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Invasive fungal infections have grown significantly over the last two decades, owing to an increase in immunocompromised hosts and geriatric patients. When the host’s defenses are compromised, such infections are ass...
Blastomyces dermatitidis is a dimorphic fungus that typically causes disease in immunocompromised hosts, but can affect immunocompetent patients as well. Here we present a case of disseminated blastomycosis in a pregn...
Importance:Pulmonary mucormycosis is life threatening and carries a poor prognosis.Identification of factors that improve prognosis is urgently necessary.Objective:To analyze the clinical features and outcomes of pulm...
BACKGROUND In recent years,the incidence of fungal infection has been increasing,often invading one or more systems of the body.However,it is rare for lymph nodes to be invaded without the involvement of other organs....
Supported by National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIP),No.2017R1C1B5076640
BACKGROUND Mucormycosis is a very rare fungal infection,and its prognosis is poor.Most common sites of infection are the sinuses,lung,or skin,and gastric involvement is uncommon.The standard antifungal therapy is the ...
Rhizopus is fungus of the order Mucorales, responsible for invasive diseases called mucormycosis. The correct identification of these fungi is one of the main questions raised in the literature since the diagnosis is ...
Mucormycosis is a rare fungal infection which is largely diagnosed in immune-compromised patients. The infection can cause pulmonary, rhinocerebral, skin and soft tissue, central nervous system and gastrointestinal sy...
Objective:Amphotericin B (AMB),a potent antifungal agent,has been employed as topical and systemic therapy for sinonasal fungal infections.A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) ...
We would like to acknowledge C Mooney(NCSU Analytical Instrumentation Facility)for his aid with electron microscopy,B Andersen for her aid with Fourier transform infared spectrosocpy(NCSU College of Textiles),P Strader(NCSU Analytical Instrumentation Facility)for his aid with nanoindentation;the US National Institutes of Health(Award#1R21AI117748-01A1);the US National Science Foundation(Award CMMI 1258536);and the US Office of Naval Research(Award#N00014-15-1-2323);This work was also supported by the National Program PN 4N/2016(1647-LAPLASⅣand a grant of Ministry of Research and Innovation,CNCS–UEFISCDI,Project Number PNIII-P4-ID-PCE-2016-0884,within PNCDIⅢ.
Transdermal delivery of amphotericin B,a pharmacological agent with activity against fungi and parasitic protozoa,is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH val...
Amphotericin B (Am B), a polyene antibiotic, is one of the gold standards for the treatment of systemic fungal infections and leishmaniasis. Nowadays, only intravenous administration of Am B has been available;because...