supported by the National Key Research and Development Program of China(Grant number 2023YFC2606500);Huai'an City Innovation Service Capacity Building Program(Key Laboratory Construction)(Grant number HAP201906);Jiangsu Province 333 Project.
Pigs are vital genetic mixing vessels for human and avian influenza viruses because their tracheal epitheliums possess both sialic acidα-2,6-Gal andα-2,3-Gal receptors.Cross-species transmission of influenza A virus...
supported by Key-Area Research and Development Program of Guangdong Province,China(2022B1111010004,2021B1212040017);Basic Research Program of Guangzhou Municipal Science and Technology Bureau(SL2023A03J01074);Guangdong Provincial Highly Pathogenic Microorganism Science Data Center(2024B1212070013);Shenzhen Science and Technology Program(ZDSYS20230626091203007).
The increase in emerging and reemerging infectious diseases has underscored the need for the prompt monitoring of intact infectious viruses and the quick assessment of their infectivity.However,molecular techniques ca...
supported by The Key-Area Research and Development Program of Guangdong Province (2022B1111020006);The Medical Scientific Research Foundation of Guangdong Province, China, 2024 (A2024600). We thank all the participants in the study.
Q fever is a zoonotic disease caused by infection withCoxiella burnetii(C.burnetii).Due to its atypical symptoms and the absence of specific detection methods,Q fever is underdiagnosed commonly.Herein,we report a case...
supported by the National Natural Science Foundation of China(82272306 and 82072270);Shandong Provincial Natural Science Foundation(ZR2024MH017);Taishan Scholars Program(tstp20221142).
In 2022,a sharp rise in global cases of mpox virus(MPXV)led the World Health Organization(WHO)to declare it a public health emergency of international concern.However,progress in developing drugs targeting MPXV has be...
supported by the National Key Research and Development Program of China(2022YFC2304100 and 2021YFA1201003).
Viral infectious clones(ICs)serve as robust platforms for studying viral biology and screening antiviral agents using reverse genetics.However,the molecular profiles and complex limitations of human coronaviruses(HCoV...
funded by the National Natural Science Foundation of China(U2002219);The datasets generated or analyzed during the current study are available from the corresponding author on reasonable request;All the nucleotide sequences obtained in this study are available in the GenBank of National Center for Biotechnology Information with accession numbers OR805110-OR805127,OR792783-OR792797,OR793990-OR793998,and OR813910-OR813915.
Recently,there has been a continuous stream of reports on emerging tick-borne pathogens affecting humans.Qinghai Province,located in the northweastern region,is one of China’s major pastoral areas,providing a suitabl...
In the last century,global pandemics have been primarily driven by respiratory infections,which consistently rank among the top 20 causes of death worldwide.The coronavirus disease 2019(COVID-19)pandemic has underscor...
supported by the National Key Research and Development Program of China(2023YFA0913700);China Postdoctoral Science Foundation(2023 M732591);the Key R&D Program of Shandong Province,China(2022SFGC0102).
With the rapid advance in synthetic biology and the expanding field of synthetic genomics,the realization of a redesigned yeast genome has become an achievable milestone.Multiple eukaryotic chromosomes,meticulously de...
supported by the University of Chinese Academy of Sciences Education Foundation and the Bill&Melinda Gates Foundation(INV-008950)。
1.Introduction.The Immunization Agenda 2030 outlined the importance of capacity building for researchers,regulators and public health officials at national,regional and local levels in its multiple strategic prioritie...
financial support was received for the research,authorship,and/or publication of this article;funded by Nanjing Bioengineering(Gene)Technology Center for Medicines(2024YQFH01)。
Mpox is a zoonotic disease caused by the monkeypox virus(MPxV).Diagnosing and treating the disease has become a global health concern requiring close attention to its spread to non-endemic regions.Clinical diag-nosis ...