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Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach: 《Acta Pharmaceutica Sinica B》2024年第10期4443-4460,共18页Jianguo Song Ruili Huang Jialiao Cai Zhenlong Wu Lijun Hu Wanyang Sun Xiaojun Huang Rongrong He Wei Tang Wencai Ye Ying Wang; supported by the National Key R&D Program of China(No.2023YFC3503902,China);the National Natural Science Foundation of China(Nos.82293681(82293680);82321004,82204234,and 82273822,China);the Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515120015 and 2021A1515111021,China);the Guangdong Major Project of Basic and Applied Basic Research(No.2023B0303000026,China);the Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine(No.2023LSYS002,China);the Guangzhou Key Laboratory of Traditional Chinese Medicine&Disease Susceptibility(No.2024A03J090,China);the Science and Technology Projects in Guangzhou(No.202102070001,China);supported by the high-performance computing platform of Jinan University.; The building blocks-based molecular network(BBMN)strategy was applied to the phytochemical investigation of Cleistocalyx operculatus,leading to the targeted isolation of eighteen novel cinnamoylphloroglucinol-terpene ...; 关键词：Cleistocalyx operculatus Cinnamoylphloroglucinolterpene adduct Targeted isolation Molecular networking Structure elucidation Cleistoperone A Respiratory syncytial virus Antiviral activity

Discovery of Eucalyptin C,derived from the fruits of Eucalyptus globulus Labill.,as a novel selective PI3Kγinhibitor for immunosuppressive treatment被引量：1: 《Chinese Journal of Natural Medicines》2021年第11期844-855,共12页HU Xiao-Long SHEN Wei WANG Rong LONG Huan WANG Quan FENG Jia-Hao PHAM Thi-Anh XIONG Fei YE Wen-Cai WANG Hao; This work was supported by China Postdoctoral Science Foundation(Nos.2019M662006 and 2019TQ0357);the National Natural Science Foundation of China(Nos.81973206,81803392 and 81573309);the Major National Science and Technology Projects of the Chinese Thirteen Five-Year Plan(No.2017ZX09309024);the Funding of Double First-rate Discipline Innovation Team(Nos.CPU2018PZQ17,CPU2018PZQ18,and CPU2018GF05);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036);the Research and Innovation Project for College Graduates of Jiangsu Province 2017(No.KYCX170694);the National College Student Innovation Project for the R&D of Novel Drugs(No.201710316100);Jiangsu Province Graduate Student Training Innovation Project(No.KYLX16_1208).; The fruits of Eucalyptus globulus Labill.are known to have a plenty of medicinal properties,such as anti-tumor,anti-inflammatory,and immunosuppressive activity.Our previous study found that the phloroglucinol-sesquite...; 关键词：Phosphoinositide 3-kinase-γ(PI3Kγ) Eucalyptin C Immunosuppressive effects Activated spleen cells Phloroglucinol-sesquiterpene adducts

Herpotrichones A and B,two intermolecular [4+2] adducts with anti-neuroinflammatory activity from a Herpotrichia species被引量：1: 《Science Foundation in China》2020年第2期54-54,共1页; With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof.Gao JinMing (高锦明)at Shaanxi Key Laboratory of Chemical Biology of Natural Produ...; 关键词：PHARMACY INFLAMMATORY compounds.

Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis,treatment, and outcomes被引量：36: 《World Journal of Gastroenterology》2019年第28期3753-3763,共11页Xiao-Qian Yang Jin Ye Xin Li Qian Li Yu-Hu Song; Supported by National Natural Science Foundation of China,No.81570555 and No.81770582; Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS be...; 关键词：HEPATIC sinusoidal obstruction syndrome PYRROLIZIDINE alkaloids HEPATIC sinusoidal endothelial cells Pyrrole-protein ADDUCTS Diagnostic criteria Symptomatic TREATMENT ANTICOAGULANT therapy

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology被引量：6: 《Journal of Clinical & Translational Research》2017年第1期13-25,共13页Anup Ramachandran Hartmut Jaeschke; Acetaminophen(APAP)overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation.Studies in the mo...; 关键词：ACETAMINOPHEN HEPATOTOXICITY protein ADDUCTS mitochondria oxidative stress NITRIC oxide DNA fragmentation regulated NECROSIS mitochondrial dynamics biomarkers

Determination of ginsenoside compound K in human plasma by liquid chromatography–tandem mass spectrometry of lithium adducts被引量：3: 《Acta Pharmaceutica Sinica B》2015年第5期461-466,共6页Yunhui Chen Youming Lu Yong Yang Xiaoyan Chen Liang Zhu Dafang Zhong; Ginsenoside compound K(GCK), the main metabolite of protopanaxadiol constituents of Panax ginseng, easily produces alkali metal adduct ions during mass spectrometry particularly with lithium. Accordingly, we have deve...; 关键词：LC MS/MS Ginsenoside compound K Lithium adduct ion PHARMACOKINETICS

Pre-Chelates, Post-Adducts and Implexes: A perspective proposal for the future of medicinal chemistry: 《Advances in Biological Chemistry》2013年第6期553-555,共3页Mario Gosalvez; The title of this little assay coins three new words: Pre-Chelates, Post-Adducts and Implexes. These, very daring new excursions into the scientific English language, come from the developments of Quelamycin and Sodiu...; 关键词：New CHELATES and ADDUCTS Embracing Metals Future of MEDICINAL THERAPEUTICS Quelamycin Thioproli

<i>Gsta</i>4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity被引量：2: 《Open Journal of Apoptosis》2013年第1期1-11,共11页Kevin E. McElhanon Chhanda Bose Rajendra Sharma Liping Wu Yogesh C. Awasthi Sharda P. Singh; The alpha class glutathione s-transferase (GST) isozyme GSTA4-4 (EC2.5.1.18) exhibits high catalytic efficiency towards 4-hydroxynon-2-enal (4-HNE), a major end product of oxidative stress induced lipid peroxidation. ...; 关键词：Glutathione TRANSFERASE Protein ADDUCTS Lipid Peroxidation OXIDANTS Stress Kinases

Immunological response in alcoholic liver disease被引量：9: 《World Journal of Gastroenterology》2007年第37期4938-4946,共9页Michael J Duryee Lynell W Klassen Geoffrey M Thiele; The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune compone...; 关键词：Alcoholic liver disease Liver endothelial cells Aldehyde adducts Oxidative stress Immune system CYTOKINES METABOLISM

How can the Cross-Link Adducts Formed by Novel Trans Platinum Drug be Influenced by Hydrogen Bond: 《Chinese Journal of Chemistry》2006年第11期1514-1522,共9页常贯儒周立新陈动; Project supported by the Science Foundation of Jinan University （No. 639）.; A systematic quantum chemical characterization of intrinsic structure, energies and spectral properties of all the studied cross-link adducts formed by the novel trans platinum with thiazole ligand has been carried ou...; 关键词：hydrogen bond VCD spectrum ENANTIOMER cross-link （CL） DFT

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