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Nootkatone suppresses TLR4/NF-κB/NLRP3 pathway to alleviate non-alcoholic fatty liver disease via modulating gut microbiota
《Food Science and Human Wellness》2025年第4期1398-1410,共13页Rongrong Fu Wenqing Xue Jingjie Liang Lechen Wang Min Zhang Jing Meng 
supported by grants from National Natural Science Foundation of China(82072709,81902441);Natural Science Foundation of Tianjin Municipal(23JCYBJC00850);China Postdoctoral Science Foundation(2022M712374);Tianjin“131”Innovative Talent Team Project(201926)。
Non-alcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases worldwide.Gut microbiota and its metabolites alteration are closely related to NAFLD.Nootkatone is an edible flavorant derived f...
关键词：Nootkatone Non-alcoholic fatty liver disease Hepatic inflammation TLR4/NF-κB/NLRP3 Gut microbiome 
TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERαexpression in triple-negative breast cancer
《Genes & Diseases》2025年第2期37-40,共4页Shang Gao Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li Ruonan Duan Jiangxia Li Qiji Liu 
supported by grants from the National Key R&D Program of China (No.2022YFC2703701 to Qiji Liu);the National Natural Science Foundation of China (No.82271901,32070586);the Shandong Provincial Natural Science Foundation,China (No.ZR2020MH086);Taishan Scholar Program of Shandong Province (tsqn202211318);NHC Key Laboratory of Birth Defects Prevention,China (No.ZD202101).
Triple-negative breast cancer(TNBC)is defined by the lack of estrogen receptor(ER),progesterone receptor,and amplified human epidermal growth factor receptor expression.TNBC accounts for~15%of all breast cancer cases ...
关键词：expression. BREAST cancer 
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
《Genes & Diseases》2025年第2期64-67,共4页Yue Weng Xiangyu Yan Biying Chen Zhouliang Bian Yunhui Ge Hong Lu Shufang He Jian Wu Yong Chen Ming Lei Yanjie Zhang 
supported by grants from the National Natural Science Foundation of China (No.31930063 to Ming Lei,82072638 to Yanjie Zhang,32100582 to Yunhui Ge);Innovative Research Team of High-level Local University in Shanghai,China (No.SHSMU-ZLCX20211700 to Ming Lei);Shanghai Municipal Health Commission and Collaborative Innovation Cluster Project (China) (No.2019CXJQ01 to Ming Lei).
Telomerase plays an essential role in the immortalization and stemness of cancer cells.PIN2/TRF1-interacting telomerase inhibitor 1(PinX1)functions as a telomerase inhibitor and tumor suppressor.1 However,the underlyi...
关键词：PinX1 CERVICAL CANCER 
Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway
《Genes & Diseases》2025年第2期86-89,共4页Haixia Luo Jingjing Chang Yiting Ren Xiu Zhang Yuanxing Li Miao Huo Hongyuan Wang Xin Yang Jianbing Liu Qingmei Zhang Yueyang Zhao Wei Wang 
supported by grants from the Applied Basic Research Program of Shanxi,China (No.20210302123277);the Key Research and Development Program of Shanxi,China (No.201903D321152);the National Natural Science Foundation of China (No.82373107).
Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this...
关键词：METASTASIS ITG cancer 
Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity
《Food Science and Human Wellness》2025年第2期651-661,共11页Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang 
supported by Natural Science Foundation of Guangdong Province,China(2022A1515011575);National Natural Science Foundation of China,China(81873154);President Foundation of Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,China(1202103010)。
Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSC...
关键词：Lycii Radicis Cortex Non-small cell lung cancer PD-L1 Immune checkpoint 
Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling
《Science China(Life Sciences)》2025年第3期593-609,共17页Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua Zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang 
supported by grants from the National Key R&D Program of China(2021YFF0501401,2018YFA0800501);National Natural Science Foundation of China(82325004,92168114,82172447);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0047).
Diffuse-type tenosynovial giant cell tumor(dTGCT)is a destructive but rare benign proliferative synovial neoplasm.Although surgery is currently the main treatment modality for dTGCT,the recurrence risk is up to 50%.Th...
