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Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinﬂammation via inhibition of NF-κB signaling pathway: 《Chinese Journal of Natural Medicines》2024年第5期441-454,共14页SHAO Siyuan SUN Mohan MA Xianjie JIANG Jianwei TIAN Jinying ZHANG Jianjun YE Fei LI Shuai; This research was supported by the National Natural Science Foundation of China(No.81903488);the CAMS Innovation Fund for Medical Sciences(No.CIFMS-2021-I2M-1-026)。; Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla striata.Their structures were elucidated through c...; 关键词：Bletilla striata Phenanthrene/bibenzyl trimer NO inhibition AKT/IκB/NF-κB signaling pathway PTP1B inhibitory effect

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3被引量：5: 《Natural Products and Bioprospecting》2022年第1期1-11,共11页Ding-kang Chen Hui-yan Shao Liu Yang Jiang-miao Hu; supported by Biological Resources Programme,Chinese Academy of Sciences (Grant No.KFJ-BRP-007-019);National Natural Science Foundation of China (No.32170407) and Beijing DR PLANT Biotechnology Co.,Ltd.; Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine.The chemical constituents of D.officinale have attracted much attention and a large number of compounds have been ...; 关键词：Dendrobium officinale Bibenzyl derivatives Skin photoaging Oxidative stress SIRT3

20C,a new bibenzyl compound,plays a significant role in rotenone-induced oxidative insult: 《中国药理学与毒理学杂志》2017年第10期1008-1009,共2页Xiao-ling ZHANG Yu-he YUAN Nai-hong CHEN; supported by National Natural Science Foundation of China(U1402221,81573640,81603316);Beijing Natural Science Foundation(7161011);CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150);Key Research and Development Project of Hunan Province(2015SK2029-1);Scientific Research Foundation of the Higher Education Institutions of Hunan Province(15K091); 20C,a bibenzyl compound isolated from Gastrodia elata,possesses antioxidative properties in PC12 cells,but its in-depth molecular mechanisms against rotenone-induced neurotoxicity remains unknown.Recent studies indica...; 关键词：20C Parkinson disease DJ-1 Akt oxidative stress nuclear factor erythroid 2-related factor(Nrf2)

Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro被引量：6: 《Acta Pharmacologica Sinica》2016年第12期1525-1533,共9页Zheng MOU Yu-he YUAN Yu-xia LOU Yang HENG Ju-yang HUANG Cong-yuan XIA Yan GAO Cheng-gen ZHU Shi-feng CHU Piao LUO Jian-gong SHI Nai-hong CHEN; This work was supported by the National Natural Science Foundation of China （No 81274122, 81373997, 81273629, 81473376, U1402221, and 81573640）, the National Mega-project for Innovative Drugs （No 2012ZX09301002-004）, the Program for Changjiang Scholars and Innovative Research Team in University （PCSIRT）（No IRT1007）, Beijing Natural Science Foundation （No 7131013 and 7161011）, and the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study （No BZ0150）.; Aim： Accumulation of α-synuclein （a-syn） in the brain is a characteristic of Parkinson＇s disease （PD）. In this study, we investigated whether treatment with tunicamycin, an endoplasmic reticulum （ER） stress i...; 关键词：Gastrodia elata bibenzyl compound 20c PC12 cells TUNICAMYCIN Α-SYNUCLEIN ER stress Parkinson＇s disease NEUROPROTECTION

20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway被引量：16: 《Acta Pharmacologica Sinica》2016年第6期731-740,共10页Ju-yang HUANG Yu-he YUAN Jia-qing YAN Ya-nan WANG Shi-feng CHU Cheng-gen ZHU Qing-lan GUO Jian-gong SHI Nai-hong CHEN; Aim： Our preliminary study shows that a bibenzyl compound isolated from Gastrodia elata, 2-[4-hydroxy-3-（4-hydroxybenzyl）benzyl]-4-（4-hydroxybenzyl）phenol （designated 20C）, protects PC12 cells against H202-indu...; 关键词：bibenzyl compound Gastrodia elata ROTENONE apoptosis oxidative stress Nrf2 NEUROPROTECTION Parkinson＇s disease PC12 cells

