《BIOCELL》

作品数：1065被引量：280H指数：4
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《BIOCELL》
主办单位：Tech Science Press
最新期次：2025年4期更多>>
发文主题：AUTOPHAGYAPOPTOSISOXIDATIVE_STRESSIMMUNECANCER更多>>
发文领域：医药卫生生物学理学农业科学更多>>
发文基金：国家自然科学基金中国博士后科学基金广东省自然科学基金广西壮族自治区自然科学基金更多>>
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Evaluating Oncogenic Drivers and Therapeutic Potential of the PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma: An Overview of Clinical Trials
《BIOCELL》2025年第4期539-562,共24页Ayda Baghery Saghchy Khorasani Mahda Delshad Mohammad-Javad Sanaei Atieh Pourbagheri-Sigaroodi Ali Pirsalehi Davood Bashash 
Hepatocellular carcinoma(HCC)is the most common primary liver tumor and the third leading cause of cancer-related mortality globally.The phosphatidylinositol-3 kinase(PI3K)/protein kinase B(AKT)/mammalian target of ra...
关键词：HCC PI3K AKT MTOR clinicaltrial 
In Search of New Pharmacological Targets:Beyond Carnosine’s Antioxidant,Anti-Inflammatory,and Anti-Aggregation Activities
《BIOCELL》2025年第4期563-578,共16页Giuseppe Carota Lucia Di Pietro Vincenzo Cardaci Anna Privitera Francesco Bellia Valentina DiPietro Giuseppe Lazzarino Barbara Tavazzi Angela Maria Amorini Giacomo Lazzarino Giuseppe Caruso 
Carnosine(β-alanyl-L-histidine)is a naturally occurring endogenous peptide widely distributed in excitable tissues,such as the heart and brain.Over the years,several beneficial effects of carnosine have been discusse...
关键词：CARNOSINE pharmacological targets nitric oxide TGF-β1 FRACTALKINE insulin-degrading enzyme N-METHYLTRANSFERASE energy metabolism 
Phospholipid Metabolism Reprogramming of Cancer Stem Cells and Its Impacts on Stemness
《BIOCELL》2025年第4期579-605,共27页Qing Wang Luyao Cai Shouyi Tang Dan Pan Zhen Wang Qianming Chen Yu Zhou Yingqiang Shen 
supported by grants from National Natural Science Foundation of China(81902784,81771086);by the Fund of Sichuan Provincial Department of science and technology(2024YFFK0393,2022YFS0039);the Research and Develop Program,West China Hospital of Stomatology,Sichuan University(LCYJ2023-DL-2,RD-02-202002);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-004)。
Cancer Stem Cells(CSCs)are cancer cells with self-renewal and tumorigenesis abilities.CSCs in tumor tissues are the leading cause of tumor progression,recurrence,and drug resistance.CSCs have distinct metabolic featur...
关键词：Neoplastic stem cells cancer stem cells PHOSPHOLIPIDS phosphatides METABOLISM 
Mechanistic Insights into N-Oleoylethanolamide-Mediated Hepatoprotection via PPAR-α
《BIOCELL》2025年第4期607-627,共21页Darya Ivashkevich Arina Ponomarenko Igor Manzhulo Inessa Dyuizen 
supported by the Russian Science Foundation(project 24-75-00072).
The high prevalence of obesity and associated nonalcoholic fatty liver disease(NAFLD)in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these p...
关键词：NAFLD liver inflammation N-Oleoylethanolamide OEA PPAR-Α 
Hyperthyroidism-Induced Lymphoid Cell Activation in the Lymph Nodes and Spleen of BALB/c Mice
《BIOCELL》2025年第4期629-646,共18页Maria Belen Rocco Clara Requena D’Alessio Valeria Giselle Sanchez Horacio Eduardo Romeo Maria Laura Barreiro Arcos 
Introduction:Hyperthyroidism is known to affect various physiological systems,including the immune system.Thyroid hormones(THs)play a crucial role in regulating immune function,and alterations in THs levels can lead t...
