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GnIH secreted by green light exposure,regulates bone mass through the activation of Gpr147
《Bone Research》2025年第1期212-223,共12页Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo 
National Key Research and Development Program of China(2023YFB3810200 to J.L.);National Natural Science Foundation of China(92168204,82225030 to J.L.);Fundamental Research Funds for the Central Universities(22120210586 to J.L.)。
Reproductive hormones associated with the hypothalamic-pituitary-gonadal(HPG)axis are closely linked to bone homeostasis.In this study,we demonstrate that Gonadotropin inhibitory hormone(GnIH,one of the key reproducti...
关键词：ACTIVATION HOMEOSTASIS GNIH 
Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia
《Protein & Cell》2025年第2期148-155,共8页Mingya Liu Feifei Qi Jue Wang Fengdi Li Qi Lv Ran Deng Xujian Liang Shasha Zhou Pin Yu Yanfeng Xu Yaqing Zhang Yiwei Yan Ming Liu Shuyue Li Guocui Mou Linlin Bao 
supported by the National Research and Development Project of China(grant no.2023YFF0724800);the CAMS Initiative for Innovative Medicine of China(grant no.2021-I2M-1-035);the Sector Fund(2060302);Young Elite Scientists Sponsorship Program by CAST(YESS)(grant no:2020QNRC001)。
Dear Editor,The case fatality rate of early SARS-CoV-2 infection is 3%(Ghebreyesus,2020),and the severe case rate is 24.3%(Sun et al.,2020).From the prototypic SARS-CoV-2 strain to the emergence of Alpha,Beta,and Delt...
关键词：NLRP3 branching ALPHA 
A novel chorismate mutase effector secreted from root-knot nematode Meloidogyne enterolobii manipulates plant immunity to promote parasitism
《Journal of Integrative Agriculture》2024年第12期4107-4119,共13页Tuizi Feng Yuan Chen Zhourong Li Ji Pei Deliang Peng Huan Peng Haibo Long 
supported by the Hainan Provincial Natural Science Foundation of China(323MS102 and 320QN307);Central Public-Interest Scientific Institution Basal Research Fund,China(1630042022008)。
Meloidogyne spp.is an economically important plant-parasitic nematode distributed worldwide.To fight with host immune system for successful parasitism,plant parasitic nematodes secrete effectors to promote infection.I...
关键词：Meloidogyne enterolobii EFFECTOR chorismate mutase salicylic acid plant immunity 
Integrated photothermal microcarriers for precise exosome-secreted microRNA profiling in breast cancer diagnosis
《Quantitative Biology》2024年第4期389-399,共11页Yunjie Shi Yun Cheng Peiyu Chen Lexiang Zhang Fangfu Ye 
National Key Research and Development Program of China,Grant/Award Number:2022YFA1405002;National Natural Science Foundation of China,Grant/Award Numbers:12325405,22307098;Wenzhou Institute,University of Chinese Academy of Sciences,Grant/Award Number:WIUCASQD2021012;Wenzhou high‐level innovation team;Development and application team of functional liv;Key Projects of Wenzhou Science and Technology Bureau,Grant/Award Number:ZG2023013;Wenzhou Basic Research Projects,Grant/Award Number:Y2023147;Zhejiang Provincial Natural Science Foundation of China,Grant/Award Number:LGF22C100003;Key Laboratory of Structural Malformations in Children of Zhejiang Province,Grant/Award Number:ZJET2301Z。
Breast cancer constitutes a significant global health burden,while conventional diagnosis approaches may lack precision and can be discomforting for patients.Exosomes have emerged as promising biomarkers for breast ca...
关键词：breast cancer digital PCR EXOSOMES MICRORNA PHOTOTHERMAL 
RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration被引量：4
《Neural Regeneration Research》2024年第8期1812-1821,共10页Xinyang Zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi 
supported by the National Natural Science Foundation of China,No.81870975(to SZ)。
Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported t...
关键词：ceRNA network EXOSOMES fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells 
Insight into Function and Subcellular Localization of a Type III-Secreted Effector in Pseudomonas syringae pv. tomato DC3000
《American Journal of Plant Sciences》2024年第10期835-846,共12页Jianzhong Huang Kai Chen Zhuojun Li Hongbin Zhang Xiuying Guan Xiaoju Zhong Peng Jia 
Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) is a bacterial pathogen of tomato and of the model plants Arabidopsis and Nicotiana benthamiana (N. benthamiana). Like numerous Gram-negative bacterial pathogens of ...
关键词：Cell Death HopAA1-1 Nicotiana benthamiana Pst DC3000 
Secreted Frizzled-Related Protein 5 Mediates Wnt5a Expression in Microcystin-Leucine-Arginine-Induced Liver Lipid Metabolism Disorder in Mice
《Biomedical and Environmental Sciences》2024年第8期850-864,共15页Meiyan Yang Furong Yu Qianqian Ji Huiying Zhang Jiaxiang Zhang Daojun Chen 
supported by the Natural Science Research Project of colleges and Universities in Anhui Province[2022AH052336];High Level Talent Research Initiation Fund Of Anhui Medical College[2023RC004]。
Objective Microcystin-leucine-arginine(MC-LR)exposure induces lipid metabolism disorders in the liver.Secreted frizzled-related protein 5(SFRP5)is a natural antagonist of winglesstype MMTV integration site family,memb...
关键词：Jun N-terminal kinase Secreted frizzled-related protein 5 WNT5A Hepatic lipid metabolism disorder 
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
《Protein & Cell》2024年第6期419-440,共22页Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu Yi-Zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu 
supported by National Key Research and Development Program of China(2023YFC2506400,2020YFA0112300);National Natural Science Foundation of China(Grant Nos.82230103,81930075,82073267,82203399,82072903);“Ten Thousand Plan”—National High-Level Talents Special Support Plan WR-YK5202101;Program of Shanghai Academic/Technology Research Leader 20XD1400700;Program for Outstanding Medical Academic Leader in Shanghai(2019LJ04);The innovative research team of high-level local university in Shanghai;The Fudan University Research Foundation(IDH 1340042);The Research Foundation of the Fudan University Shanghai Cancer Center(YJRC1603);Shanghai Anticancer Association EYAS PROJECT(SACA-CY23B07);The Natural Science Foundation of Hunan Province(2020JJ4916).
Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant progression.However,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail.Here,we ...
关键词：NOD1 breast chemotherapy 
Gastric cancer secreted miR 214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells被引量：4
《Oncology Research》2024年第3期489-502,共14页WEIXUE WANG TONGTONG WANG YAN ZHANG TING DENG HAIYANG ZHANG YI BA 
grants from the National Science Foundation of China(Nos.82173125,81974374,82072664,82103677);Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-009A);The Science&Technology Development Fund of Tianjin Education Commission for Higher Education(2020KJ127).
Diferent from necrosis,apoptosis,autophagy and other forms of cell death,ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated ftty acids under the action of iron divalent or lipoxygenase,lea...
关键词：Cellular ferroptosis EXOSOME Tyrosine kinase inhibitor Gastrointestinal tumors miRNA 
Elucidating the network interactions between 21 secreted Mycobacterium tuberculosis proteins and host proteins:the role of DnaK in enhancing Mtb survival via LDHB
《Acta Biochimica et Biophysica Sinica》2024年第5期819-823,共5页Hong Chen Xiang He He-Wei Jiang Yun-Xiao Zheng Hai-Nan Zhang Fan-Lin Wu Zhao-Wei Xu Shu-Juan Guo Sheng-Ce Tao 
partially supported by the grants from the Fourteenth Five-Year National Key Research and Development Program of China(No.2023YFC2307200);the R&D Program of Guangzhou National Laboratory(No.GZNL2023A01005);the Natural Science Foundation of China(No.92374110).
Among infectious diseases,Mycobacterium tuberculosis(Mtb)infection remains the world's leading cause of death,at~1.5 million in 2022.Approximately one-quarter of the global population is infected with Mtb,with more th...
关键词：MTB TUBERCULOSIS DATING 
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