Antifungal variant bis(bibenzyl)s from the liverwort Asterella angusta: 《Chinese Chemical Letters》2013年第9期801-803,共3页Jian-Bo Qu Ling-Mei Sun Hong-Xiang Lou; supported by the National Natural Science Foundation of China(No.30925038); Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis（bibenzyl）s, riccardin I （1）, and angustatin A （2）. Their structures were e...; 关键词：Variant bis（bibenzyl）s Asterella angusta Antifungal activity

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities被引量：6: 《Natural Products and Bioprospecting》2013年第2期70-73,共4页Cheng-Bo LI Cong WANG Wei-Wei FAN Fa-Wu DONG Feng-Qing XU Qin-Li WAN Huai-Rong LUO Yu-Qing LIU Jiang-Miao HU Jun ZHOU; National Natural and Science Foundations of China(No.30800090);"Xi-Bu-Zhi-Guang"project(2009-2012)from Chinese Academy of Science and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ012).; 15 compounds,including two new ones crepidatuols A(1)and B(2)were isolated from the stems of Dendrobium crepidatum.The planar structures of these compounds were elucidated by spectroscopic methods(NMR,MS,UV,and IR)and...; 关键词：ORCHIDACEAE Dendrobium crepidatum BIBENZYL neurite outgrowth enhancing activity

Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl, and polysaccharides被引量：27: 《Science China(Life Sciences)》2012年第12期1092-1099,共8页CHEN XiaoMe WANG FangFei WANG YunQiang LI XueLan WANG AiRong WANG ChunLan GUO ShunXing; supported by the National Natural Science Foundation of China (Grant Nos. 30830117 and 31170016) ;the Major Scientific and Technological Special Project for Significant New Drugs Creation (Grant No. 2012ZX09301002-001-031); The aim of this study was to establish a method for discriminating Dendrobium officinale from four of its close relatives Den- drobium chrysanthum, Dendrobium erystallinum, Dendrobium aphyllum and Dendrobium devonianu...; 关键词：Dendrobium officinale NARINGENIN BIBENZYL POLYSACCHARIDE discriminant analysis

An efficient oxidation of benzylic and alicylic compounds with water-soluble copper catalysts in t-butyl hydroperoxide at room temperature被引量：1: 《Chinese Chemical Letters》2011年第6期691-693,共3页Ateeq Rahman S.M.Al Zahrani Abdel Aziz Nait Ajjou; Authors acknowledge NSERC of Canada and Department of Chemical Engineering,King Saud University,Riyadh, Kingdom of Saudi Arabia for their support; The water soluble catalytic system comprising of CuCl_2 and 2,2-biquinoline-4,4-dicarboxylic acid dipotassium salt（BQC） is highly efficient organic metallic catalysts for selective oxidation of benzyiic and alicycii...; 关键词：OXIDATION BIBENZYL Allyl benzene INDAN 2-Biquinoline-4 4-dicarboxylic acid dipotassium salt（BQC） Tetrabutyl ammonium bromide（TBAC）

Effect of plagiochin E, an antifungal macrocyclic bis（bibenzyl）, on cell wall chitin synthesis in Candida albicans被引量：7: 《Acta Pharmacologica Sinica》2008年第12期1478-1485,共8页Xiu-zhen WU Ai-xia CHENG Ling-mei SUN Hong-xiang LOU; This work was supported by the National Basic Research Program （973 Program） of China （No 2006CB708511） and the National Natural Science Foundation of China （No 30730109 and 30672531）.Acknowledgements We thank Shu-juan SUN of Shandong Provincial Qianfoshan Hospital of China for donating the yeast isolates, and Bo-qin LI and Lei WANG for excellent technical assistance.; Aim： To investigate the effect of plagiochin E （PLE）, an antifungal macrocyclic bis（bibenzyl） isolated from liverwort Marehantia polymorpha L, on cell wall chitin synthesis in Candida albicans. Methods： The effe...; 关键词：plagiochin E macrocyclic bis（bibenzyl） Candida albicans cell wall chitin synthesis

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