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HOMEOSTASIS: 作品数：942被引量：3744H指数：25; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：祁红金正均陈红专朱戈李洋更多>>; 相关机构：军事医学科学院中国科学院上海第二医科大学首都医科大学附属北京口腔医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>

Fine-tuning protein hunger: sex- and mating-dependent setpoint control: 《Cell Research》2025年第3期161-162,共2页Yangkyun Oh Won-Jae Lee; While a balanced intake of macronutrients—carbohydrates,fats,and proteins—is essential for metabolic homeostasis,animals need higher protein intake during critical life stages like pregnancy.A recent paper in Cell b...; 关键词：mating dependent setpoint g protein coupled receptor pregnancy metabolic homeostasis fruit fly protein hunger macronutrient intake adjusting protein

Body–brain axis:orchestrating immune responses: 《Cell Research》2024年第11期757-758,共2页Leon Hosang Alexander Flügel Francesca Odoardi; In a recent article published in Nature,Jin and colleagues investigate the role of the body–brain axis in modulating peripheral immune responses.They demonstrate that this axis,which integrates peripheral immune sign...; 关键词：HOMEOSTASIS IMMUNE VAGUS

ILC2s govern sex-differential immunity in skin: 《Cell Research》2024年第9期605-606,共2页Katie L.Flanagan; The mechanisms driving sex differences in immunity are poorly understood and likely vary by body site;thus Chi et al.investigated the mechanistic basis of sex differences in tissue-specific immunity in a recent paper ...; 关键词：IMMUNITY HOMEOSTASIS

Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1: 《Cell Research》2024年第8期590-593,共4页Tianxin Wang Wenqin Tang Xiaolei Zhu Zhenyu Lv Jiayan Chen Yongze Li Xiaoyu Sun Haoyu Lv Quanchang Gu Fahui Li Jiangyun Wang; support from the National Natural Science Foundation of China(22121003,22337006,32027901 and 21927814);the National Key R&D Program of China(2019YFA0904201,2023YFA0916300,2021YFA0910202 and 2022YFA1304701);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37040203);the CAS Project for Young Scientists in Basic Research(YSBR-015 and YSBR-072-6).; Dear Editor,Succinate(SA)is a classic intermediate metabolite of the TCA cycle and is produced in mitochondria under normal physiological conditions.1 SA accumulates within cells and is secreted into the extracellular...; 关键词：CR1 HOMEOSTASIS INFLAMMATION

MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis: 《Cell Research》2024年第7期477-478,共2页Manuel Beltrán-Visiedo Siddharth Balachandran Lorenzo Galluzzi; Recent data from Cho et al.demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleosomes to license type I interferon secretion upon oncogenic stress and ionizing radiation.MRE11-mediated CGAS activati...; 关键词：INTERFERON HOMEOSTASIS ENDOGENOUS

Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection: 《Cell Research》2024年第6期403-404,共2页Hergen Spits Jenny Mjösberg; Group 2 innate lymphoid cells(ILC2s),known for their role in defending against parasites and regulating tissue homeostasis through cytokine secretion,were found to have a new function.Research in Cell shows that,when ...; 关键词：function. HOMEOSTASIS DEATH

B cell-reactive triad of B cells,follicular helper and regulatory T cells at homeostasis被引量：2: 《Cell Research》2024年第4期295-308,共14页Yihan Lin Zurong Wan Bo Liu Jiacheng Yao Tianqi Li Fang Yang Jianhua Sui Yongshan Zhao Wanli Liu Xuyu Zhou Jianbin Wang Hai Qi; funded in part by the National Key R&D Program of China(Ministry of Science and Technology,2018YFE0200300 to H.Q.);the National Natural Science Foundation of China(32130037,81621002 to H.Q.);the Natural Science Foundation of Beijing(grant 5224040 to B.L.).; Autoreactive B cells are silenced through receptor editing,clonal deletion and anergy induction.Additional autoreactive B cells are ignorant because of physical segregation from their cognate autoantigen.Unexpectedly,...; 关键词：HOMEOSTASIS markedly CENTERS

TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis被引量：1: 《Cell Research》2024年第3期258-261,共4页Yang Wang Meimei Huang Xiangyue Mu Wanlu Song Qing Guo Min Zhang Yuan Liu Ye-Guang Chen Liang Ge; funded by Ministry of Science and Technology of the People's Republic of China (2021YFA0804802);the National Natural Science Foundation of China (32225013,31988101 (Y.-G.C.),92254302,32130023,32061143009);Beijing Natural Science Foundation (Q20028);Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University (2022Z82WKJ009);Ministry of Science and Technology of the People's Republic of China (2019YFA0508602);New Cornerstone Science Foundation (Xplorer Prize).; Dear Editor,Unconventional protein secretion(UcPS)refers to the release of non-signal peptide-containing secretory proteins independent of the ER–Golgi trafficking.1 Although two major pathways including vesicle-depe...; 关键词：HOMEOSTASIS EPITHELIUM DETAILS

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease被引量：11: 《Cell Research》2024年第2期101-123,共23页Mengrui Wu Shali Wu Wei Chen Yi-Ping Li; supported by the National Institutes of Health(AR-070135 and AG-056438 to W.C.,and AR075735,DE023813,and DE028264 to Y.P.L);the National Natural Science Foundation of China(81900806 and 32070814 to M.W);the Qizhen Grant of Zhejiang University(226-2022-00132 to M.W.).; Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation,...; 关键词：HOMEOSTASIS CARTILAGE PRECISE

Structural basis of Sphingosine-1-phosphate transport via human SPNS2: 《Cell Research》2024年第2期177-180,共4页Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He; supported by the Startup Funds of HIT Center for Life Sciences;the National Natural Science Foundation of China(32070048 to Y.H.);Tsinghua University Initiative Scientific Research Program to Y.X.;We thank Dr.Zhiwei Huang of the HIT Center for Life Sciences for suggestion and support of this project,and Singapore Ministry of Health’s National ResearchOFIRG/OFIRG/0066/20;Ministry of Education MOE2018-T2-1-126,NUHSRO/2022/067/T1,and T2EP30123-0014(to L.N.N.).; Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Nota...; 关键词：HOMEOSTASIS TRANSPORT SINE

HOMEOSTASIS