ANTIMYCOBACTERIAL

作品数：13被引量：18H指数：3
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相关领域：医药卫生化学工程更多>>
相关期刊：《Infectious Microbes & Diseases》《Asian Pacific Journal of Tropical Medicine》《Cellular & Molecular Immunology》《Advances in Biological Chemistry》更多>>
相关基金：国家自然科学基金重庆市自然科学基金更多>>
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Macrophages exploit the mannose receptor and JAK-STAT1- MHC-Ⅱ pathway to drive antigen presentation and the antimycobacterial immune response after BCG vaccination被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1130-1144,共15页Ying Zhang Dandan Xu Qi Nie Jing Wang Dan Fang Yan Xie Huang Xiong Qin Pan Xiao-Lian Zhang 
supported by the grants from the National Key R&D Program of China(Nos.2022YFA1303500 and 2018YFA0507603);the National Natural Science Foundation of China(Nos.82230078,22077097,91740120,21721005,82272978 and 21572173);the Fundamental Research Funds for the Central Universities.
Tuberculosis(TB),caused by Mycobacterium tuberculosis(M.tb),remains one of the leading causes of fatal infectious diseases worldwide.The only licensed vaccine,Mycobacterium bovis Bacillus Calmette-Guérin(BCG),has var...
关键词：BCG vaccine mannose receptor MACROPHAGE antigen presentation 
Drug Repurposing for the Treatment of Mycobacterium abscessus Infections
《Infectious Microbes & Diseases》2023年第3期101-110,共10页Emily J.Baker Antonia Molloy Jonathan A.G.Cox 
funded by the Engineering and Physical Sciences Research Council(EPSRC)and Science Foundation Ireland(SFI)Centre for Doctoral Training in Engineered Tissues for Discovery,Industry and Medicine(EP/S02347X/1);EJB is supported by a PhD Studentship funded by LifETIME CDT(EPSRC and SFI);AM is supported by a PhD Studentship jointly funded by LifETIME CDT(EPSRC and SFI)and Sphere Fluidics.
With the ever-increasing burden of antimicrobial resistance,the demand to introduce countermeasures becomes increasingly critical.The urgency of this need is intensified by the void in antibiotic discovery,with the id...
关键词：drug repurposing Mycobacterium abscessus antimycobacterial drug discovery antimicrobials 
A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives
《Infectious Microbes & Diseases》2022年第4期139-148,共10页Christian K.Ezeh Chibuzor N.Eze Uju M.E.Dibua Stephen C.Emencheta 
Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health proble...
关键词：antimycobacterial activity silver nanoparticles CYTOTOXICITY biological synthesis TUBERCULOSIS MYCOBACTERIAL 
Lnc-EST12,which is negatively regulated by mycobacterial EST12,suppresses antimycobacterial innate immunity through its interaction with FUBP3被引量：4
《Cellular & Molecular Immunology》2022年第8期883-897,共15页Qili Yao Yan Xie Dandan Xu Zilu Qu Jian Wu Yuanyuan Zhou Yuying Wei Huan Xiong Xiao-Lian Zhang 
the Animal Biosafety Level 3 Laboratory(ABSL-III)of the Wuhan University School of Medicine(NO.18021B);the Second Military Medical University of Shanghai(No.18002)for their help with the M.tb infection experiment;This project was supported by grants from the National Grand Program on Key Infectious Disease of China(2017ZX10201301-006 and 2012ZX10003002-015);the National Key R&D Program of China(2018YFA0507603);the National Natural Science Foundation of China(91740120,22077097 and 21721005);the National Outstanding Youth Foundation of China(81025008);Hubei Province’s Outstanding Medical Academic Leader Program(523-276003);Hubei Province Key R&D Program(2020BCB020);Research and Innovation Team Project of Hubei Provincial Health Commission(WJ2021C002);the Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University(TFJC 2018002);the Fundamental Research Funds for the Central Universities.
Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of intracellular pathogens. However, the role andmechanism of the important lncRNAs in Mycobacterium tuberculosis (M.tb) infection remain largely ...
关键词：Mycobacterium tuberculosis lncRNA PYROPTOSIS CYTOKINES 
N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties:Design,synthesis and antitubercular activity被引量：1
《Chinese Chemical Letters》2020年第2期409-412,共4页Linhu Li Apeng Wang Bin Wang Mingliang Liu Kai Lv Zeyu Tao Chao Ma Xican Ma Bing Han Aoyu Wang Yu Lu 
supported by the CAMS Innovation Fund for Medical Science(No.CAMS-2017-I2M-1-011);National Mega-project for Innovative Drugs(Nos.2015ZX09102007-008,2018ZX09721001004-007,2018ZX09711001-007-002);the National Natural Science Foundation of China(No.81872753)。
Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activit...
