PHOSPHORYLCHOLINE

作品数：20被引量：40H指数：4
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相关领域：医药卫生理学更多>>
相关作者：陆春燕周宁琳更多>>
相关机构：江苏省生物医药功能材料工程研究中心南京师范大学南京大学更多>>
相关期刊：《Chinese Journal of Polymer Science》《Transactions of Tianjin University》《International Journal of Oral Science》《Frontiers of Chemical Science and Engineering》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金江苏省自然科学基金更多>>
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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release被引量：1
《Friction》2023年第7期1194-1211,共18页Xiaowei MAO Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG 
financially supported by the National Natural Science Foundation of China(52022043 and 21868011);Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(20191080593);Precision Medicine Foundation,Tsinghua University,China(10001020107);the National Key R&D Program of China(2017YFC1103800);Research Fund of State Key Laboratory of Tribology,Tsinghua University,China(SKLT2022C18).
Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhance...
关键词：surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication OSTEOARTHRITIS 
Functionalization of PEG-PM PC-based polymers for potential theranostic applications
《Frontiers of Materials Science》2021年第2期280-290,共11页Ning CHEN Sidi LI Xueping LI Lixia LONG Xubo YUAN Xin HOU Jin ZHAO 
supported by the National Natural Science Foundation of China(Grant Nos.51673146,51673144 and 51773151).
The synergistic effect of polyethylene glycol(PEG)and poly(2-methacry-loyloxyethyl phosphorytcholine)(PMPC)can effectively reduce the protein absorption,which is beneficial to theranostics.However,PEG-PMPC-based polym...
关键词：polyethylene glycol poly(2-methacryloyloxyethyl phosphorylcholine) atom transfer radical polymerization self-assembly monomolecular micelles 
Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery被引量：2
《Acta Pharmaceutica Sinica B》2021年第2期560-571,共12页Shaojun Peng Boshu Ouyang Yongjie Xin Wei Zhao Shun Shen Meixiao Zhan Ligong Lu 
financially supported by the National Key Research and Development Program of China(No.2017YFA0205200);the National Natural Science Foundation of China(Grant No.81903165 and 81901857);the Chinese Postdoctoral Foundation(Grant No.2019M663361,China)
Tumor microenvironment has been widely utilized for advanced drug delivery in recent years,among which hypoxia-responsive drug delivery systems have become the research hotspot.Although hypoxia-responsive micelles or ...
关键词：Hypoxia-degradable Zwitterionic nanogel Long blood circulation Drug release Drug delivery 
AB085.E-beam sterilization of recombinant human collagen-phosphorylcholine corneal implants for transplantation
《Annals of Eye Science》2018年第1期491-491,共1页Fiona Simpson Joel Edin Mohammed Mirazol Islam Oleksiy Buznyk Monika Ljunggren Kozak Aneta Liszka Kim Merrett Håkan Per Fagerholm Gustafsson May Griffith 
Background:The sterilization of corneal implants composed of carbodiimide crosslinked recombinant human collagen type III(RHCIII)and phosphorylcholine polymers(RHCIII-MPC)is constrained by the biochemical properties o...
关键词：CORNEA collagen tissue scaffolds implant regenerative medicine 
Resisting Protein but Promoting Cell Adhesion by Choline Phosphate:A Comparative Study with Phosphorylcholine
《Journal of Bioresources and Bioproducts》2018年第1期3-8,共6页Fuhui Huang Chunmei Ding Jianshu Li 
support by the National Natural Science Foundation of China(51503126,21534008,51573110);Scientific Research Foundation for Young Teachers of Sichuan University(2015SCU11005);Miaozi Project in Science and Technology Innovation Program of Sichuan Province(2016087).
Zwitterionic materials are now widely used to fabricate various functionalized surfaces for biomedical applications due to their excellent non-fouling properties.However,a newly-discovered zwitterionic material,cholin...
关键词：ZWITTERIONIC Choline phosphate PHOSPHORYLCHOLINE ATRP Non-fouling properties 
Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer被引量：4
《Nano Research》2016年第8期2424-2432,共9页Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang 
This work is supported by the National Natural Science Foundation of China （NSFC, Nos. 51343007, 81271612 and 81401439）, Shanghai Pujiang Program （No. 13PJD022）, and Shanghai Health Bureau Fund （No. 20124016）.
Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a tw...
关键词：phosphorylcholine-basedpolymer nano-encapsulation function protein delivery protein therapy long-circulation 
Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins被引量：13
《Nano Research》2016年第4期1022-1031,共10页Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu 
This work is supported by the National Natural Science Foundation of China （NSFC, Nos. 91127045, 51390483, 51473319, 51303025, 81401439 and 51343007）, YG2012MS38 and China Postdoctoral Science Foundation （No. 2014M551399）.
Protein therap34 wherein therapeutic proteins are delivered to treat disorders, is considered the safest and most direct approach for treating diseases. However, its applications are highly limited by the paucity of e...
关键词：protein nanocapsule protein delivery protein therapy long-circulation stealth therapeutic 
A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine被引量：8
《International Journal of Oral Science》2015年第2期103-109,共7页Ning Zhang Chen Chen Mary AS Melo Yu-Xing Bai Lei Cheng Hockin HK Xu 
supported by the School of Stomatology at the Capital Medical University in China(Ning Zhang);NIHR01 DE 17974(Hockin HK Xu) ;a Seed Grant(Hockin HK Xu) from the University of Maryland School of Dentistry
Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure.To date,there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachmen...
关键词：biofilm dental attachment caries antibacterial phospholipid ammonium deviation applicable sorption 
Modification of biomaterials surface by mimetic cell membrane to improve biocompatibility被引量：3
《Frontiers of Materials Science》2014年第4期325-331,共7页Lei ZHOU Guo-Xin TAN Cheng-Yun NING 
The authors gratefully acknowledge the financial support of the National Basic Research Program of China （Grant No. 2012CB619100） and the National Natural Science Foundation of China （Grant Nos. 51372087, 51232002, and 51072055）.
Modification of biomaterials surface by mimetic cell membrane for improving biocompatibility, to imitate the excellent biological and physiological proper- ties of the natural cell membrane, is an important research a...
关键词：mimetic cell membrane phosphorylcholine （PC） BIOCOMPATIBILITY SURFACEMODIFICATION biomaterial 
Improved biocompatibility of phosphorylcholine end-capped poly(butylene succinate)
《Science China Chemistry》2013年第2期174-180,共7页ZHANG ShiPing WANG LiLi YANG Shan GONG YongKuan 
financially supported by the National Natural Science Foundation of China (21004048, 20974087);the Natural Science Foundation of Shaanxi Educational Committe (2010JK886);the Science Foundation of Northwest University (NF0912)
In this work, the biocompatibility of a biomimetic, fully biodegradable ionomer phosphorylcholine (PC)-functionalized poly(butylene succinate) (PBS-PC) was investigated by means of hemolysis, platelet adhesion, protei...
关键词：PHOSPHORYLCHOLINE poly（butylene succinate） BIOCOMPATIBILITY platelet adhesion HEMOLYSIS CYTOTOXICITY 
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