GENOME-WIDE

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Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma
《Genes & Diseases》2024年第5期51-54,共4页Hongying Zhao Ying Liu Meiting Fei Lin Bo Lixia Wang Yaopeng Shu Peiqi Ben Li Wang 
1the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province,China(No.UNPYSCT-2020174);the Excellent Youth Project of Provincial Scientific Research Institute(China)(No.CZKYF2022-1-C006);the Hei Long Jiang Postdoctoral Special Foundation(China)(No.LBH-TZ1018).
Glioblastoma(GBM)is the most common primary malignant intracranial tumor with a very poor prognosis.In this study,we systematically analyzed the DNA methylation alterations of autophagy-related lncRNAs and their assoc...
关键词：regulated alterations DRUGS 
Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第4期324-340,共17页Natalia V.DEMENTIEVA Yuri S.SHCHERBAKOV Olga I.STANISHEVSKAYA Anatoly B.VAKHRAMEEV Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAEVA Anna E.RYABOVA Anastasiia I.AZOVTSEVA Olga V.MITROFANOVA Grigoriy K.PEGLIVANYAN Natalia R.REINBACH Darren K.GRIFFIN Michael N.ROMANOV 
supported by the Ministry of Science and Higher Education of the Russian Federation(No.075-152021-1037,Internal No.15.BRK.21.0001)。
The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse origin.This study was a large-scale genome-wide analysis of the landscape of the complex molecula...
关键词：Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry PHYLOGENY Demographic history 
Genome-wide association mapping in a sweet cherry germplasm collection(Prunus avium L.)reveals candidate genes for fruit quality traits
《Horticulture Research》2023年第10期227-249,共23页Armel S.L.Donkpegan Anthony Bernard Teresa Barreneche José Quero-García Hélène Bonnet Mathieu Fouché Loïck Le Dantec Bénédicte Wenden Elisabeth Dirlewanger 
We thank the Prunus/Juglans Biological Resources Center managed by the INRAE Fruit Tree Experimental Unit for performing part of the phenotyping and for maintenance of the collection.This work was supported by the Région Nouvelle-Aquitaine with the project CerGEn reference 2018-1R20203,which funded the postdoctoral fellowship for A.S.L.D.
In sweet cherry(Prunus avium L.),large variability exists for various traits related to fruit quality.There is a need to discover the genetic architecture of these traits in order to enhance the efficiency of breeding...
关键词：BREEDING GERMPLASM TRAITS 
Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients
《Precision Clinical Medicine》2022年第3期192-194,共3页Yanqi He Calvin Wei Zhifu Sun Julie M.Cunningham Liang Wang Zong Wei Ping Yang 
support from Mayo Clinic Foundation and U.S.National Cancer Institute(Grants No.R03-77118,R01-80127,and R01-84354)。
Dear Editor,Small-cell lung cancer(SCLC),one of the most-deadly malignant tumors,accounts for∼15%of all lung cancers.1,2 Although highly responsive to the standard chemoradiotherapy,the recurrence rate of SCLC is nea...
关键词：patients diagnosis cancer 
Genome-wide investigation of defensin genes in peanut(Arachis hypogaea L.)reveals AhDef2.2 conferring resistance to bacterial wilt被引量：1
《The Crop Journal》2022年第3期809-819,共11页Kai Zhao Rui Ren Xingli Ma Kunkun Zhao Chengxin Qu Di Cao Qian Ma Yingying Ma Fangping Gong Zhongfeng Li Xingguo Zhang Dongmei Yin 
the National Natural Science Foundation of China(31471525);the Key Program of Natural Science Foundation of China-Henan United Fund(U1704232);Key Scientific and Technological Project in Henan Province(201300111000,S2012-05-G03)。
Peanut(Arachis hypogea L.)bacterial wilt(BW)is a devastating disease caused by Ralstonia solanacearum that results in severe yield and quality losses.Plant defensins are short cysteine-rich peptides with antimicrobial...