关键词：dTGCT JAK/STAT signaling peficitinib TYK2 FLS MACROPHAGES 
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling
《Research》2025年第1期752-764,共13页Youxia Wang Xinmei Zhang Ifen Hung Chunxue Liu Wenkai Ren Liangpeng Ge Hao Wang 
supported by the National Natural Science Foundation of China(U22A20510 and 32225047);Laboratory of Lingnan Modern Agriculture Project(NT2021005);Double first-class discipline promotion project(2023B10564001);National Center of Technology Innovation for Pigs(NCTIP-XD/B13).
The prevalence of food allergies is increasing dramatically and causing serious public health concerns.Notably,melatonin metabolism imbalance in patients with food allergies;however,the role of melatonin in food aller...
关键词：food allergieshoweverthe degranulation mast cells reprograms gut microbiota gut microbiota food allergy aggravates food allergy suppresses food allergy MELATONIN 
SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells
《World Journal of Gastroenterology》2025年第10期118-133,共16页Jia-Nan Chen Li Wang Yu-Xin He Xiao-Wei Sun Long-Jiao Cheng Ya-Nan Li Sei Yoshida Zhong-Yang Shen 
Supported by the National Natural Science Foundation of China,No.82241219,No.82127808 and No.81921004;The Shenzhen Science and Technology Program,No.JCYJ20210324120813037.
BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and secretion.Endoplasmic reticulum-associated protein degradation(ERAD)is crucial for monitorin...
关键词：Hepatocellular carcinoma Endoplasmic reticulum stress Endoplasmic reticulum-associated protein degradation SEL1L EXT2 
LN-439A,a novel BAP1 inhibitor,suppresses the growth of basal-like breast cancer by degrading KLF5
《Acta Pharmacologica Sinica》2025年第3期715-727,共13页Tian-tian Wang Long-long Zhang Fu-bing Li Jie Zhang Zhi-bi Zhang Da-zhao Mi Jian Sun Hong-yan Zhang Chun-yan Wang Yi-hua Chen Ce-shi Chen 
supported by National Key Research and Development Program of China(2020YFA0112300,2023YFA1800403);the National Natural Science Foundation of China(U2102203,82260691,82160461,82472806);the Biomedical Projects of Yunnan Key Science and Technology Program(202302AA310046);the Yunnan Revitalization Talent Support Program(Yunling Shcolar Project to CC),Yunnan(Kunming)Academician Expert Workstation(YSZJGZZ-2020025 to CC);the Key Research and Development Program of Ningxia(2023BEG02010);the Yunnan Fundamental Research Projects(202401AT070171);the Technology Innovation Team of Pathological Diagnosis of Triple Negative Breast Cancer in Kunming Medical University(grant number CXTD202208);Yunnan Revitalization Talent Support Program,Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University(202401AY070001-026).
Basal-like breast cancer(BLBC)is the most malignant subtype of breast cancer because of its aggressive clinical behaviour and lack of effective targeted agents.Krüppel-like factor 5(KLF5)is an oncogenic transcription...
关键词：BLBC LN-439A KLF5 BAP1 DEUBIQUITINATION 
Resveratrol promotes mitophagy via the MALAT1/miR-143-3p/RRM2 axis and suppresses cancer progression in hepatocellular carcinoma
《Journal of Integrative Medicine》2025年第1期79-92,共14页Chun-yan Feng Cheng-song Cai Xiao-qian Shi Zhi-juan Zhang Dan Su Yun-qing Qiu 
supported by the Zhejiang Provincial Science and Technology Department Key Research and Development Plan(No.2020C03046).
Objective Resveratrol(Res)is a promising anticancer drug against hepatocellular carcinoma(HCC),but whether its anti-HCC effects implicate mitophagy remains unclear.Therefore,we aimed to explore the specific role of Re...
关键词：Hepatocellular carcinoma RESVERATROL MITOPHAGY MALAT1 miR-143-3p 
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