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作品数：75被引量：117H指数：7
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Magnetic Field Emulations of Small Inhibitor RNA: Effects on Implanted GL261 Tumors in C57BL/6 Immune Competent Mice
《Open Journal of Biophysics》2024年第4期339-354,共16页Xavier A. Figueroa Gabriel Vogeli B. Michael Butters 
EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine tar...
关键词：Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) Programmed Cell Death Protein 1 (PD-1) Electromagnetic Field Emulation Cancer Tumor Murine Glioblastoma Multiforme (GBM) 
Supporting and retaining competent primary care workforce in low-resource settings:lessons learned from a prospective cohort study被引量：1
《Family Medicine and Community Health》2023年第4期13-35,共23页Mingyue Li Haoqing Tang Huixian Zheng Yiran Tian Xiaoran Cheng Haozhe Cheng Xiaotian Zhang Dan Hu Xiaoyun Liu 
This study involves human participants and was approved by Institutional Review Board of Peking University Health Science Center(PU IRB)(IRB00001052-15027).
Objective Assess whether local health facilities can adequately support the performance of general practitioners(GPs)trained by China’s national compulsory services programme(CSP).Design Prospective cohort study.Sett...
关键词：retaining ADEQUATE FACILITY 
A nanocomposite competent to overcome cascade drug resistance in ovarian cancer via mitochondria dysfunction and NO gas synergistic therapy
《Asian Journal of Pharmaceutical Sciences》2023年第6期144-156,共13页Min Zhong Peiqin Liang Zhenzhen Feng Xin Yang Guang Li Rui Sun Lijuan He Jinxiu Tan Yangpengcheng Xiao Zhiqiang Yu Muhua Yi Xuefeng Wang 
supported by the Guangdong Basic and Applied Basic Research Foundation of China(No.2021A1515011050);President Foundation of The Third Affiliated Hospital of SouthernMedical University[grant number YM202202].
Ovarian cancer(OC)is one of the most common and recurring malignancies in gynecology.Patients with relapsed OC always develop"cascade drug resistance"(CDR)under repeated chemotherapy,leading to subsequent failure of c...
关键词：Cisplatin resistance Patient-derived xenograft model Mitochondrial dysfunction Nitric oxide Ovarian cancer 
Unwavering excellence:How to be a competent cardiovascular doctor in“panvascular medicine+”被引量：1
《The Innovation》2023年第5期30-32,共3页Yiqing Hu Yongchao Zhao Neng Dai Hao Lu Junbo Ge 
Project of Basic Science Center of the National Natural Science Foundation of China,China(approval number:T2288101);Shanghai Clinical Research Center for Interventional Medicine,China(project number:19MC1910300);Research Unit of Cardiovascular Techniques and Devices,Chinese Academy of Medical Sciences,China(project number:2019-I2M-5-060)。
It is essential to create a sustainable and all-encompassing panvascular ecosystem that integrates medical care,industry-academia research,prevention,and management,necessitating the in-depth participation of every ca...
关键词：DOCTOR PREVENTION EDUCATION 
Magnusiomyces capitatus in Immune-Competent Patients with Pulmonary Haemorrhage and Systemic Lupus Erythematosus
《Case Reports in Clinical Medicine》2023年第10期408-417,共10页Waleed Amasaib Ahmed Angham Ahmed Almakki Abeer Ahmed Bashinim Abdelgaffar A. Mohamed Amna Al Kalkami Mohannad AbuRageila 
Invasive fungal infections have grown significantly over the last two decades, owing to an increase in immunocompromised hosts and geriatric patients. When the host’s defenses are compromised, such infections are ass...
关键词：Magnusiomyces capitatus Fungal Infection Bronchoalveolar Lavage Pulmonary Haemorrhage SLE (Systemic Lupus Erythematosus) AMPHOTERICIN A Case Report 
Prolonged Viral Shedding in Three Young Adult Cases of COVID-19
《Infectious Diseases & Immunity》2022年第4期289-292,共4页Wen-Yi Dong Ming-Ju Zhou Lei Huang Chao Zhang Fu-Sheng Wang Zhou-Hua Xie 
supported by the Key Research and Development Program of Guangxi(AB20059001).
Severe acute respiratory syndrome coronavirus-2 infection is usually self-limited,with a short duration for viral shedding within several weeks.However,prolonged viral shedding has been observed in severe or immune-co...
关键词：COVID-19 Immune-competent Prolonged viral shedding SAR-CoV-2 
Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs:a promising therapeutic strategy for HIV cure被引量：1
《Chinese Medical Journal》2021年第23期2776-2787,共12页Silvere D.Zaongo Yue Wang Ping Ma Fang-Zhou Song Yao-Kai Chen 
the Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission(No.2020GDRC004);the Key Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission(No.2019ZDXM012).
Many seminal advances have been made in human immunodeficiency virus(HIV)/AIDS research over the past four decades.Treatment strategies,such as gene therapy and immunotherapy,are yielding promising results to effectiv...
关键词：HIV SECH Latency reversal Autophagy Apoptosis Cell infection inhibition 
In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids被引量：14
《Cell Research》2020年第3期244-255,共12页Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha 
supported by National Key R&D Program(2017YFA0103803);National Natural Science Foundation of China(31890784);National Key R&D Program(2016YFA0500903,2016YFA0503300).
Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro...
关键词：FETAL ORGANS fertility 
Construction of a replication-competent hepatitis B virus vector carrying secreted luciferase transgene and establishment of new hepatitis B virus replication and expression cell lines
《World Journal of Gastroenterology》2019年第39期5961-5972,共12页Jie Ruan Cai-Yan Ping Shuo Sun Xin Cheng Peng-Yu Han Yin-Ge Zhang Dian-Xing Sun 
Supported by the National Natural Science Foundation of China,No.81672041;the National Major Science and Technology Special Project for Infectious Diseases of China,No.2012ZX10004503-012
BACKGROUND Previously,we have successfully constructed replication-competent hepatitis B virus(HBV)vectors by uncoupling the P open reading frame(ORF)from the preC/C ORF to carefully design the transgene insertion sit...
关键词：HEPATITIS B VIRUS Replication-competent HEPATITIS B VIRUS vector SECRETED LUCIFERASE gene HEPATITIS B VIRUS cell line 
Subcutaneous Model for the Study of Dengue Virus Infection in Immune Competent Mice
《Journal of Biosciences and Medicines》2018年第5期97-110,共14页Beatriz Senra Santos Natalia Lima Pessoa Natalia Lucinda Gustavo Cardoso de Oliveira Thais Souza Silva Ketyllen Reis Andrade Ketyllen Reis Andrade Bruno Galvã o Filho Marcele Neves Rocha Alexandre Vieira Machado Pedro Augusto Alves É rica Alessandra Rocha Alves Erna Geessien Kroon Marco Antô nio Campos 
Various mouse models to study dengue have been described by different authors, some of them using immunodeficient or some using humanized mice. Our group reported previously a deadly murine model, which used the intra...
关键词：SUBCUTANEOUS Murine MODEL DENGUE Disease IMMUNE COMPETENT Mouse Cytokines INNATE IMMUNE Response 
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