《Fundamental Research》

作品数：606被引量：443H指数：7
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《Fundamental Research》
主办单位：National Natural Science Foundation of China
最新期次：2025年1期更多>>
发文主题：COMMENTARYQUANTUMOPTOMECHANICSMITPEROVSKITE更多>>
发文领域：理学医药卫生自动化与计算机技术一般工业技术更多>>
发文基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Adsorbate-driven dynamic active sites in stannosilicate zeolites
《Fundamental Research》2025年第1期174-182,共9页Xianfeng Yi Yao Xiao Changjiu Xia Fengqing Liu Yujia Liu Yu Hui Xin Yu Yucai Qin Wei Chen Zhiqiang Liu Lijuan Song Anmin Zheng 
supported by the National Key R&D Program of China(2021YFA1502600,and 2022YFE0116000);State Key Laboratory of Catalytic Materials and Reaction Engineering(RIPP,SINOPEC,33600000-20-ZC0607-0024);the National Natural Science Foundation of China(22032005,22125304,22002174,22241801,21991090,and 21991092).
Elucidating the nature of the active sites in heterogeneous catalysts is fundamental for understanding their reactivity and catalytic performances.Although stannosilicate zeolites have tremendous application potential...
关键词：Dynamic active sites Pseudo-Brønsted acid Stannosilicate zeolites Reaction conditions Solid-state NMR 
Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses
《Fundamental Research》2025年第1期183-191,共9页Liping Liu Jiayu Zhao Zichao Huang Yudi Xu Hongyu Chen Ruirui Qiao Wantong Song Zhaohui Tang Thomas P.Davis Xuesi Chen 
supported by grants from the National Natural Science Foundation of China(22222509,51973215,52025035,52103194,22105199);the Ministry of Science and Technology of China(2022YFE0110200);Bureau of International Cooperation Chinese Academy of Sciences(121522KYSB20200029);Jilin Province Science and Technology Development Plan(YDZJ202101ZYTS131,20220402037GH);Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers(20210504001GH);Changchun Science and Technology Development Plan(21ZY09);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2020232).
In recent years,the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design.However,current nanocarriers are restricted by diff...
关键词：Cancer immunotherapy Cancer vaccine NANOTECHNOLOGY Drug delivery BIOPOLYMER 
Current AAV-mediated gene therapy in sensorineural hearing loss
《Fundamental Research》2025年第1期192-202,共11页Jieyu Qi Xiaolong Fu Liyan Zhang Fangzhi Tan Nianci Li Qiuhan Sun Xiaojie Hu Zuhong He Ming Xia Renjie Chai 
supported by the National Key Research and Development Program of China(2020YFA0113600,2021YFA1101300,2020YFA0112503);Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303);the National Natural Science Foundation of China(82000984,82030029,81970882,81900937 and 82071013);Natural Science Foundation from Jiangsu Province(BE2019711);the China National Postdoctoral Program for Innovative Talents(BX20200082);the China Postdoctoral Science Foundation(2020M681468);the Science and Technology Department of Sichuan Province(2021YFS0371);Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2109);the Fundamental Research Funds for the Central Universities.
The number of patients with hearing loss is on the rise due to congenital abnormalities,degenerative changes in old age,and acquired injuries such as virus or ototoxic drug-induced diseases.Hearing loss is a refractor...
关键词：Hearing loss COCHLEA Gene therapy Adeno-associated virus Auditory repair 
Development of the inner ear and regeneration of hair cells after hearing impairment
《Fundamental Research》2025年第1期203-214,共12页Xin Bing Chengcheng Liu Xue Cao Chengzhilin Li Xiaochen Gao Fangyuan Zhu Xinhao Wu Na Guo Houyang Hu Ming Xia Miaoqing Zhao 
supported by grants from the National Natural Science Foundation of China(82071013,82071035,82371165);Natural Science Foundation of Shandong Province(ZR2022LZL001);Joint Fund of Shandong Province(ZR202ILSW028);Taishan Scholar Foundation of Shandong Province(tsqn201812134).
