supported by the National Natural Science Foundation of China(No.81971105);the Science and Technology Department of Jilin Province(No.YDZJ202201ZYTS677);the Norman Bethune Health Science Center of Jilin University(No.2022JBGS03);Science and Technology Department of Jilin Province(Nos.YDZJ202302CXJD061 and 20220303002SF);Jilin Provincial Key Laboratory(No.YDZJ202302CXJD017).
Neurological diseases are a major health concern,and brain injury is a typical pathological process in various neurological disorders.Different biomarkers in the blood or the cerebrospinal fluid are associated with sp...
supported by grants from the National Natural Science Foundation of China(Nos.82030037,81801288,and 81871009);STI2030-Major Projects(No.2021ZD0201801);the Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(No.11000022T000000444685)
To the Editor:Recent studies have characterized drugresistant epilepsy(DRE)as essentially a neural network disease.[1]Detection and disconnection of this pathological epileptic connectome or network can greatly improv...
Background: Epilepsy accounts for a significant portion of the global disease burden. However, little is known about the disease burden of epilepsy in China and its provinces. Methods: We assessed the burden of epilep...
To the Editor:Hemimasticatory spasm(HMS)is a relatively rare type of unilateral trigeminal nerve(TN)motor branch dysfunction,whose pathogenesis is currently unknown.The clinical manifestations of HMS are involuntary p...
National Nature Science Foundation of China(Nos.81671104,81701268,61761166004,and 81830033);Beijing Municipal Administration of Hospitals’Ascent Plan(No.DFL20150503);Capital Health Research and Development of Special(No.2018-2-1076);China Postdoctoral Science Foundation(No.2018T110120)。
Background:Anterior thalamic nuclei(ATN)deep brain stimulation(DBS)is an effective method of controlling epilepsy,especially temporal lobe epilepsy.Mossy fiber sprouting(MFS)plays an indispensable role in the pathogen...
supported by grants from the Beijing Natural Science Foundation(No.L182015);the Beijing Hospitals Authority’s Ascent Plan(No.DFL20190801)。
Background:Patients with temporal lobe epilepsy(TLE)originating from different seizure onset zones had distinct electrophysiological characteristics and surgical outcomes.In this study,we aimed to investigate the rela...
This work was supported by the grants from the National Key Research and Development Program of China(Nos.2016YFC0905100 and 2016YFC1000504);the CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2016-I2M-1-002);Beijing Municipal Science&Technology Commission(No.Z171100000417020).
Background:Benign epilepsy with centrotemporal spikes(BECTS)is the most common type of childhood idiopathic focal epilepsy.BECTS is associated with pervasive cognitive deficits and behavior problems.While seizures can...
A 50-year-old Chinese woman who experienced intermittent fever with xerostomia and xerophthalmia for 24 years,paroxysmal loss of consciousness for 11 years,aggravation for 1 year was admitted to the Peking University ...
Background:Epilepsy is a chronic and severe neurological disorder.Phosphatase and tensin homolog deleted on chromosome ten(PTEN)-deficient mice exhibit learning and memory deficits and spontaneous epilepsy.The aim of ...
To the Editor:Mutations in mitochondrial DNA(mtDNA)cause mitochondrial diseases with multisystem involvement and variable clinical phenotypes.Myoclonic epilepsy with ragged red fiber(MERRF)syndrome is characterized by...