《Science China(Life Sciences)》

作品数：4480被引量：17810H指数：41
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《Science China(Life Sciences)》
主办单位：Chinese Academy of Sciences;National Natural Science Foundating of China
最新期次：2025年4期更多>>
发文主题：GENEGENOMERICEIN_CHINAHUMAN更多>>
发文领域：生物学医药卫生农业科学自然科学总论更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis
《Science China(Life Sciences)》2025年第4期1042-1056,共15页Jinzhou Feng Shi Tang Xiaolin Yang Mengjie Zhang Zhizhong Li Shaoru Zhang Yongliang Han Yongmei Li Philippe P.Monnier Gang Yu Peng Zheng Cunjin Zhang Ke Xu Xinyue Qin 
supported by the National Science Foundation of China (81701191, 82301720);Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0973, CSTB2023NSCQMSX0183, CSTB2023NSCQ-BHX0214);China Postdoctoral Science Foundation (2022M722384, 2023MD734128);the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2020FYYX104);Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010);Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214);the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310);CQMU Program for Youth Innovation in Future Medicine (W0168)。
Although disturbances in the gut microbiome have been implicated in multiple sclerosis(MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes aff...
关键词：relapsing remitting multiple sclerosis gut microbiota 16S rRNA gene sequence untargeted metabolomics lipid metabolism biomarker 
Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis
《Science China(Life Sciences)》2025年第4期1057-1072,共16页Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang 
supported by the National Natural Science Foundation of China(32270603,31925021,82130022,92357305,82341226,32271232);the National Key Research and Development Program of China(2021YFF1201100,2018YFA0800701);the Fundamental Research Funds for the Central Universities(BMU2021YJ057)。
Adipogenesis is the healthy expansion of white adipose tissue(WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the body.Therefore,the identification of nove...
关键词：ADIPOGENESIS GPCRS trajectory inference 
BEND6 promotes RNA viruses'replication by inhibiting innate immune responses
《Science China(Life Sciences)》2025年第4期1073-1083,共11页Tong Chen Ling Ding Shaoyu Tu Huimin Sun Jiahui Zou Aotian Ouyang Meijun Jiang Yi Feng Meilin Jin Huanchun Chen Hongbo Zhou 
supported by the National Key Research and Development Program of China(2021YFD1800204);the National Natural Science Foundation of China(32025036);the Fundamental Research Funds for the Central Universities(2662023PY005);Hubei Hongshan Laboratory(2022hszd005);the earmarked fund for CARS-41;the Natural Science Foundation of Hubei Province(2021CFA016)。
Innate immunity serves as a crucial defense mechanism against invading pathogens,yet its negative regulatory network remains under explored.In this study,we identify BEN domain-containing protein 6(BEND6)as a novel ne...
关键词：innate immunity BEND6 RNAvirus IRF3 IFN-Β 
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells
《Science China(Life Sciences)》2025年第4期1084-1101,共18页Shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng Jun Xu 
supported by the National Key Research and Development Program of China(2021YFA1100300);the National Natural Science Foundation of China(32288102,32370843 and 32025006)Part of the data analysis was performed on the High Performance Computing Platform of the Center for Life Sciences,Peking University。
Human primed pluripotent stem cells are capable of generating all the embryonic lineages.However,their extraembryonic trophectoderm potentials are limited.It remains unclear how to expand their developmental potential...
关键词：trophectoderm lineages human primed pluripotent stem cells epigenetic regulation small molecules 
Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages
《Science China(Life Sciences)》2025年第4期1102-1117,共16页Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun Pang Yulong Yin Fengna Li 
supported by the National Natural Science Foundation of China(31972582);the STI 2030-Major Project(2023ZD04072);the Major Project of Changsha City(kh2401015);the Science and Technology Innovation Program of Hunan Province(2021RC4039);the Key Research and Development Program of Hunan Province(2022NK2026);the Youth Innovation Promotion Association CAS(Y202079);China Agriculture Research System of MOF and MARA(CARS-35)。
Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity,aging and metabolic disease.Since obese and lean pigs are ideal models for metabolic research.Here,we co...
