Objective:To explore the effect of Oxymatrine(OMT)on hepatocellular carcinoma cells and its possible action pathways.Methods:The core targets of Oxymatrine action in hepatocellular carcinoma were identified using netw...
supported by funds provided by the National Natural Science Foundation of China(21974024 and 22274025)。
We developed a magnetic solid-phase extraction method using Fe_(3)O_(4)@polydopamine(Fe_(3)O_(4)@PDA)as adsorbents,coupled with liquid chromatography-tandem mass spectrometry(LC-MS/MS),for the enrichment and quantific...
Supported by National Key R&D Plan(2018YFC1708005);Sichuan Science and Technology Plan Project(2021YFS0043);Improvement of the Standard of Traditional Chinese Medicine(Ethnic Medicine)of Sichuan Medical Products Administration(510201202102305);Leading Talent Support Plan in 2021;Research Projects of Special Funds for Basic Scientific Research Business Expenses of Central Colleges and Universities(2021PTJS35).
[Objectives]To establish the quality standard of common clinical folk herb Sophora davidii var.chuansiensis.[Methods]The qualitative identification was performed by microscopic method and thin-layer chromatography(TLC...
In the present review,we updated current information on the chemistry,contents,and anticancer properties of matrine(MT),oxymatrine(OMT),and compound Kushen injection(CKI).The anticancer properties were focused on lung...
the National Natural Science Foundation of China(No.81873042,81872494 and 81803633).
Background:Cancer cachexia is a complex disease secondary to cancer,and no specific therapy for it has been found.The Chinese herb Kushen(Radix Sophorae flavescentis)is the dried root of Sophora flavescens Aiton,which...
Funded by the National Natural Science Foundation of China(No.51273156);the Health Commission of Hubei Province Scientific Research Project(No.WJ2019H275)。
This paper provides a new treatment for gastric cancer with a new OMT delivery system.We synthesized MPEG-PCL,an amphiphilic polymer,to construct a nanoparticle encapsulated OMT by pH gradient method,and then examined...
In the original version of Fig.2,the marker line between column 2 and column 6 is redundant(Fig.2A),and MVC label and MVCIOMT label were accidentally swapped(Fig.2B).The correct Fig.2 is provided below.
funded by the Natural Sciences Foundation of China (31760041) to YS;the West China first-class Disciplines Basic Medical Sciences at Ningxia Medical University (No. NXYLXK2017B07);Innovative Training Program for College Students (201510752010) to NL
Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is...
Supported by Natural Science Foundation Project of Guangxi(2014GXNSFAA118143);Excellent Talents Funding Program of Colleges and Universities in Guangxi(RC20077029);Key Scientific Research Program for Medical Care and Health of Guangxi Health Department(200887)
[Objectives] To observe the effects of oxymatrine on the proliferation,invasion and migration of hepatocellular carcinoma cells,and to explore its possible molecular mechanism.[Methods]The hepatocellular carcinoma cel...
Supported by the Jiangsu Bureau of Traditional Chinese Medicine,No.YB2015177
To evaluate the effect of oxymatrine (OMT) on hepatocyte apoptosis in rats with lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute liver failure (ALF).METHODSLPS/D-GalN was used to establish a model of AL...