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作品数:640被引量:3146H指数:21
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相关领域:医药卫生生物学更多>>
相关作者:李建磊郭静杨雅阁王书奎李修成更多>>
相关机构:北京大学复旦大学澳门科技大学武汉大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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  • 期刊=Cell Researchx
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Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
《Cell Research》2025年第2期117-131,共15页Wei Fu Yuanting Lai Kexin Li Yue Yang Xiao Guo Qifan Gong Xiaofeng Zhou Liying Zhou Cenxi Liu Zhi Zhang Jisun So Yufeng Zhang Lin Huang Guangxing Lu Chuanyou Yi Qichu Wang Chenyu Fan Chao Liu Jiaxing Wang Haiyi Yu Yimin Zhao Tao Huang Hyun Cheol Roh Tiemin Liu Huiru Tang Jianping Qi Ming Xu Yan Zheng He Huang Jin Li 
supported by the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803800,2019YFA0801900,NSFC92057115);Shanghai Sailing Program 20YF1402600 to H.H.,the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803600,2018YFA0801300,2023YFA1801000 to J.L.);the National Natural Science Foundation of China(32071138 and 32371193 to J.L.),and SKLGE-2118 to J.L.
Neurotensin(NTS)is a secretory peptide produced by lymphatic endothelial cells.Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2.In the current study,we f...
关键词:INTAKE METABOLISM Together 
α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy
《Cell Research》2025年第1期72-75,共4页Qianhui Xu Huilan Wang Ruonan Yang Youqi Tao Ziying Wang Shengnan Zhang Bo Sun Dan Li Boxun Lu Cong Liu 
supported by the National Natural Science Foundation(NSF)of China(82188101 and 32171236 to C.L.;92353302 and 32170683 to D.L.;81925012,92049301 to B.L.);the Science and Technology Commission of Shanghai Municipality(STCSM)(22JC1410400 to C.L.);the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-005 to C.L.);the CAS Project for Young Scientists in Basic Research(YSBR-095 to C.L.);Shanghai Basic Research Pioneer Project to C.L,the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07.E00074 to B.L.).
Dear Editor,Parkinson’s disease(PD)is a progressive neurodegenerative disorder,which manifests through the abnormal accumulation of pathological amyloid fibrils composed of α-synuclein(α-syn)into Lewy bodies and th...
关键词:AMYLOID LC3B selective 
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression被引量:15
《Cell Research》2023年第4期299-311,共13页Shiqiao Qiu Xiuying Zhong Xiang Meng Shiting Li Xiaoyu Qian Hui Lu Jin Cai Yi Zhang Mingjie Wang Zijian Ye Huafeng Zhang Ping Gao 
supported by the National Natural Science Foundation of China(91957203,81930083,82130087,82072656,82192893,81821001);the National Key R&D Program of China(2018YFA0800303,2022YFA1304504);the Chinese Academy of Sciences(XDB39000000);Hefei Comprehensive National Science Center Institute of Health and Medicine Project(DJK-LX-2022001).
A well-established role of cyclic GMP-AMP synthase(cGAS)is the recognition of cytosolic DNA,which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes(STING)-depend...
关键词:INTERFERON STIMULATOR cGAS 
Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis被引量:2
《Cell Research》2023年第3期245-257,共13页Wencheng Zhu Huiying Chu Yajuan Zhang Tianhang Luo Hua Yu Hongwen Zhu Ye Liu Hong Gao Yun Zhao Quanlin Li Xiongjun Wang Guohui Li Weiwei Yang 
This work was supported by the National Natural Science Foundation of China(92253305,92053203 and 32025013)to W.Y.;the National Key R&D Program of China(2022YFA0806201 and 2019YFA0802000)to W.Y.;CAS Project for Young Scientists in Basic Research(YSBR-014)to W.Y.;Program of Shanghai Academic/Technology Research Leader(20XD1424400)to W.Y.;the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212302)to W.Y.;the Strategic Priority Research Program of Chinese Academy of Sciences(XDB 37000000)to G.L.;the National Natural Science Foundation of China(21933010)to G.L.;the National Natural Science Foundation of China(21907094)to H.C.;the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022265)to Y.Zhang;Shanghai Science and Technology Development Funds(22QA1409900)to Y.Zhang.We gratefully acknowledge the support of the Sanofi Scholarship Program.We also thank all the core facilities of Shanghai Institute of Biochemistry and Cell Biology for technical support.
Emerging evidence demonstrates that some metabolic enzymes that phosphorylate soluble metabolites can also phosphorylate a variety of protein substrates as protein kinases to regulate cell cycle,apoptosis and many oth...
关键词:IΚBΑ COLORECTAL STIMULATION 
Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity被引量:10
《Cell Research》2021年第9期1028-1031,共4页Guangya Zhu Jingjinq Xie Zhenzhen Fu Mingliang Wang Qichen Zhang Hao He Zijun Chen Xin Guo Jidong Zhu 
This work was supported by the National Key R&D Program of China(2016YFA0501900);the National Natural Science Foundation of China(21532002 and 21877123);the Shanghai Municipal Science and Technology Major Project(2019SHZDZX02);the joint postdoc program with Janssen R&D.
Dear Editor,Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse typ...
关键词:SEPARATION PHARMACOLOGICAL phase 
A novel satiety sensor detects circulating glucose and suppresses food consumption via insulin-producing cells in Drosophila被引量:1
《Cell Research》2021年第5期580-588,共9页Wei Qi Gaohang Wang Liming Wang 
This study was funded by the National Key R&D Program of China(2019YFA0801900 and 2019YFA0802400);the National Natural Science Foundation of China(31522026).
Sensing satiety is a crucial survival skill for all animal species including human.Despite the discovery of numerous neuromodulators that regulate food intake in Drosophila,the mechanism of satiety sensing remains lar...
关键词:ELEVATED HOMEOSTASIS feeding 
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression被引量:262
《Cell Research》2019年第10期787-803,共17页Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng 
Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential m...
关键词:inflammation ALZHEIMER SHAPED 
Siglecl suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27被引量:26
《Cell Research》2015年第10期1121-1136,共16页Qingliang Zheng Jin Hou Ye Zhou Yingyun Yang Bing Xie Xuetao Cao 
Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations o...
关键词:Siglec 1 innate immune response type I interferon TBK1 TRIM27 
RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect被引量:4
《Cell Research》2015年第9期1025-1042,共18页Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin 
Hypoxia-inducible factors (HIFs) are master regulators of adaptive responses to low oxygen, and their a-subunits are rapidly degraded through the ubiquitination-dependent proteasomal pathway after hydroxylation. Abe...
关键词:RHOBTB3 HIF PHD VHL HYDROXYLATION UBIQUITINATION the Warburg effect 
SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer被引量:4
《Cell Research》2015年第4期445-458,共14页Andreas I Papadakis Chong Sun Theo A Knijnenburg Yibo Xue Wipawadee Gremrum Michael Holzel Wouter Nijkamp Lodewyk FA Wessels Roderick L Beijersbergen Rene Bernards Sidong Huang 
Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways...
关键词:EGFR signaling drug resistance RNAi screening SMARCE 1 SWI/SNF 
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