The treatment of intrahepatic cholangiocarcinoma(iCCA)has traditionally been limited to surgical resection or systemic therapy.The role of liver transplantation in the management of iCCA is a topic currently being exp...
Intrahepatic cholangiocarcinoma(iCCA)is a rare tumor that arises from second order or smaller bile ducts.Its incidence has been growing in the last couple of decades,in parallel with its mortality rates,both in Americ...
DS is supported by the Tisch Cancer Institute(Icahn School of Medicine at Mount Sinai),the F.Klion Award,i3 Genesis Award and the TCI Dev.Funds Award 2023.
Intrahepatic cholangiocarcinoma(iCCA)is an aggressive and heterogeneous biliary cancer with a poor prognosis and limited treatment options.The molecular pathogenesis of iCCA involves a highly complex process entailing...
Cholangiocarcinoma(CCA)grows within a highly desmoplastic microenvironment,exhibiting a continuous interconnection with the immune infiltrate,which is characterized by an abundance of immune cells,including natural ki...
Intrahepatic cholangiocarcinoma(ICCA)incidence has been rising in the last few decades.Currently,hepatic resection is the only curative treatment for ICCA,and there is a lack of evidence supporting the use of preopera...
Cholangiocarcinoma(CCA)is an extremely aggressive malignancy characterized by a very limited prognosis and scarce treatment options.The majority of patients are diagnosed at an advanced stage and do not qualify for po...
Liver transplantation has emerged as a potential therapeutic option for select patients with intrahepatic cholangiocarcinoma(iCCA)who are not amenable to curative resection.Recent studies have challenged the tradition...
International guidelines recommend six monthly ultrasounds as the primary surveillance tool for patients at risk of hepatocellular carcinoma(HCC).The dominant driver of liver disease in HCC surveillance populations is...
The proportion of hepatocellular carcinoma(HCC)cases due to NAFLD is expected to increase,paralleling the rise in NAFLD due to the obesity epidemic.Early detection is critical,as it potentially enables curative treatm...
Cholangiocarcinoma(CCA)is an extremely aggressive neoplasia,mostly because of diagnostic delay and lack of effective therapies.CCA is typically surrounded by a peculiar microenvironment that includes abundant desmopla...