关键词：PEANUT Bacterial wilt DEFENSIN Expression analysis Resistance 
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma被引量：5
《Signal Transduction and Targeted Therapy》2022年第3期896-908,共13页Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin 
Supported by National Natural Science Foundation of China(81988101 to D.L.and C.W.);National Science Fund for Distinguished Young Scholars(81725015 to C.W.);Chinese Academy Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-013 to D.L.,C.W.and W.T.,2019-I2M-2-001 to D.L and C.W.);Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.);the National Key R&D Program of China(2021YFC2502000 to Y.L.).
This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparin...
关键词：ESOPHAGEAL SQUAMOUS diagnosis 
Genome-Wide GRAS Gene Family Analysis Reveals the Classification,Expression Profiles in Melon(Cucumis melo L.)被引量：1
《Phyton-International Journal of Experimental Botany》2021年第4期1161-1175,共15页Yanfei Bi Bin Wei Ying Meng Zhongzhao Li Zhenghui Tang Feng Yin Chuntao Qian 
supported by the Science and Technology Project of Suzhou(SNG2017083);the Science and Technology Project of Changshu(CN201701).
Melon(Cucumis melo),belonging to the Cucurbitaceae family,is a globally important economic crop.GRAS(GAI,RGA,SCR)genes,which are a type of transcription factor,play a critical role in plant growth and development,incl...
关键词：Genome-wide identification GRAS MELON stress response 
Genome-wide pedigree analysis of elite rice Shuhui 527 reveals key regions for breeding
《Journal of Integrative Agriculture》2021年第1期35-45,共11页REN Yun CHEN Dan LI Wen-jie TAO Luo YUAN Guo-qiang CAO Ye LI Xue-mei DENG Qiming WANG Shi-quan ZHENG Ai-ping ZHU Jun LIU Huai-nian WANG Ling-xia LI Ping LI Shuang-cheng 
supported by the Sichuan Science and Technology Support Project, China (2016NZ0103);the National Natural Science Foundation of China (91435102 and 31570004);the Sichuan Provincial Founding for Distinguished Young Scholars, China (2015JQ0048);the Open Research Fund of State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, China (2016KF10)。
Hybrid rice significantly contributes to the food supply worldwide. Backbone parents play important roles in elite hybrid rice breeding systems. In this study, we performed pedigree-based analysis of the elite backbon...
关键词：backbone parent Shuhui 527 SNPS genome-wide association study 
A genome-wide identification of the BLH gene family reveals BLH1 involved in cotton fiber development被引量：3
《Journal of Cotton Research》2020年第3期199-209,共11页LIU Cuixia LI Zhifang DOU Lingling YUAN Yi ZOU Changsong SHANG Haihong CUI Langjun XIAO Guanghui 
the State Key Laboratory of Cotton Biology Open Fund(CB2019A03,2019A09 and CB2020A12);the National Natural Science Foundation of China(31872175);the Fundamental Research Funds for the Central Universities(GK202002005 and GK202001004);Natural Science Basic Research Plan in Shaanxi Province of China(2018JZ3006 and 2019JQ-062),Shaanxi Youth Entrusted Talents Program(20190205),Shaanxi Postdoctoral Project(2018BSHYDZZ76);Young Elite Scientists Sponsorship Program by CAST(2019-2021QNRC001).
Background:Cotton is the world’s largest and most important source of renewable natural fiber.BEL1-like homeodomain(BLH)genes are ubiquitous in plants and have been reported to contribute to plant development.However...
关键词：COTTON G.hirsutum BLH gene family Fiber development 
Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antiviral microRNAs被引量：1
《Journal of Genetics and Genomics》2020年第1期49-60,共12页Wenhong Zu Hang Zhang Xun Lan Xu Tan 
supported by the National Natural Science Foundation of China (Grant No. 31670777);the China National Funds for Distinguished Young Scientists (Grant No. 31722030);the Beijing Advanced Innovation Center for Structural Biology to X.T.;the Tsinghua-Peking Joint Center for Life Sciences (Grant No. 61020100119);the National Thousand Young Talents Program of China (Grant No. 042021011) to X.L.
Noncoding RNAs(ncRNAs) play important roles in many biological processes and provide materials for evolutionary adaptations beyond protein-coding genes, such as in the arms race between the host and pathogen. However,...
关键词：Host-virus interaction Positive selection CPG DINUCLEOTIDE Noncoding RNA MicroRNA 
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