Background: Gemcitabine is a deoxycytidine analog, which is used as first-line agent for pancreatic cancer therapy, and its efficacy relied on its intracellular conversion to active triphosphate form. However, adminis...
Objective To investigate the expression of SOCS3 and Pyk2 and their correlations in non-small cell lung cancer (NSCLC). Methods The expression of SOCS3 and Pyk2 was detected in 100 cases of NSCLC,human bronchial epith...
2008296 Effect of DNA methyltransferase 5-aza-2′-deoxycytidine on proliferation of human esophageal squamous cancer cell line Eca109 in vitro. YANG Ting(杨婷), et al. Med Res Center, 1st Affili Hosp, Xinjiang Med Un...
Projected supported by the Education Committee of Zhejiang Province; China (No20030584).
AIM: To establish a high pressure liquid chromatography (HPLC) method for determination of the concentration of gemcitabine (dFdC) and its metabolite(dFdU) in human plasma. METHODS: Plasma 1.0 mL spikedwith floxuridi...
Utilization of gene therapy approaches for cancertreatment requires either that the transferred genegains access to the great majority of the tumor cells orthat gene transfer results in a cytotoxic effect that willkil...
Nucleolar organizer regions (NORs) are places where transcription of rRNA genes takes place within a cell In situ DNA/RNA hybridization studies have shown that the genes, a variety of mammalian species, e.g., human, m...