《Biosafety and Health》

作品数：290被引量：344H指数：7
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《Biosafety and Health》
主办单位：中华医学会
最新期次：2025年1期更多>>
发文主题：SARS-COVBIOSAFETYVIRUSINFECTIONBIO更多>>
发文领域：医药卫生农业科学生物学经济管理更多>>
发文基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Integrative single-cell and metagenomic analysis dissects SARS-CoV-2 shedding modes in human respiratory tract
《Biosafety and Health》2025年第1期5-16,共12页Xiangxing Jin Lili Ren Xianwen Ren Jianwei Wanag 
Science Fund for Creative Research Groups of the National Natural Science Foundation of China(82221004);the National Natural Science Foundation(81930063);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-12M-1-038);Changping Laboratory research fund.
It is crucial to understand how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)sheds in human respiratory tract,but this question remains elusive due to technical limitations.In this study,we integrated pu...
关键词：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Viral shedding RNA-Seq Single-cell analysis 
Genomic characteristics of 12 HBV-I strains in the 2020 national HBV serosurvey in China
《Biosafety and Health》2025年第1期17-25,共9页Qiudong Su Liping Shen Xiaoqi Guo Shuang Zhang Feng Qiu Shengli Bi Feng Wang 
supported by the National Key Research and Development Program of China(Grant No.2023YFC2306900).
Hepatitis B virus(HBV)is categorized into ten distinct genotypes(A-J),with over 4O subgenotypes identified to date.HBV genotype I(HBV-I),an inter-genotypic recombinant,has emerged during the evolution history of HBV.I...
关键词：Hepatitis B virus(HBV) Genotype I Homology analysis PreS/Smutations Evolutionary analysis 
Epidemiological characteristics of human adenovirus infections in China,2020-2023
《Biosafety and Health》2025年第1期26-32,共7页Chongyang Li Yitong Lin Naiying Mao Yixuan Gao Ying Liu Liwei Sun Hui Zhang Jin Xu Maozhong Li Feng Zhang Xiaoqing Liu Linqing Zhao Bing Zhu Ye Chen Min Mu Xiaoling Tian Hongmei Xu Chaoyang Huang Zhong Li Jing Xu Zhenguo Gao Yali Jin Chunyu Zhu Aili Cui Baicheng Xia Yan Zhang Zhen Zhu 
supported by the National Key R&D Program of China(2022YFC2305303).
To better understand the epidemiological characteristics of human adenovirus(HAdv)infections in China during and after the coronavirus disease 2019(COvVID-19)pandemic,respiratory specimens were collected from 17,562 e...
关键词：Respiratory infection Epidemiological characteristic Humana denovirus 
AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13
《Biosafety and Health》2025年第1期33-37,共5页Junwen Luan Annan Ming Wenbo Zhao Liyuan Zhang Leiliang Zhanag 
supported by the National Natural Science Foundation of China(82272306 and 82072270);the Taishan Scholars Program(tstp20221142).
Treatment of mpox virus(MPxV)is crucial for public health.However,research into drugs for MPxV has fallen behind,particularly in anticipation of sudden outbreaks.This study aimed to identify new inhibitors of Orthopox...
关键词：Mpox mpox virus (MPXV) F13 Tecovirimat Artificial intelligence(Al) 
Bibliometric analysis of flavivirus-host interactions and immune responses:Research hotspots and trends
《Biosafety and Health》2025年第1期38-43,共6页Yuxin Xiong Wenxin Fan Ying Wu 
supported by the National Key Research and Development Plan of China(2021YFC2300200);the National Natural Science Foundation of China(32122008).
Flaviviruses are zoonotic pathogens transmitted by infected mosquitoes and ticks,posing a persistent threat to global health.These infections lead to a diverse spectrum of diseases,broadly classified into two phenotyp...
关键词：Academic visualization BIBLIOMETRICS FLAVIVIRUS Immuneresponses 
Computational optimization of a pan-coronavirus fusion inhibitory peptide targeting spike's heptapeptide repeat region
《Biosafety and Health》2025年第1期44-58,共15页Peixiang Gao Shuo Liu Xiaojing Chi Xinhui Zhang Xiuying Liu Xuehua Yang Huarui Duan Jingya Zhou Weijin Huang Wei Yanag 
supported by the National Natural Science Foundation of China(U22A20553 and 82241064);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-038, 2022-I2M-1-021).
In the past two decades,highly pathogenic coronaviruses(CoVs),such as severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrom...
关键词：Coronaviruses(CoVs) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Fusion inhibitors Computational design 
Advances in the development of infectious clones of human coronaviruses and related applications
《Biosafety and Health》2025年第1期59-73,共15页Guanya Liu Ruixiao Tan Yiyi Wu Mengwei Wang Baoying Huang Wenjie Tan 
the National Key Research and Development Program of China(2022YFC2304101,2021YFA1201003).
Coronaviruses can infect humans,mammals,and birds,leading to respiratory,gastrointestinal,and neurological diseases.These viruses are significant zoonotic pathogens with nine known types capable of infecting humans.Th...
关键词：Human coronaviruses Reverse genetics Infectious clones APPLICATION 
Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics
《Biosafety and Health》2025年第1期74-82,共9页Shijin Wang Qing Yu Junfeng Zhou Wanshan Yang Yonggang Wang Haoran Guo Wei Wei 
supported in part by funding from the National Natural Science Foundation of China(32222005,82372226,and 82172246);the Open Project of Key Laboratory of Organ Regeneration and Transplantation,Ministry of Education,Program for JLU Science and Technology Innovative Research Team(2017TD-08);the Fundamental Research Funds for Central Universities.
Over the past decades,oncolytic viruses have emerged as prominent therapeutic agents with significant potential for anticancer treatment.Enteroviruses(EVs)have garnered particular attention due to their specific tropi...
关键词：Reverse genetics Enterovirus(EV) Oncolytic virus(Ov) PATHOGENESIS Tumor immunity 
Targeting anti-virulence factor strategies of bacterial pathogens
《Biosafety and Health》2025年第1期1-4,共4页Jiashu Li Tianyuan Jia Liang Yanag 
supported by the Science Technology and Innovation Commission of Shenzhen(JCYJ20210324115607021);the National Natural Science Foundation of China(32300068,32270196,91951204,32200155,32200053,and 32300060).
Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards,leading to millions of deaths each year.The evolution of bacterial virulence factors is mainly propelled by horizontal gene transf...
关键词：Irulence factors Horizontal gene transfer Anti-biofilm strategies Quorum-sensing(Qs) 
Antigenicity and genetic properties of an Eurasian avian-like H1N1 swine influenza virus in Jiangsu Province,China
《Biosafety and Health》2024年第6期319-326,共8页Fang He Huiyan Yu Liqi Liu Xiyan Li Yadong Xing Lei Yang Pengfei Yang Liguo Zhu Zi Li 
supported by the National Key Research and Development Program of China(Grant number 2023YFC2606500);Huai'an City Innovation Service Capacity Building Program(Key Laboratory Construction)(Grant number HAP201906);Jiangsu Province 333 Project.
Pigs are vital genetic mixing vessels for human and avian influenza viruses because their tracheal epitheliums possess both sialic acidα-2,6-Gal andα-2,3-Gal receptors.Cross-species transmission of influenza A virus...
关键词：Eurasian avian-like H1N1 swine influenza virus(EAH1N1 SIVs) Amino-acid sites ANTIGENICITY Drug resistance 
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