关键词：HYPERTHYROIDISM lymphoid organs lymphocytic activation MITOCHONDRIA reactive oxygen species 
Picropodophyllotoxin: A Natural Epimer Targeting STAT3 Phosphorylation and ROS-Mediated Apoptosis in Oral Squamous Cell Carcinoma Cells
《BIOCELL》2025年第4期647-663,共17页Jung-ⅡChae Ji-Hye Seo Goo Yoon Young-Joo Jeon Woo-Keun Kim 
supported by the Korea Institute of Toxicology(KIT)Research Program[No.2710008763(KK-2401-01)];the Korea Environmental Industry&Technology Institute(KEITI)through the Core Technology Development Project for Environmental Diseases Prevention and Management[No.2480000072(RS-2021-KE001705)]。
Background:Picropodophllotoxin(PPT),a principal component of Podophyllum hexandrum root,demonstrates various beneficial biological activities in multiple cancer types,including antitumor and antiproliferative properti...
关键词：Picropodophyllotoxin STAT3 ROS oral squamous cell carcinoma APOPTOSIS 
CLDN9 Levels Influence the Biological Activities of Cells in Gastric Cancer
《BIOCELL》2025年第4期664-679,共16页Jin Liu Xiu Zhang Xiao Hu Gaofeng Yuan Kai Chen 
supported by the Science and Technology Plan of Suqian City(Grant No.S202117).
Objective:This study examines the significance and functions of CLDN9 in gastric cancer(GC),intending to identify novel targets for diagnosis and treatment.Methods:CLDN9 expression in GC tissues and cell lines was inv...
关键词：Gastric cancer CLDN9 cell proliferation INVASION MIGRATION 
SLFN11 Deficiency-Induced Gemcitabine Resistance Is Overcome by Agents Targeting the DNA Damage Response in Pancreatic Cancer Cells
《BIOCELL》2025年第4期681-700,共20页Jae Hyeong Kim Yuna Youn Jin-Hyeok Hwang 
supported by the 8th AstraZeneca-KHIDI(Korea Health Industry Development Institute)oncology research program;a research grant was supported by AstraZeneca and by Grant No.02-2022-0020 from the Seoul National University Hospital(SNUBH)Research Fund.
Objectives:SLFN11(Schlafen-11)enhances sensitivity to DNA-damaging agents(DDAs)and DNA damage response(DDR)inhibitors in various cancer types.However,its function in pancreatic cancer(PC)remains largely unknown.This r...
关键词：SLFN11 DNA-damaging agents DNA damage response pancreatic cancer 
Regulation of Dendritic Cell Function by RFX5 through Interaction with HDAC2 and Its Mechanism in Pediatric Asthma
《BIOCELL》2025年第4期701-720,共20页Yahui Wu Tiansheng Dai Jingwen Qin Jian Guo Jitao Fan Jun Mei Xiaoli Li Fang Liu 
supported by the 2021 Jiangxi Provincial Department of Science and Technology Applied Research Cultivation Plan Project(No.20212BAG70005,Yahui Wu);2021 Science and Technology Special Project and Social Development Project in Ji’an City,Jiangxi Province(No.20211-025242,Yahui Wu).
Background:Dendritic cells(DCs)play a pivotal role in antigen presentation and regulating adaptive immune responses in asthma pathophysiology.However,the underlying molecular mechanisms remain incompletely understood....
关键词：ASTHMA regulatory factor X5(RFX5) dendritic cells(DCs) histone deacetylase 2(HDAC2) 
The Role of Linker Histone Mutation in Oncogenesis: Molecular Mechanism and Structural Impact
《BIOCELL》2025年第4期519-538,共20页Gege Liu Houfang Zhang Yunhui Peng 
supported by the National Natural Science Foundation of China(No.12205112);financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE(CCNU24JC012);supported by Natural Science Foundation of Wuhan(No.2024040801020302).
Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighte...
关键词：Linker histone H1 EPIGENETICS histone cancer mutations chromatin structure NUCLEOSOME 
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