关键词：skeletal muscle METABOLOME transcriptome biomarker metabolite intercellular communication lipid deposition pig model 
Bacterial indole-3-propionic acid inhibits macrophage IL-1βproduction through targeting methionine metabolism
《Science China(Life Sciences)》2025年第4期1118-1131,共14页Ziyi Han Jian Fu Aiyan Gong Wenkai Ren 
supported by the National Natural Science Foundation of China(32225047,U22A20510);Double First-Class Discipline Promotion Project(2023B10564001);National Center of Technology Innovation for Pigs(NCTIP-XD/B13);the Open Project Program of Sichuan Provincial Key Laboratory of Animal Disease-resistant Nutrition,Sichuan Agricultural University(SZ202301-02)。
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites,like indole derivatives from tryptophan.However,the direct role of these indole derivatives in macrophag...
关键词：IPA MACROPHAGE MAT2A IL-1Β 
Gut microbiota's role in high-altitude cognitive impairment:the therapeutic potential of Clostridium sp.supplementation
《Science China(Life Sciences)》2025年第4期1132-1148,共17页Wei Zhou Yongqiang Zhou Shikun Zhang Bin Li Zhong Li Zhijie Bai Dezhi Sun Chaoji Huangfu Ningning Wang Tiantian Xia Congshu Huang Lina Guan Xi Yang Yangyi Hu Pengfei Zhang Pan Shen Rui Wang Zhexin Ni Yue Gao 
supported by the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202207,Y.G.);the Young Elite Scientists Sponsorship Program by CAST(2021-QNRC1-03,W.Z.)。
Prolonged exposure to high-altitude environments may increase the risk of cognitive decline in young migrants.Recent studies suggest that hypobaric hypoxia-induced alterations in gut microbial composition could partly...
关键词：HIGH-ALTITUDE cognition impairment microbial mechanisms Clostridium sp. L-VALINE 
Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study
《Science China(Life Sciences)》2025年第4期1149-1157,共9页Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang 
supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0508200,2023ZD0508201);the National Natural Science Foundation of China(82100949,82470931);the Outstanding Young Investigator Award of Hunan Province(2022JJ10094);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC008)to J.H;the Intramural Research Program of the U.S.National Cancer Institute(NCI),National Institutes of Health(NIH)to D.A。
Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D),a comprehensive assessment of this relationship is currently lacking.We aimed to examine...
关键词：dietary carbohydrate type 2 diabetes prospective cohort study UK Biobank 
Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide
《Science China(Life Sciences)》2025年第4期1158-1173,共16页Xiaonan Wang Ning Zhou Xuejiao J.Gao Zijing Zhu Minmin Sun Qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu Lei Chen Jing Jiang Pengcheng Bu Lizeng Gao 
supported by the National Key R&D Program of China(2019YFA0709200);the National Natural Science Foundation of China(22121003,81930050)。
Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance.We unexpectedly discovered that the anti-H.pylori component in garlic is hydrogen polysulf...
关键词：hydrogen polysulfide G6PDH inactivation Helicobacter pylori polysulfide transformation gastric-adaptive 
Harnessing the Streptomyces-originating typeⅠ-E CRISPR/Cas system for efficient genome editing in Streptomyces
《Science China(Life Sciences)》2025年第4期1174-1182,共9页Yuhui Xie Xiaoyan Liu Tingting Wu Yunzi Luo 
supported by the National Key Research and Development Program of China(2018YFA0903300);the National Natural Science Foundation of China(32071426);the KeyArea Research and Development Program of Guangdong Province(2020B0303070002);the Haihe Laboratory of Sustainable Chemical Transformations(24HHWCSS00006)。
Since their discovery,CRISPR/Cas systems have significantly expanded the genetic toolbox,aiding in the exploration and enhanced production of natural products across various microbes.Among these,class 2 CRISPR/Cas sys...
关键词：genome editing type I-E CRISPR/Cas system STREPTOMYCES protospacer adjacent motif(PAM) identification natural product 
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