financially supported by the National Natural Science Foundation of China(82070712,81873603 to LML);the Science and Technology Commission of Shanghai Municipality(14DZ2260200,the Project of Shanghai Key Laboratory of Kidneyand Blood Purification).
Acute kidney injury(AKl)is a worldwide public health problem characterized by the massive loss of tubular cells.However,the precise mechanism for initiating tubular cell death has not been fully elucidated.Here,we rep...
This study was funded by Incubation foundation of Capital Medical University(PYZ2018061);Nature and Sciences Foundation of China(81430044,81974183,81930054,82072104).
Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosp...
Supported by the 13th FIVE-YEAR Key Project for Traditional Chinese Medicine of Zhejiang Province,No.2A11951;Basic Public Welfare Research Program of Zhejiang Province,No.LGF21H020002;Clinical Research Fund of Zhejiang Medical Association,No.2020ZYCA03;Traditional Chinese Medicine Scientific Research Fund Project of Zhejiang Province,No.2021ZA038.
BACKGROUND Globally,the estimated annual incidence of snakebites is approximately 5 million,and approximately 100000 deaths occur from snakebites annually.Local tissue reaction,haemorrhagic clotting disorder,nephrotox...
Endovascular treatment is increasingly employed as the treatment for symptomatic aortoiliac occlusive disease.One of the possible complications of aortoiliac stenting is the development of emboli.We present a case of ...
BACKGROUND Anastomotic leaks(AL)and gastric conduit necrosis(CN)are serious complications following oesophagectomy.Some studies have suggested that vascular calcification may be associated with an increased AL rate,bu...
Purpose: To determine the prevalence, identify the causes and outline the management options available at our center for the treatment of neovascular glaucoma. Setting: The study was carried out in the department of o...
BACKGROUND Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents.Although withdrawal of the causative agent would cure the disease ...
a grant of National Natural Science Foundation of China (No.81471885).
Background:Necroptosis is a new form of cell death that has been identified as a third pathway causing cell death.In this study,necrostatin-1 (Nec-1) was used to determine whether necroptosis exists in a rat ischaemia...
This work was supported by grants from the Seed Grant of International Alliance of Translational Neuroscience(PXM-2014-014226-000006);Beijing Natural Science Foundation(7132070 and 7141001);National Natural Science Foundation of China(81771414,81301015,31471142 and 31671205).
Introduction Cerebral ischaemia-induced depression is among the most frequent neuropsychiatric consequences and adversely impact the prognosis and recovery of patients.Although several brain regions have been implied ...
Purpose: Gut permeability and microvascular injury following ischaemia/reperfusion (IR) have been implicated in the systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF). Taurine (TAU), a sul...