supported by the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803800,2019YFA0801900,NSFC92057115);Shanghai Sailing Program 20YF1402600 to H.H.,the National Key R&D Program of China from Ministry of Science&Technology(2020YFA0803600,2018YFA0801300,2023YFA1801000 to J.L.);the National Natural Science Foundation of China(32071138 and 32371193 to J.L.),and SKLGE-2118 to J.L.
Neurotensin(NTS)is a secretory peptide produced by lymphatic endothelial cells.Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2.In the current study,we f...
supported by the National Natural Science Foundation(NSF)of China(82188101 and 32171236 to C.L.;92353302 and 32170683 to D.L.;81925012,92049301 to B.L.);the Science and Technology Commission of Shanghai Municipality(STCSM)(22JC1410400 to C.L.);the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-005 to C.L.);the CAS Project for Young Scientists in Basic Research(YSBR-095 to C.L.);Shanghai Basic Research Pioneer Project to C.L,the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07.E00074 to B.L.).
Dear Editor,Parkinson’s disease(PD)is a progressive neurodegenerative disorder,which manifests through the abnormal accumulation of pathological amyloid fibrils composed of α-synuclein(α-syn)into Lewy bodies and th...
supported by the National Natural Science Foundation of China(91957203,81930083,82130087,82072656,82192893,81821001);the National Key R&D Program of China(2018YFA0800303,2022YFA1304504);the Chinese Academy of Sciences(XDB39000000);Hefei Comprehensive National Science Center Institute of Health and Medicine Project(DJK-LX-2022001).
A well-established role of cyclic GMP-AMP synthase(cGAS)is the recognition of cytosolic DNA,which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes(STING)-depend...
This work was supported by the National Natural Science Foundation of China(92253305,92053203 and 32025013)to W.Y.;the National Key R&D Program of China(2022YFA0806201 and 2019YFA0802000)to W.Y.;CAS Project for Young Scientists in Basic Research(YSBR-014)to W.Y.;Program of Shanghai Academic/Technology Research Leader(20XD1424400)to W.Y.;the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212302)to W.Y.;the Strategic Priority Research Program of Chinese Academy of Sciences(XDB 37000000)to G.L.;the National Natural Science Foundation of China(21933010)to G.L.;the National Natural Science Foundation of China(21907094)to H.C.;the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022265)to Y.Zhang;Shanghai Science and Technology Development Funds(22QA1409900)to Y.Zhang.We gratefully acknowledge the support of the Sanofi Scholarship Program.We also thank all the core facilities of Shanghai Institute of Biochemistry and Cell Biology for technical support.
Emerging evidence demonstrates that some metabolic enzymes that phosphorylate soluble metabolites can also phosphorylate a variety of protein substrates as protein kinases to regulate cell cycle,apoptosis and many oth...
This work was supported by the National Key R&D Program of China(2016YFA0501900);the National Natural Science Foundation of China(21532002 and 21877123);the Shanghai Municipal Science and Technology Major Project(2019SHZDZX02);the joint postdoc program with Janssen R&D.
Dear Editor,Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse typ...
This study was funded by the National Key R&D Program of China(2019YFA0801900 and 2019YFA0802400);the National Natural Science Foundation of China(31522026).
Sensing satiety is a crucial survival skill for all animal species including human.Despite the discovery of numerous neuromodulators that regulate food intake in Drosophila,the mechanism of satiety sensing remains lar...
Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential m...
Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations o...
Hypoxia-inducible factors (HIFs) are master regulators of adaptive responses to low oxygen, and their a-subunits are rapidly degraded through the ubiquitination-dependent proteasomal pathway after hydroxylation. Abe...
Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways...