《Frigid Zone Medicine》

作品数：108被引量：20H指数：2
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《Frigid Zone Medicine》
主办单位：黑龙江省卫生健康发展研究中心
最新期次：2024年4期更多>>
发文主题：COLDCORONAEFFECTSCARDIOVASCULARHYPERTENSION更多>>
发文领域：医药卫生理学经济管理语言文字更多>>
发文基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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GDF11 restores the impaired function of EPCs-MA by promoting autophagy:GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy
《Frigid Zone Medicine》2024年第4期212-223,共12页Donghua Liu Yang Zhang Xin Liu Qihe Huang Xiaofang Zhang Rui Yang Yue Zhao Penghui Li Jiayi He Kexiao Zhang Zhenwei Pan Huiwen Liu Baofeng Yang 
the National Natural Science Foundation of China(81421063);China Postdoctoral Science Foundation(2016M591556);Natural Science Foundation of Heilongjiang Province of China(H2016008);Postdoctoral Science Foundation of Heilongjiang Province of China(LBH-Z15146);Research Project of the Health and Family Planning Commission of Heilongjiang Province(2016-166).
Objective:Our study aimed to assess the effects of Growth and differentiation factor 11(GDF11)on the function of endothelial progenitor cells in middle-age individuals(EPCs-MA)isolated from mouse bone marrow and to ex...
关键词：GDF11 endothelial progenitor cells autophagy lysosome pathway AGING 
ISG15 promotes M5-induced hacat cell proliferation through Wnt signaling in psoriasis
《Frigid Zone Medicine》2024年第4期224-232,共9页Xianqi Sun Yuzhen Li Huiwen Yu Jiaying Lin Chen Wang Quanlin Liu Bingxue Bai 
supported by the Natural Science Foundation of Heilongjiang Province(PL2024H107).
Objective:Psoriasis is a common chronic,recurrent,immune-mediated inflammatory skin disease,which tends to occur in cold areas.Its pathogenesis is currently unclear.This study aims to screen differentially expressed g...
关键词：PSORIASIS keratinocyte proliferation ISG15 Wnt signaling pathway 
Identification of hub genes and pathways in mouse with cold exposure
《Frigid Zone Medicine》2024年第4期233-241,共9页Xu Wang Hongbo Hu Ying Zhang 
Background:Cold exposure is linked to numerous diseases,yet the changes in key genes and pathways in mice under cold exposure remain unexplored.Understanding these alterations could offer insights into the mechanisms ...
关键词：cold exposure hub genes PATHWAY adipose tissue 
The function and effect on prognosis of ANXA2 in gastric cancer peritoneal metastasis patients in cold region
《Frigid Zone Medicine》2024年第4期242-251,共10页Shiyang Jin Longxu Liang Xiaoyi Huang Kuan Wang 
We are grateful to Haiyan Fund,Harbin Medical University Cancer Hospital(JJED2016-02);the financial support.The funding source had no role in the design,practice or analysis of this study.
Objective:Heilongjiang Province is part of the northern cold areas of China,where gastric cancer is one of the most common gastrointestinal malignancies.Peritoneal metastases(PM)are the leading cause of mortality amon...
关键词：Gastric cancer ANXA2 prognosis survival BIOINFORMATICS cold region 
Arthroscopic patellar denervation with microfracture for treating patellofemoral arthritis in cold weather conditions:a retrospective clinical analysis
《Frigid Zone Medicine》2024年第4期252-256,共5页Xinnan Ma Xin Zhang Yingkai Ma Yonghou Zhao Kai Liu 
supported by grants from the Natural Science Foundation of Heilongjiang Province of China(JQ2020H003);Heilongjiang Postdoctoral Fund(NO.LBH-Z23257);the Innovative Science Research Fund of Harbin Medical University(also known as Heilongjiang Provincial University's Project of Graduate Scientific Research Business Fees)(2022-KYYWF-0274);the Youth TCM scientific research Project of Heilongjiang Province TCM Administration(ZHY2024-283).
Objective:To evaluate the clinical efficacy of combining arthroscopic patellar denervation with microfracture in the treatment of patellofemoral arthritis under cold weather conditions.Methods:A total of 134 patients ...
