国家重点基础研究发展计划(2011CB606203)

作品数:17被引量:95H指数:5
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相关作者:高长有姚远李友良胡巧玲张雨菲更多>>
相关机构:浙江大学合肥工业大学中国科学院更多>>
相关期刊:《材料科学与工程学报》《Regenerative Biomaterials》《Science China Chemistry》《化学进展》更多>>
相关主题:PLGA成骨分化HYDROXYAPATITECELL_ADHESIONFIBRONECTIN更多>>
相关领域:理学医药卫生生物学一般工业技术更多>>
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Enhanced electrochemical stimuli multilayers based on a ferrocene-containing polymer被引量:1
《Science Bulletin》2015年第10期936-942,I0008,共8页孙一新 任科峰 常国勋 赵义秀 刘湘圣 计剑 
supported by the National Natural Science Foundation of China(21174126,51333005,21374095);the National Basic Research Program of China(2011CB606203);Research Fund for the Doctoral Program of Higher Education of China(20110101110037,20120101130013);the Qianjiang Excellence Project of Zhejiang Province(2013R10035);International Science&Technology Cooperation Program of China(2014DFG52320)
Based on the noncovalent functionalization of ferrocene-grafted polyethylenimine (PEI-Fc) and carbon nanotubes (CNTs), CNT bundles are exfoliated by PEI-Fc solution and thus form stable compounds PEI-Fc@CNTs, whic...
关键词:Layer-by-layer assembly Stiffness Ferrocene Carbon nanotubes Electrochemical stimuli 
羟基磷灰石涂层表面蛋白质吸附研究及其对细胞黏附和成骨分化的影响被引量:5
《科学通报》2015年第15期1420-1420,共1页吴赛 刘宣勇 高长有 
国家重点基础研究发展计划(2011CB606203);国家自然科学基金(21434006,21374097)资助
通过等离子体喷涂的方法在纯钛表面修饰羟基磷灰石涂层,可有效促进成骨分化并加速骨再生.生物材料表面吸附的蛋白质对后续细胞行为起着至关重要的作用,然而其潜在机理还有待研究和证实.本研究检测了羟基磷灰石涂层(HA-Ti)和纯钛表面...
关键词:成骨分化 羟基磷灰石涂层 等离子体喷涂 细胞黏附 吸附研究 细胞行为 生物材料 纯钛 表面蛋白质 表面吸附 
Role of adsorbed proteins on hydroxyapatite-coated titanium in osteoblast adhesion and osteogenic differentiation被引量:1
《Science Bulletin》2015年第7期691-700,M0003,共11页吴赛 刘宣勇 高长有 
supported by the National Basic Research Program of China(2011CB606203);the National Natural Science Foundation of China(21434006,21374097)
The method of plasma-spray coating of hy- droxyapatite (HA) onto pure titanium has been demon- strated to be effective to enhance the osteogenic differentiation and accelerate bone regeneration. Yet it is still a bi...
关键词:HYDROXYAPATITE IMPLANTS Proteinadsorption FIBRONECTIN Bone morphogeneticprotein - Mesenchymal stem cells 
Effect of porosities of bilayered porous scaffolds on spontaneous osteochondral repair in cartilage tissue engineering被引量:25
《Regenerative Biomaterials》2015年第1期9-19,共11页Zhen Pan Pingguo Duan Xiangnan Liu Huiren Wang Lu Cao Yao He Jian Dong Jiandong Ding 
This work was supported by Chinese Ministry of Science and Technology(973 Programs No.2009CB930000 and No.2011CB606203);National Science Foundation of China(Grant No.21034002,31170925,and 51273046);Science and Technology Developing Foundation of Shanghai(Grant No.13XD1401000);Shanghai International Science and Technology Partnership Program(No.11540702700).
Poly(lactide-co-glycolide)-bilayered scaffolds with the same porosity or different ones on the two layers were fabricated,and the porosity effect on in vivo repairing of the osteochondral defect was examined in a comp...
关键词:bilayered scaffold POROSITY mesenchymal stem cell osteochondral defect PLGA cartilage tissue engineering 
Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker被引量:3
《Science China Chemistry》2014年第4期645-653,共9页SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong 
supported by the National Natural Science Foundation of China(21034002,91127028,51273046);the Ministry of Science and Technology of China(2011CB606203);the Science and Technology Development Foundation of Shanghai(13XD1401000)
Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photol...
