The production of unsymmetrical ureas,which are widely used in the pharmaceutical field[1],still relies heavily on the multi-steps reaction of two different amines with extremely toxic phosgene as the carbonyl source,...
Substituted ureas hold considerable significance in both natural and synthetic chemicals.Pd-based homogenous catalyst has been used for the urea synthesis,however the aggregation of Pd(0)species leads to the deactivat...
the National Natural Science Foundation of Chinaa(Nos.22271113,92256301,21822103,91956201,21820102003 and 21602052);the Natural Science Foundation of Hubei Province(No.2022CFB413);the fund from Central China Normal University for support of this research.
Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen bonds.Therefore,it is of great scientific significance to develop efficient and green methods fo...
National Natural Science Foundation of China(Grant No.21877005).
In the present study,we described a continuous-flow,one-pot synthesis of asymmetrical ureas using nucleophilic addition reaction of amines to isocyanates derived from acids’Curtius rearrangement.The advantages of thi...
supported by the National Natural Science Foundation of China(No.21262012);the Natural Science Foundation of Hubei Province(No.2016CFB400)
N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a~4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single ...
financially supported by the Capacity Building Project of Some Local Colleges and Universities in Shanghai (No. 17030501200);the National Natural Science Foundation of China (No. 81501595);Youth Foundation of Zhongshan Hospital (No. 2015ZSQN09);Talent Training Program Foundation for the Excellent Youth Supported by Zhongshan Hospital (No. 2017ZSYQ24);Innovation Fund of Zhongshan Hospital (No. 2017ZSCX05)
Electrospun nanofibrous mats represent a new generation of medical textiles with promising applications in heart valve tissue reconstruction. It is important for biomaterials to mimic the biological and mechanical mic...
Strigolactones,a class of plant hormones with multiple functions,mediate plant-plant and plantmicroorganism communications in the rhizosphere.In this study,we developed potent strigolactone antagonists,which covalentl...
supported by the National Natural Science Foundation of China(Nos.21572042 and 21773052);the Program for Innovative Research Team in Chinese University(No.IRT 1231);the Natural Science Foundation of Zhejing Province(Nos.LZ16B020002 and LQ17B040002);the Public Welfare Technology and Application Program of Zhejiang Province(No.2015C31141)
Three tetraurea-appended porphyrin derivatives were synthesized and applied as anion receptors to complex with various anions, including F^-, Cl^-, Br^-, I^-, NO3^-, HSO4^-, and AcO^-. The binding stoichiometries were...
Financial support from National Basic Research Program of China (973 Program) (No. 2015CB856600), the National Natural Science Foundation of China (Nos. 21325206, 21632001), National Young Top-notch Talent Support Program, CAS Interdisciplinary Innovation Team, and Peking University Health Science Center (Nos. BMU20150505, BMU20160541) is greatly ap- preciated. We thank Bencong Zhu and Ao Sun in this group for reproducing the results of 2a and 2k.
An efficient KI catalyzed nitrogenation of aldehydes and alcohols for the direct synthesis of carbamoyl azides and ureas via a radical process has been developed. The simple operating procedures, the readily available...
A facile, efficient and cost-effective approach to 1,3-dibenzylurea was reported. With cheap and recycla- ble nonmetal selenium as catalyst, carbon monoxide instead of phosgene derivatives as earbonylation agent and o...