Authors of this research are in deep gratitude toward Professor Qin Wang from the Nanchang Research Institute,Sun Yat-sen University for her dedicated guidance and support to this work.This work was supported by the National Key R&D Program of China(2022YFC3500302);the Ministry of Science and Technology of China(No.2017YFC1703104);the Key Laboratory Project of Pharmaceutical Lipids in Guangdong Province(No.2020B1212070024);the Guangdong Province Key Areas R&D Program Project(No.2020B1111120002).
Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,whi...
Background:Hodgkin lymphoma refers to a malignancy of the lymphatic tissue.Extra-nodal Hodgkin lymphoma(ENHL)is a rare variant consisting of Hodgkin lymphoma occurring outside the lymphatic system.Studies investigatin...
Tianjin Health Technology Project(Grant no.2022QN106).
Background:Doublecortin(DCX),a microtubule-associated protein,is best known for its critical role in neuronal migration during neural development,where it stabilizes microtubules and guides neurons to their proper pos...
supported by the Science and Technology Project of Hebei Education Department(QN2018060);Hebei Natural Science Foundation(H2022209027);Tangshan Science and Technology Project(21130230C)and Tangshan Talent Funding Project(A202203021);the Central Government Guides Local Funds For Science a nd Technology Development(Free Exploration o f Basic Research):the synergistic effect of nuclear targeted PTX/CUR nanodelivery system combined photothermal/photodynamic on breast cancer(236Z2704G);Natural Science Foundation of Hebei Province(H2022209068).
Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes sign...
Guizhou Provincial Department of Science and Technology Natural Science Foundation(No Foundation-ZK[2022]);the Guizhou Provincial Health Commission Science and Technology Fund(No.GZWKJ2023-135);the Science Foundation of 925th Hospital(No.2023[3],No.2022[3/4]).
Background:The cyclin-dependent kinase inhibitor 2a(CDKN2A)gene,identified as the multiple tumor suppressor gene,functions as a regulatory gene implicated in cancer pathogenesis.Its significance lies in its pivotal in...
National Natural Science Foundation of China(No.81303095);Tianjin Science&Technology Program(No.12ZCDZSY15800).
Background:Lung cancer cachexia has received widespread attention as one of the most common complications in patients with advanced lung cancer.As a multifactorial syndrome,lung cancer cachexia is characterized by a p...
Objective:To explore the effect of Oxymatrine(OMT)on hepatocellular carcinoma cells and its possible action pathways.Methods:The core targets of Oxymatrine action in hepatocellular carcinoma were identified using netw...
In 2021,Wuxi Medical Innovation Team CXTD2021023,Jiangsu Province maternal and Child Health research key funding project F201915.
Objective:This study used comprehensive bioinformatics analysis and network pharmacology analysis to investigate the potentially relevant mechanisms of Sophora flavescens against cervical squamous cell carcinoma.Metho...
grants from the Tianjin Health Technology Project(Grant no.2022QN106).
Background:The ORAI1 gene,central to store-operated calcium entry(SOCE),is increasingly recognized for its pivotal role in cancer progression and patient prognosis across a broad spectrum of malignancies.Despite its c...
Gastric cancer is one of the most common malignant tumors,for patients with advanced gastric cancer,the traditional treatment is mainly chemotherapy or combined targeted therapy;however,these have not achieved ideal e...