《Journal of Pharmaceutical Analysis》

作品数：1840被引量：2269H指数：16
导出分析报告
《Journal of Pharmaceutical Analysis》
主办单位：西安交通大学
最新期次：2024年11期更多>>
发文主题：PHARMACOKINETICSDETERMINATIONLC-MS/MSAPPLICATIONITS更多>>
发文领域：医药卫生理学自动化与计算机技术化学工程更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 被引期刊=Acta Pharmaceutica Sinica Bx
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches
《Journal of Pharmaceutical Analysis》2024年第11期1645-1660,共16页Ravi Maharjan Ki Hyun Kim Kyeong Lee Hyo-Kyung Han Seong Hoon Jeong 
supported by the Advance Production of Vaccine Raw Materials(Grant Nos.:20022404 and 20018168)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea);supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(Grant No.:NRF-2018R1A5A2023127);Dongguk University Research Fund of 2023(Grant No.:S-2023-G0001-00099)。
To enhance the efficiency of vaccine manufacturing,this study focuses on optimizing the microfluidic conditions and lipid mix ratios of messenger RNA-lipid nanoparticles(mRNA-LNP).Different mRNA-LNP formulations(n=24)...
关键词：Vaccine manufacturing Microfluidic device XGBoost Bayesian optimization Self-validated ensemble model 
Comparative study of trastuzumab modification analysis using mono/ multi-epitope affinity technology with LC-QTOF-MS
《Journal of Pharmaceutical Analysis》2024年第11期1675-1685,共11页Chengyi Zuo Jingwei Zhou Sumin Bian Qing Zhang Yutian Lei Yuan Shen Zhiwei Chen Peijun Ye Leying Shi Mao Mu Jia-Huan Qu Zhengjin Jiang Qiqin Wang 
supported by the National Natural Science Foundation of China(Grant Nos.:82373829,82273893,and 82173773);the Natural Science Foundation of Guangdong Province,China(Grant Nos.:2021A1515220099,and 2022A1515011576);the High-End Foreign Experts Project,China(Grant No.:G2021199005L);the Science and Technology Program of Guangdong Provincial Medical Products Administration,China(Grant Nos.:2023TDZ11,and 2022ZDB04).
Dynamic tracking analysis of monoclonal antibodies(mAbs)biotransformation in vivo is crucial,as certain modifications could inactivate the protein and reduce drug efficacy.However,a particular challenge(i.e.immune rec...
关键词：Monoclonal antibody Multi-epitope affinity technology Biotransformation analysis LC-QTOF-MS Breast cancer 
Epigenetic regulation of targeted ferroptosis: A new strategy for drug development
《Journal of Pharmaceutical Analysis》2024年第10期1418-1434,共17页Shengli Ouyang Zeyao Zeng Jieyi He Lianxiang Luo 
Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation.Epigenetic regulation plays a crucial role in the develop...
关键词：Treatment strategies EPIGENETICS Ferroptosis Epigenetic modifiers 
Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS^(2) library: Sishen formula as a case
《Journal of Pharmaceutical Analysis》2024年第10期1484-1495,共12页Lili Hong Wei Wang Shiyu Wang Wandi Hu Yuyang Sha Xiaoyan Xu Xiaoying Wang Kefeng Li Hongda Wang Xiumei Gao De-an Guo Wenzhi Yang 
This work was financially supported by National Natural Science Foundation of China(Grant No.:82192914);Tianjin Outstanding Youth Fund(Grant No.:23JCJQJC00030);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.:ZYYCXTD-C-202009).
Identifying the compound formulae-related xenobiotics in bio-samples is full of challenges.Conventional strategies always exhibit the insufficiencies in overall coverage,analytical efficiency,and degree of automation,...
关键词：Ultra-high performance liquid chromatography/ion-mobility quadrupole time-of-flight mass spectrometry(UHPLC/IM-QTOF-MS) Hybrid scan High-definition MS^(2)spectral library Sishen formula 
Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases
《Journal of Pharmaceutical Analysis》2024年第9期1282-1300,共19页Xiang Li Ru-Yi Chen Jin-Jin Shi Chang-Yun Li Yan-Jun Liu Chang Gao Ming-Rong Gao Shun Zhang Jian-Fei Lu Jia-Feng Cao Guan-Jun Yang Jiong Chen 
supported by the Natural Science Foundation of Zhejiang Province,China(Grant No.:LY24C190001);the General Scientific Research Project of Education of Zhejiang Province,China(Grant Nos.:Y202352559 and Y202147351);the Starting Research Fund of Ningbo University,China(Grant Nos.:421912073 and 422204123);the Student Research and Innovation Program of Ningbo University,China(Grant Nos.:2023SRIP1810 and 2023SRIP1804).
Jumonji domain-containing protein D3(JMJD3)is a 2-oxoglutarate-dependent dioxygenase that specifically removes transcriptional repression marks di-and tri-methylated groups from lysine 27 on histone 3(H3K27me2/3).The ...