关键词：N-(2-Phenoxy)ethyl imidazo[1 2-α]pyridine DESIGN SYNTHESIS ANTIMYCOBACTERIAL activity 
Design,synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
《Chinese Chemical Letters》2019年第2期413-416,共4页Hongjian Wang Kai Lv Xiaoning Li Bo Wang Apeng Wang Zeyu Tao Yunhe Geng Bin Wang Menghao Huang Mingliang Liu Huiyuan Guo Yu Lu 
supported by the National Mega-project for Innovative Drugs(Nos.2015ZX09102007-008,2015ZX09102007015,2015ZX0 9304006-016,2018ZX09721001-004-007, 2018ZX09711001-007-002);CAMS Initiative for Innovative Medicine(No.2016-I2M-1-010);CAMS Innovation Fund for Medical Science(Nos.CAMS-2016-I2M-1-010,CAMS-2017-I2M-1-011);PUMC Youth Fund (No. 2017350011)
We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N- (pyridine-2-yl)met...
关键词：Nitrobenzamides SYNTHESIS ANTIMYCOBACTERIAL activity TUBERCULOSIS 
Potential applications of lactic acid bacteria and bacteriocins in antimycobacterial therapy被引量：3
《Asian Pacific Journal of Tropical Medicine》2018年第8期453-459,共7页Anbarasu Sivaraj Revathy Sundar Radhakrishnan Manikkam Krupakar Parthasarathy Uma Rani Vanaja Kumar 
supported by Sathyabama Institute of Science and Technology,Chennai,Tamil Nadu,India and Indian Council of Medical Research(ICMR),New Delhi,India(Ref.No:5/8/5/19/2014-ECD-I)
Tuberculosis(TB) is a communicable disease caused by Mycobacterium tuberculosis(M. tuberculosis). WHO estimated that 10.4 million new(incident) TB cases worldwide in year 2016. The increased prevalence of drug resista...
关键词：BACTERIOCIN Lactic acid bacteria Antimycobacterial peptides TUBERCULOSIS IMMUNOMODULATION Hybrid bacteriocin 
Antimycobacterial natural products from Moroccan medicinal plants: Chemical composition, bacteriostatic and bactericidal profile of Thymus satureioides and Mentha pulegium essential oils被引量：3
《Asian Pacific Journal of Tropical Biomedicine》2016年第10期836-840,共5页Marwa Chraibi Abdellah Farah Sara Lebrazi Oumaima El Amine Mohammed Iraqui Houssaini Kawtar Fikri-Benbrahim 
Supported by the Cooperation for Innovation in the Agro-Food Domain Project within the 7th Research and Development Framework Programme FP7-INCO-2013-9(Grant agreement number 609495)
Objective: To evaluate the susceptibility of Mycobacterium aurum and Mycobacterium smegmatis in vitro to the essential oils obtained from two medicinal plants: Thymus satureioides(T. satureioides) and Mentha pulegium(...
关键词：THYMUS satureioides MENTHA pulegium Essential oil Chemical composition ANTIMYCOBACTERIAL activity 
Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives被引量：2
《Chinese Chemical Letters》2016年第3期365-369,共5页Nagabhushana Nayak Jurupula Ramprasad Udayakumar Dalimba Perumal Yogeeswari Dharmarajan Sriram 
National Institute of Technology Karnataka,India for the financial support and laboratory facility
This article demonstrates the synthesis, characterization and the study of in vitro antitubercular activities of twenty four new N-（4-（5-aryl-3-（5-methyl-1,3,4-oxadiazol-2-yl）-1H-pyrazol-1-yl）phenyl）-4-amide der...
关键词：Pyrazole-oxadiazole hybrids Antitubercular activity SC-XRD analysis In vitro cytotoxicity 
Evaluation of antimycobacterium activity of the essential oils of cumin (<i>Cuminum cyminum</i>), clove (Eugenia caryophyllata), cinnamon (<i>Cinnamomum verum</i>), laurel (<i>Laurus nobilis</i>) and anis (<i>Pimpinella anisum</i>) against <i>Mycobacterium tuberculosis</i>
《Advances in Biological Chemistry》2013年第5期480-484,共5页Andrade-Ochoa Sergio Chacón-Vargas Fabiola Nevarez-Moorillon Guadalupe Rivera-Chavira Blanca Hernández-Ochoa León 
In this study Essential oils were used with cumin, cloves, cinnamon, laurel and anis to determine Minimum Inhibitory Concentration (MIC) against Mycobacterium tuberculosis strains. The MICs were determined on M. tuber...
关键词：ANTIMYCOBACTERIAL ACTIVITY Essential Oils MONOTERPENOIDS Mycobacterium tuberculosis 
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