找到CDCA7,通过临床患...; 关键词：细胞分裂周期相关蛋白7 Basal-like/luminal乳腺癌干细胞 Β-连环蛋白流式细胞术人

C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision被引量：2: 《Science China(Life Sciences)》2019年第9期1229-1242,共14页Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang; supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z;a grant from the National Natural Science Foundation of China (81773199) to J.Z; Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...; 关键词：C1orf106 BASAL-LIKE LUMINAL PROGENITOR breast cancer ELF5 GATA3

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma被引量：2: 《Frontiers of Medicine》2019年第4期482-491,共10页Wenjing Wang Shigang Ding Hejun Zhang Jun Li Jun Zhan Hongquan Zhang; This study was supported by grants from the Ministry of Science and Technology ofChina (Nos. 2016YFC1302103,2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (Nos. 81230051, 81472734, 31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (No. 7120002);the 111 Project of the Ministry of Education, Peking University (Nos. BMU20120314 and BMU20130364);and the Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang.; LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer. However, the relationship between LGR6 expression in patients and clinicopathological factors remains uncl...; 关键词：LGR6 COLON ADENOCARCINOMA IMMUNOHISTOCHEMISTRY PROGNOSIS

Kindlin-1和Kindlin-2的差异表达与食管癌的进程及流行病学特点的相关性被引量：3: 《中国科学：生命科学》2018年第1期93-101,共9页王鹏战军宋佳桂王允玲方伟岗刘芝华张宏权; 中国科技部基金(批准号：2016YFC1302103,2015CB553906,2013CB910501); 国家自然科学基金(批准号：81230051,81472734,31170711,81321003,81301802,30830048); 北京自然科学基金(批准号：7120002); 北京大学教育部111项目(批准号：BMU20120314,BMU20130364); 北京教育局领导学科项目资助; 食管癌是中国最致命的恶性肿瘤之一,但其病因和危险因素的分子机制仍不清楚.整合素相互作用蛋白Kindlin-1和Kindlin-2可以激活跨膜受体整合素,调节肿瘤细胞的生长、侵袭和转移.本研究首次发现,在中国食管癌患者中,Kindlin-1和Kindlin-2...; 关键词：Kindlin-1 Kindlin-2 食管癌流行病学

Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology被引量：1: 《Science China(Life Sciences)》2017年第11期1214-1222,共9页peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang; supported by the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906. 2013CB910501);the National Natural Science Foundation of China (81230051, 81472734, 31170711, 81321003, 81301802, 30830048);Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU20120314, BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang; Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that a...; 关键词：Kindlin-l Kindlin-2 esophageal cancer EPIDEMIOLOGY

Depletion of Kindlin-2 induces cardiac dysfunction in mice被引量：1: 《Science China(Life Sciences)》2016年第11期1123-1130,共8页Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang; supported by the Ministry of Science and Technology of China(2015CB553906,2013CB910501);the National Natural Science Foundation of China(81500180,81230051,81472734,31170711,81321003,30830048);Beijing Natural Science Foundation(7120002);the 111 Project of the Ministry of Education,Peking University(BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang; Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated ca...; 关键词：Kindlin-2 depletion myocardial hypertrophy cardiac dysfunction MOUSE

Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm被引量：1: 《Science China(Life Sciences)》2015年第5期432-441,共10页ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan; supported by the National Natural Science Foundation of China(81301802,81230051,30830048,31170711);Grant of Ministry of Science and Technology of China(2013CB910501,2010CB912203,2010CB529402);Program for Introducing Talents of Discipline to Universities(111 Project)of Ministry of Education;Beijing Natural Science Foundation(7120002);Peking University grants(BMU20120314,BMU20130364,BMU20130373);a Leading Academic Discipline Project of Beijing Education Bureau; Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Ki...; 关键词：Kindlin- 1 epithelial tissue ECTODERM ENDODERM embryo

Kindlin-2 expression in adult tissues correlates with their embryonic origins被引量：8: 《Science China(Life Sciences)》2014年第7期690-697,共8页ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan; supported by the National Natural Science Foundation of China (81301802,81230051,30830048,81321003,31170711);Ministry of Science and Technology of China (2013CB910501,2010CB912203,2010CB529402);Program of Introducing Talents of Discipline to Universities of Ministry of Education;Beijing Natural Science Foundation (7120002);Peking University (BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau; Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tiss...; 关键词：Kindlin-2 germinal layers migration EMBRYO

肿瘤细胞成瘤模型的建立与制片的体会: 《解剖学杂志》2013年第6期1129-1131,共3页瞧% 毕振伍战军张宏权; 教育部博士点基金（20100001110046）;国家自然科学基金（30830048）; 裸鼠体内成瘤实验是检验肿瘤细胞系成瘤能力的金标准，通过培养肿瘤细胞株建立裸鼠荷瘤模型是研究肿瘤生长、转移生物学特性及其分子调控机制，以及寻找治疗新药、新方法的重要手段。目前用于建立模型的肿瘤细胞株种类较多，如大肠癌、...; 关键词：肿瘤细胞系成瘤能力荷瘤模型制片肿瘤细胞株分子调控机制生物学特性成瘤实验

kindlin-1在人牙龈上皮的分布特点及其临床意义: 《解剖学报》2013年第5期641-645,共5页谢婷婷梅芳钟金晟唐岩张宏权; 国家自然科学基金资助项目(30830048);教育部博士点基金(20100001110046); 目的探讨kindlin-1在人健康牙龈上皮与慢性炎症性牙龈上皮分布特点的差异,从而建立kindlin-1与牙周疾病的临床相关性。方法应用免疫组织化学和免疫印迹法,分别检测10例正常牙龈上皮以及8例慢性炎症性牙龈上皮中kindlin-1的分布。结果免...; 关键词：kindlin-1 牙龈上皮免疫组织化学免疫印迹法人

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