ATAXIA-TELANGIECTASIA

作品数：10被引量：8H指数：2
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相关机构：台湾大学更多>>
相关期刊：《Genes & Diseases》《Computational Molecular Bioscience》《Neural Regeneration Research》《Cancer Biology & Medicine》更多>>
相关基金：国家自然科学基金更多>>
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ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells
《Biomedical and Environmental Sciences》2024年第8期834-849,共16页Jing Xie Jiaxin Tang Yuan Li Xue Kong Wei Wang Haibo Wu 
supported by the Natural Science Foundation of Anhui Province(2208085MH250,2308085MH272);National Key Research and Development Program of China(2021YFF1201000);Natural Science Research Project of the Anhui Educational Committee(2023AH040404,2023AH053402);Anhui Provincial Health and Medical Research Project(AHWJ2023A10143);Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(2023IHM01043)。
Objective Vasculogenic mimicry(VM)is a novel vasculogenic process integral to glioma stem cells(GSCs)in glioblastoma(GBM).However,the relationship between VM and ataxia-telangiectasia mutated(ATM)serine/threonine kina...
关键词：GLIOBLASTOMA Vasculogenic mimicry Ataxia-telangiectasia mutated(ATM) Glioma stem-like cell 
Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians
《Genes & Diseases》2024年第3期106-108,共3页Long Feng Hongqi Huo Qun Li Tao Yang Yali Zhao Pei Zhang Ping Ping Shihui Fu 
supported by grants from the Military Medical Science and Technology Youth Incubation Program(No.20QNPY110,19QNP060);the National Natural Science Foundation of China(No.81900357,81941021,81903392,81901252,82001476,81802804,81801251);the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital(No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China(No.821QN389,821MS112,822MS198,820MS126,820QN383);the National Key R&D Program of China(No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China(No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China(No.YSPTZX202216);the Medical Big Data R&D Project of Chinese People's Liberation Army General Hospital(No.MBD2018030);the China Postdoctoral Science Foundation Funded Project(No.2019M650359,2020M682816,2021T140298);the Heatstroke Treatment and Research Center of Chinese People's Liberation Army,the Simulation Training for Treatment of Heat Stroke;the Major Science and Technology Programme of Hainan Province,China(No.ZDKJ2019012).
Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with tho...
关键词：ATM development cognitive 
Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality被引量：2
《Neural Regeneration Research》2023年第3期497-502,共6页Yulia Mitiagin Ari Barzilai 
Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangi...
关键词：ataxia telangiectasia ATM CEREBELLUM DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks 
Antibody-Like Phosphorylation Sites. Theme for Studies of Cancer, Aging and Evolution
《Computational Molecular Bioscience》2022年第1期58-83,共26页Jaroslav Kubrycht Karel Sigler 
Sequence similarities were found between protein and DNA sequences encoding certain part of conserved variable immunoglobulin domains (i.e. conserved IgV) and phosphorylation sites. Hypermutation motifs were then indi...
关键词：Ataxia-Telangiectasia-Mutated Kinase (ATM) CARCINOGENESIS Complementarity Determining Region 1 (CDR1 Hypervariable Region 1) Conserved Domain(s) Deep Evolution EVOLUTION HYPERMUTATION Kinase(s) Phosphorylation Site(s) Plant Immunity Variable Immunoglobulin Domain(s) (IgV) 
Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80
《Cancer Biology & Medicine》2020年第3期640-651,共12页Mingming Xiao Xuesong Li Yang Su Zhuang Liu Yamei Han Shuai Wang Qinghua Zeng Hong Liu Jianwei Hao Bo Xu 
This work was supported by the National Natural Science Foundation of China(Grant Nos.81672743 and 81974464);Beijing Tianjin Hebei Basic Research Cooperation Project(Grant No.19JCZDJC64500(Z));Shenzhen Basic Research Project(Grant No.JCYJ20160331114230843);Tianjin Municipal Health Commission(Grant Nos.2015KR11 and 2013KG134);Tianjin Municipal Science and Technology Bureau(Grant No.18JCYBJC27800);US NIH grant RO 1 CAI33093,the Alabama Innovation Fund of the United States;the Tianjin Medical University Cancer Institute and Hospital Innovation Fund(Grant No.1803)。
Objective:Mitotic arrest-deficient protein 1(MAD1)is a kinetochore protein essential for the mitotic spindle checkpoint.Proteomic studies have indicated that MAD1 is a component of the DNA damage response(DDR)pathway....
关键词：DNA damage response ataxia-telangiectasia mutated kinase(ATM) mitotic arrest-deficient protein 1(MAD1) KU80 protein DNA-PKCS 
Ataxia-telangiectasia complicated with Hodgkin's lymphoma:A case report
《World Journal of Clinical Cases》2020年第11期2387-2391,共5页Xiao-Ling Li Yi-Lin Wang 
BACKGROUND Ataxia-telangiectasia(AT)is a rare,autosomal recessive,multisystem disorder.Because most clinicians have low awareness of the disease,only scarce reports of AT exist in the literature,especially of cases wi...
关键词：ATAXIA-TELANGIECTASIA Hodgkin's lymphoma CHILD Case report ATM gene 
Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1被引量：1
《Journal of Clinical & Translational Research》2016年第1期27-38,共12页Evi Arfianti Claire Z Larter Seungsoo Lee Vanessa Barn Geoffrey Haigh Matthew M.Yeh George NIoannou Narci C.Teoh Geoffrey C.Farrell 
Background:There are strong links between obesity,diabetes and hepatocellular carcinoma(HCC),but molecular mechanisms remain unclear.Aim:We tested the proposed involvement of NF-κB,IL-6/STAT3 and Akt/mTORC1 before on...
关键词：ATAXIA-TELANGIECTASIA mutated GLUTATHIONE-S-TRANSFERASE pi RAPAMYCIN INTERLEUKIN-6 signal transducer and activator of transcription3 
Functional role of ATM in the cellular response to DNA damage
《Frontiers of Chemical Science and Engineering》2011年第2期179-187,共9页Ming LIU Wenxiang HU 
support of the National Natural Science Foundation of China(Grant No.20872095)was gratefully acknowledged.
Ataxia-telangiectasia mutated(ATM)plays a key role in regulating the cellular response to ionizing radiation.The tumor-suppressor gene ATM,mutations in which cause the human genetic disease ataxia telangiecta-sia,enco...
关键词：ataxia-telangiectasia mutated(ATM) cell cycle checkpoint DNA damage signalling transduction 
A Correlative Study of Ataxia-telangiectasia Mutated Protein Expression of Four Tumor Cell Lines and Their Radiosensitivity after Different LET Radiation
《近代物理研究所和兰州重离子加速器实验室年报：英文版》2008年第1期76-76,共1页Wei Wei Li Wenjian Wang Zhuanzi Dang Bingrong Hao Jifang 
关键词：毛细血管扩张 放射敏感性 电离辐射 细胞系 失调 肿瘤 突变 蛋白 
Multiple Defects of Cell Cycle Checkpoints in U937-ASPI3K, an U937 Cell Mutant Stably Expressing Anti-Sense ATM Gene cDNA被引量：5
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2000年第4期273-276,共4页周剑锋 刘文励 孙岚 孙汉英 汤屹 
This project was supported by the National Natural ScienceFoundation of China (No. 39800149)
(Ataxia-telangiectasia mutated gene (ATM) functions in control of cell cycle checkpoints in responding to DNA damage and protects cells from undergoing apoptosis. Knock-out within tumor cells of endogenous ATM will ...
关键词：ataxia-telangiectasia mutated ATM cell cycle apoptosis cell cycle checkpoints 
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