Hearing loss,as a sensory disorder,is the most common occurrence among humans,which has received increasing attention from society.It is mainly caused by the damage of inner ear hair cells(HCs)or the degeneration of s...
关键词：DEVELOPMENT Hearing impairment Hearing protection Inner ear hair cells REGENERATION 
Disease prediction by network information gain on a single sample basis
《Fundamental Research》2025年第1期215-227,共13页Jinling Yan Peiluan Li Ying Li Rong Gao Cheng Bi Luonan Chen 
supported by the National Natural Science Foundation of China(31930022,12131020,T2341007,T2350003);National Key R&D Program of China(2022YFA1004800);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040400);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004,2021B0909060002);Key-Area Research and Development Program of Guangdong Province(2021B0909060002);MajorKey Project of PCL(PCL2021A12),and JST Moonshot R&D(JPMJMS2021).
There are critical transition phenomena during the progression of many diseases.Such critical transitions are usually accompanied by catastrophic disease deterioration,and their prediction is of significant importance...
关键词：Tipping point Network information gain Dynamic network biomarker Disease prediction Network flow entropy Drug target 
The comprehensive assessment of epigenetics changes during skin development
《Fundamental Research》2025年第1期228-240,共13页Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng 
supported by the National Natural Science Foundation of China(82073421 and 82003326);the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(YX202007);the science and technology innovation Program of Hunan Province(2021RC3035);Natural Science Foundation of Hunan Province(2021JJ40924 and 2021JJ20089).
Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultrav...
关键词：EPIGENETICS Skin development AGING ULTRAVIOLET m^(6)A 
Out-of-phase relationship of Holocene moisture variations between the northeastern and southeastern Tibetan plateau and its societal impacts
《Fundamental Research》2025年第1期241-248,共8页Duo Wu Minmin Ma Yongxiu Lu Shilong Guo Tao Wang Xuyi Ma Guanghui Dong 
supported by the National Key R&D Program of China(2021YFC1523600);Major Project of National Social Science Foundation of China(21&ZD285).
It is widely accepted that Holocene climatic and environmental changes had major impacts on socioeconomic development and the evolution of civilization.The eastern margin of the Tibetan plateau(TP)has been an importan...
关键词：Climate change Spatiotemporal moisture variation Northeastern Tibetan plateau Yunnan Province Millet agriculture Late Neolithic and Bronze age 
Ozone exposure and cardiovascular disease:A narrative review of epidemiology evidence and underlying mechanisms
《Fundamental Research》2025年第1期249-263,共15页Qiaoyi Hua Xin Meng Jicheng Gong Xinghua Qiu Jing Shang Tao Xue Tong Zhu 
supported by the National Natural Science Foundation of China(42293324).
Ozone(O_(3))poses a significant global public health concern as it exerts adverse effects on human cardiovascular health.Nevertheless,there remains a lack of comprehensive understanding regarding the relationships bet...
关键词：Ozone exposure Cardiovascular disease Epidemiologic study Mechanism SUSCEPTIBILITY 
Shear softening of earth's inner core as indicated by its high poisson ratio and elastic anisotropy
《Fundamental Research》2025年第1期264-268,共5页Zhongqing Wu Wenzhong Wang 
Earth's inner core exhibits an unusually high Poisson ratio and noticeable elastic anisotropy.The mechanisms responsible for these features are crucial to understanding the nature of Earth's core.Although different me...
关键词：ELASTICITY Crystal structure Iron alloy Earth’s interior Composition 
Profiles and natural drivers of antibiotic resistome in multiple environmental media in penguin-colonized area in Antarctica
《Fundamental Research》2025年第1期269-281,共13页Yongpeng Zhang Bo Zhang Imtiaz Ahmed Hanshu Zhang Yiliang He 
supported by Polar Research Institute of China.The members of the 35th Antarctic expedition team were acknowledged for their support and help in sampling.
Profiles and driving mechanisms of antibiotic resistome in the polar region are important for exploring the natural evolution of antibiotic resistance genes(ARGs).Here,we evaluated the profiles of antibiotic resistome...
关键词：Antibiotic resistance genes Antibiotic-resistant bacteria RISK Mobile genetic element Source 
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