关键词：JMJD3 INFLAMMATION Histone demethylation INHIBITOR 
Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles
《Journal of Pharmaceutical Analysis》2024年第9期1301-1319,共19页Dayue Liu Anning Yang Yulin Li Zhenxian Li Peidong You Hongwen Zhang Shangkun Quan Yue Sun Yaling Zeng Shengchao Ma Jiantuan Xiong Yinju Hao Guizhong Li Bin Liu Huiping Zhang Yideng Jiang 
supported by the National Natural Science Foundation of China(Grant Nos.:U21A20343,82160088,81870225,81870332,81700404,82271626,and 82260088);the Natural Science Foundation of Ningxia Autonomous Region,China(Grant Nos.:2020AAC02021,2020AAC02038,and 2022AAC05025);the Key Research and Development Projects in Ningxia Autonomous Region,China(Grant Nos.:2020BFH02003,2021BEG02033,2020BEG03008,and 2022BFH02013);the Basic Scientific Research Operating Expenses from the Public Welfare Research Institutes at the Central Level of the Chinese Academy of Medical Sciences,China(Grant No.:2019PT330002);the Ningxia Science and Technology Leading Talent Project,China(Grant No.:KJT2017007);the Natural Science Foundation of Hunan Province,China(Grant No.:2022JJ40698);the School-level Special Talent Launching Project of Ningxia Medical University,China(Grant No.:XT2018015);the Open Bidding for Selecting the Best Candidates Program of Ningxia Medical University,China(Grant No.:XJKF230106).
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic and medical fields. However, this drug faces a series of challenges when used to treat atherosclerosis cause...
关键词：HOMOCYSTEINE ATHEROSCLEROSIS Macrophage membrane Prussian blue nanoparticles Rosuvas tatin Gut microbes 
Spatially resolved metabolomics visualizes heterogeneous distribution of metabolites in lung tissue and the anti-pulmonary fibrosis effect of Prismatomeris connate extract被引量：1
《Journal of Pharmaceutical Analysis》2024年第9期1330-1346,共17页Haiyan Jiang Bowen Zheng Guang Hu Lian Kuang Tianyu Zhou Sizheng Li Xinyi Chen Chuangjun Li Dongming Zhang Jinlan Zhang Zengyan Yang Jiuming He Hongtao Jin 
supported by the National Natural Science Foundation of China(Grant No.:82074104);the Research Project of Clinical Toxicology Transformation from the Chinese Society of Toxicology,China(Grant No.:CST2021CT101);the Chinese Academy of Medical Science Innovation Fund for Medical Sciences,China(Grant Nos.:2017-I2M-1-011 and 2022-I2M-2-002).
Pulmonary fibrosis (PF) is a chronic progressive end-stage lung disease. However, the mechanisms underlying the progression of this disease remain elusive. Presently, clinically employed drugs are scarce for the treat...
关键词：Spatially resolved metabolomics Mass spectrometry imaging Network pharmacology Pulmonary fibrosis Prismatomeris connate extract 
Rapid toxicity characterization of Aconitum herbal medicines using perfusion nano-electrospray ionization mass spectrometry
《Journal of Pharmaceutical Analysis》2024年第9期1393-1395,共3页Chaofa Wei Liping Kang Yaqiu Zhao Li Zhou Xiang Li Shuanglong Wang Luqi Huang Zidong Qiu 
supported by the CACMS Innovation Fund(Grant Nos.:CI2021A05206,and CI2021A04504);the National Natural Science Foundation of China(Grant No.:82104380);the Fundamental Research Funds for the Central Public Welfare Research Institutes(Grant No.:ZZ14-YQ-047);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant Nos.:CI2023E002,and CI2023C039YGL).
Accurate analysis of the key substances in traditional Chinese medicines(TCMs)is the prerequisite and foundation for the quality evaluation and pharmacological substance research of TCMs[1].However,the extremely compl...
关键词：TCM FOUNDATION MEDICINES 
Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism
《Journal of Pharmaceutical Analysis》2024年第8期1222-1237,共16页Chu Zhang Gui Wang Xin Yin Lingshan Gou Mengyuan Guo Feng Suo Tao Zhuang Zhenya Yuan Yanan Liu Maosheng Gu Ruiqin Yao 
supported by the Natural Science Foundation for Young Scientists of China(Grant No.:82201545);the Natural Science Foundation of Jiangsu Province,China(Grant No.:BK20221221);the Practice Innovation Program of Jiangsu Province,China(Grant No.:KYCX21_2641);the Medical Science Foundation of Jiangsu Province,China(Grant No.:H2019007);the Key Medical Talents Training Project of Xuzhou,China(Grant No.:XWRCHT20220060);the Xuzhou“Pengcheng Talent”Youth Medical Reserve Talent Project,China(Grant No.:XWRCHT20220014);the Science and Technology Projects of Xuzhou,China(Grant No.:KC21061).
Intestinal dysbiosis and disrupted bile acid(BA)homeostasis are associated with obesity,but the precise mechanisms remain insufficiently explored.Hepatic protein phosphatase 1 regulatory subunit 3G(PPP1R3G)plays a piv...
关键词：PPP1R3G OBESITY Liver steatosis Gut microbiota Bile acid metabolism 
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
《Journal of Pharmaceutical Analysis》2024年第7期955-971,共17页Meihong Zhang Mengqin Guo Yue Gao Chuanbin Wu Xin Pan Zhengwei Huang 
funding from the National Natural Science Foundation of China(Grant No.:82104070);Guangdong Universities Keynote Regions Special Funded Project,China(Grant No.:2022ZDZX2002);China Postdoctoral Science Foundation Special Funded Project(Grant No.:2022T150268)。
Ferroptosis is a nonapoptotic form of cell death and differs considerably from the well-known forms of cell death in terms of cell morphology,genetics,and biochemistry.The three primary pathways for cell ferroptosis a...
关键词：Ferroptosis MECHANISMS Therapeutic targets NANOMEDICINES 
全选清除导出
共7页<1234567>
检索报告 对象比较 聚类工具 使用帮助 返回顶部