关键词：arthroscopy patella DENERVATION MICROFRACTURE patellofemoral arthritis cold weather 
Correlation of PM_(2.5)pollution and daily mortality rate of cardiovascular and cerebrovascular diseases in Northeast China through PM_(2.5)sources analysis
《Frigid Zone Medicine》2024年第4期193-201,共9页Qianqi Hong Yang Zhao Jing Wang Hongyan Sun Lanxin Deng Jingjing Cao Cheng Wang 
supported by the National Natural Science Foundation of China(No.82273613);supported by the Research project of Health Commission of Heilongjiang Province(No.20231212010393).
Objective:This study aims to evaluate the relationship between PM_(2.5)concentration and daily mortality rate from cardiovascular and cerebrovascular diseases(CCVD)in cold regions of northern China,as well as to ident...
关键词：PM_(2.5) cardio-cerebrovascular diseases daily mortality time series PMF 
Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway
《Frigid Zone Medicine》2024年第4期202-211,共10页Nannan Tang Jiatong Li Zhuo Wang Jinlu Zuo Zifeng Zhang Di Huang Yannan Han Yuqing Chen Yilin Sun Xiang Li Ruxue Mu Qingxue Ma Jie Zhang Jiaying Wu He Wang Hongxia Zhao Xingli Dong Zhiguo Wang Yu Liu Dan Zhao Baofeng Yang 
supported by the National Natural Science Foundation of China(82330011,U21A20339);the CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003);the National Natural Science Foundation of China(No.82370302,31871175);Natural Science Foundation of Heilongjiang Province of China(No.YQ2019H003);College of Pharmacy,Harbin Medical University Excellent Young Talents Funding(No.2020-YQ-01).
Background:Small ubiquitin-like modifiers(SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer,diabetes,heart failure,and neurological diseases.How...
关键词：hypertension SUMO inhibitor ERK5 SUMOYLATION KLF2 
LCN2 aggravates diabetic cataracts by promoting ferroptosis in lens epithelial cells
《Frigid Zone Medicine》2024年第3期177-192,共16页Jiayue Zhang Liyao Sun Xiaohan Yu Chen Yang Qi An Chaoqun Wei Hongyan Ge 
approved by the Institutional Review Board(or Ethics Committee)of the First Affiliated Hospital of Harbin Medical University(IACUC:2022020 and date of approval:April 8,2022).
Background:Cataracts are the leading cause of reversible blindness worldwide.Diabetic cataract(DC),a prevalent complication of diabetes mellitus,is characterized by its high occurrence,rapid progression,and severe imp...
关键词：lipocalin-2 ferroptosis diabetic cataracts 
Seasonal variation in dietary intake and its association with obesity-related chronic diseases in northeast China
《Frigid Zone Medicine》2024年第3期129-136,共8页Cheng Wang Zican Li Dongwei Guan Hongxin Fu Rennan Feng 
supported by the National Natural Science Foundation of China(82273612,and 81573133).
Objective:The objective of this study was to assess seasonal changes in dietary and nutrient intake of residents(18-75 years old)in Northeast China during summer and winter,and to explore the associations between fatt...
关键词：obesity-related chronic diseases polyunsaturated fatty acid phytosterols 
Circulating CCRR serves as potential novel biomarker for predicting acute myocardial infarction
《Frigid Zone Medicine》2024年第3期137-151,共15页Lina Xuan Huishan Luo Shu Wang Guangze Wang Xingmei Yang Jun Chen Jianjun Guo Xiaomeng Duan Xiufang Li Hua Yang Shengjie Wang Hailong Zhang Qingqing Zhang Shulei Liu Yongtao She Kai Kang Lihua Sun 
supported by grants from the Natural Science Foundation of China(81970202,81903609);by Natural Science Foundation of Heilongjiang Province,China(LH2022H002);by the Outstanding Young Talent Research Fund of College of Pharmacy,Harbin Medical University(2019-JQ-02);2021(the second batch)Research Funds for affiliated research institutes in Heilongjiang Province(CZKYF2021-2-C013).
Objective:Cold regions exhibit a high prevalence of cardiovascular disease,particularly acute myocardial infarction(AMI),which is one of the leading causes of death associated with cardiovascular conditions.Cardiovasc...
关键词：acute myocardial infarction lncRNA cardiac conduction regulatory RNA EXOSOME 
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