关键词:biomaterials HYDROGELS MICROPATTERN MACROMONOMER cell adhesion 
Adsorption of plasma proteins and fibronectin on poly(hydroxylethyl methacrylate) brushes of different thickness and their relationship with adhesion and migration of vascular smooth muscle cells被引量:2
《Regenerative Biomaterials》2014年第1期17-25,共9页Jun Deng Tanchen Ren Jiyu Zhu Zhengwei Mao Changyou Gao 
This study is financially supported by the National Basic Research Program of China(2011CB606203);the Natural Science Foundation of China(21374097 and 51120135001).
The surface-grafted poly(hydroxylethyl methacrylate)(PHEMA)molecules were demonstrated to show a brush state regardless of their molecular length(molecular weight).Adsorption of proteins from 10%fetal bovine serum(FBS...
关键词:poly(hydroxylethyl methacrylate) smooth muscle cells protein adsorption MIGRATION 
Biological identity of nanomaterials:Opportunities and challenges被引量:3
《Science China Chemistry》2013年第11期1533-1541,共9页DENG Jun YU DaHai GAO ChangYou 
financially supported by the National Natural Science Foundation of China(51120135001);the National Basic Research Program of China(2011CB606203);Ph.D.Programs Foundation of Ministry of Education of China(20110101130005);Open Project of State Key Laboratory of Supramolecular Structure and Materials(sklssm201303)
The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and thera...
关键词:NANOPARTICLES carriers cellular uptake protein corona 
Effects of L-lactic acid and D,L-lactic acid on viability and osteogenic differentiation of mesenchymal stem cells被引量:7
《Chinese Science Bulletin》2013年第20期2404-2412,1-3,共9页HE Yao WANG WeiRan DING JianDong 
supported by the National Basic Research Program of China (2009CB930000, 2011CB606203);the National Natural Science Foundation of China (21034002, 91127028, 51273046)
Poly(lactic acid) (PLA) and other aliphatic polyesters containing the unit of lactic acid are very popular biodegradable materials. While the degradation products, lactic acids, have been worried to bring with negativ...
关键词:骨髓间充质干细胞 L-乳酸 成骨分化 细胞毒作用 能力 细胞毒性 可生物降解 生物相容性 
功能微粒材料的制备及其细胞作用研究(英文)
《化学进展》2013年第7期1061-1070,共10页毛峥伟 张元洪 李慧英 仝维鋆 高长有 
supports by the Natural Science Foundation of China (No.51120135001,20934003);the National Basic Research Program of China (No.2011CB606203);the Ph.D. Programs Foundation of Ministry of Education of China (No.20100101120034,20110101130005);“Qianjiang” outstanding researcher funding of Zhejiang Province (No.J20110541);Department of Education of Zhejiang Province (No.Z201018687)
随着纳米科学的迅速发展,越来越多的微粒材料被设计和制备出来,并应用于生物医学领域,取得了令人瞩目的进展和成就。近年来,我们课题组发展了一系列具备可控表面化学与结构、特定刺激响应性能和可控装载与释放性能的微粒材料,尤其是基...
关键词:胶体微粒 微胶囊 层层组装 细胞内吞 细胞功能 
负载PEO-b-PLL/DNA-TGF beta1粒子的PLGA/纤维蛋白凝胶复合支架的制备及其体外干细胞诱导分化性能被引量:1
《材料科学与工程学报》2013年第3期436-440,共5页杨军周 李博 马列 
国家973资助项目(2011CB606203);浙江省重大科技专项资助项目(2009C14003)
采用粒径分布在450~600μm的无规明胶颗粒为致孔剂制备乳酸-乙醇酸共聚物(PLGA)海绵体,以纤维蛋白凝胶为负载聚氧化乙烯-b-聚赖氨酸(PEO-b-PLL)/DNA粒子和骨髓间充质干细胞(BMSCs)的传递介质,通过负压将其导入PLGA多孔支架,在凝血酶和C...
关键词:PLGA 纤维蛋白胶 骨髓间充质干细胞 TGF-β1 分化 
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