PAZOPANIB

作品数：22被引量：21H指数：2
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相关作者：祖强符伟军洪宝发肖越勇具海月更多>>
相关机构：中国人民解放军总医院中国药科大学广州医科大学北京大学更多>>
相关期刊：《Journal of Biomedical Science and Engineering》《World Journal of Clinical Oncology》《药学进展》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway被引量：2
《Acta Pharmacologica Sinica》2023年第6期1135-1148,共14页Hong-yang Sun Jin Wu Rui Wang Shun Zhang Hao Xu Еlena Kaznacheyeva Xiao-jun Lu Hai-gang Ren Guang-hui Wang 
supported by the National Natural Science Foundation of China(No.32271039,32070970,31970966);the Joint Program RFBR-BRICS(No.17-54-80006);a Project Funded by the Priority Academic Program Development of JiangsuHigherEducationInstitutions.
Parkinson’s disease(PD)is a progressive neurodegenerative disease characterized by the loss of dopaminergic(DA)neurons and the accumulation of Lewy bodies(LB)in the substantia nigra(SN).Evidence shows that microglia-...
关键词：Parkinson’s disease NEUROINFLAMMATION PAZOPANIB MEK4-JNK-AP-1 pathway drug repositioning 
First-line pazopanib in patients with advanced non-clear cell renal carcinoma:An Italian case series
《World Journal of Clinical Oncology》2021年第11期1037-1046,共10页Sebastiano Buti Melissa Bersanelli Francesco Massari Ugo De Giorgi Orazio Caffo Gaetano Aurilio Umberto Basso Giacomo Carteni Claudia Caserta Luca Galli Francesco Boccardo Giuseppe Procopio Gaetano Facchini Giuseppe Fornarini Alfredo Berruti Elena Fea Emanuele Naglieri Fausto Petrelli Roberto Iacovelli Camillo Porta Alessandra Mosca 
BACKGROUND Non-clear cell(ncc)metastatic renal-cell carcinoma(RCC)has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell counterpart.New systemic combinatio...
关键词：PAZOPANIB Non-clear cell Kidney cancer Renal-cell carcinoma Variant histology Tyrosine kinase inhibitors 
pazopanib血药浓度个体差异与细胞色素P4503A4基因多态性的关系初探被引量：2
《中国临床药理学与治疗学》2020年第12期1376-1380,共5页吴茂锋 刘畅 戴慧晖 麦长凤 黄丹丽 缪经纬 刘丽忠 方翼 
清远市科技计划基金资助项目(DZXQY002);清远市人民医院医学科研基金资助项目(20190208)。
目的:分析健康受试者口服pazopanib片后体内药代动力学(PK)规律,初步探讨pazopanib片PK个体差异的遗传学机制。方法:14例健康男性受试者分别在给药当天单次口服pazopanib片(200 mg)后,采集基线至96 h血液样本,用LC-MS/MS法测定服药后各...
关键词：PAZOPANIB 细胞色素P4503A4 基因多态性 
Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?
《Neural Regeneration Research》2020年第6期1166-1168,共3页Jonathan Wong So Bérenger Largeau Frédérique Beau-Salinas Stephan Ehrmann Christophe Magni Jérome Meunier 
Introduction:Pazopanib is an oral protein kinase inhibitor(PKI)that targets vascular endothelial growth factor(VEGF)receptors,fibroblastic growth factor receptors,platelet-derived growth factor receptors,and stem cell...
关键词：al. SIADH antidiuretic 
Posterior Reversible Encephalopathy Syndrome Induced by Pazopanib in a Patient with Soft-Tissue Sarcoma: A Case Report
《Case Reports in Clinical Medicine》2019年第5期127-133,共7页Chien-Ting Wu Chieh-Tsung Yen Hsiu-Lan Cheng Chi-Hui Lee 
Posterior reversible encephalopathy syndrome (PRES), a rare disease is characterized by multiple neurological complications. It has been reported to be associated with the use of angiogenesis inhibitors such as sorafe...
关键词：POSTERIOR REVERSIBLE ENCEPHALOPATHY Syndrome PAZOPANIB HEPATOCELLULAR Carcinoma Vascular ENDOTHELIAL Growth Factor Magnetic Resonance Imaging 
Pazopanib in advanced soft tissue sarcomas被引量：3
《Signal Transduction and Targeted Therapy》2019年第1期538-547,共10页Alex T.J.Lee Robin L.Jones Paul H.Huang 
Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascula...
关键词：SARCOMA CLINICAL APPROVAL 
The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery被引量：2
《International Journal of Ophthalmology(English edition)》2018年第12期1909-1915,共7页Sabiha Gungor Kobat Fatma Ulku Celiker Adile Ferda Dagli Kader Kasar 
AIM: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy. METHODS: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart fr...
关键词：TRABECULECTOMY wound healing CORTICOSTEROID BEVACIZUMAB PAZOPANIB 
Case Report: Pazopanib Treatment Response in a Patient with Metastatic Pleomorphic Dermal Sarcoma (Atypical Fibroxanthoma) with Circulating Tumor Cell-Derived Colonies as a Predictive Marker
《Journal of Cancer Therapy》2016年第11期785-793,共9页Wolfram E. Samlowski Joseph Wojcik Suzanne Samlowski Douglas Fife Todd Murry 
Atypical fibroxanthomas (AFX) are rare skin tumors. These generally are superficial tumors, usually <3 cm red, fleshy, ulcerated skin lesions, that characteristically occur on sun-damaged skin, sometimes in immunocomp...
关键词：Atypical Fibroxanthoma Pleomorphic Dermal Sarcoma Vascular Endothelial Growth Factor Receptor Targeted Therapy Circulating Tumor Cells Circulating Tumor Cell-Derived Cultures 
Pazopanib Induced Hand-Foot Syndrome in a Patient Previously Treated with Sunitinib: A Possible Cumulative Skin Toxicity?
《Pharmacology & Pharmacy》2016年第8期354-357,共4页Emanuele Cozzani Sanja Javor Stefano Ottoboni Aurora Parodi 
Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is a skin toxicity that could be observed during target therapies such as with tyrosine-kinase inhibitors (TKI). It usually develops within th...
关键词：Hand-Foot Syndrome PAZOPANIB SUNITINIB Tyrosine-Kinase Inhibitors Cumulative Toxicity 1. 
Molecular Markers of Kidney Cancer Progression, Association with Efficiency of Pazopanib Therapy
《Journal of Biomedical Science and Engineering》2015年第11期756-766,共11页Liudmila V. Spirina Evgeny A. Usynin Irina V. Kondakova Zahar A. Yurmazov Elena M. Slonimskaya 
Purpose: The aim of the study is to reveal associations between NF-κB, HIF-1alpha, VEGF expres-sions, proteasome and calpain activities with tumor progression in patients with kidney cancers and to find molecular par...
关键词：Kidney Cancer NF-κB HIF-1 VEGF VEGFR2 m-TOR PROTEASOME CALPAIN PAZOPANIB 
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