IDEBENONE

作品数：8被引量：4H指数：1
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相关领域：医药卫生理学更多>>
相关作者：余斌张凯瑞江骥谢宏红胡蓓更多>>
相关机构：南方医科大学南方医院中国医学科学院北京协和医学院中国协和医科大学郑州大学更多>>
相关期刊：《质谱学报》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
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Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria
《Acta Pharmaceutica Sinica B》2024年第12期5435-5450,共16页Yi Wang Nahui Liu Lifan Hu Jingsong Yang Mengmeng Han Tianjiao Zhou Lei Xing Hulin Jiang 
supported by the National Natural Science Foundation of China(82020108029,82304416,82073398,82302367,China);supported by the Natural Science Foundation of Jiangsu Province(BK20231016,BK20231019,China);the China Postdoctoral Science Foundation(grant Number:2022M720173,China);Jiangsu Funding Program for Excellent Postdoctoral Talent(2023,China);the Fundamental Research Funds for the Central Universities(2632023GR20,China);State Key Laboratory of Natural Medicines China Pharmaceutical University(SKLNMZZ202021,China);Double First-class University Projects(CPU2018GY06,China);Double First-Rate construction plan of China Pharmaceutical University(CPU2022QZ18,China)。
Leber’s hereditary optic neuropathy(LHON)is an ocular mitochondrial disease that involves the impairment of mitochondrial complex I,which is an important contributor to blindness among young adults across the globe.H...
关键词：Engineered mitochondria Mitochondrial transfer Mitochondrial disease Leber’s hereditary optic neuropathy Nanoparticle Complex I defect Mitochondrial function IDEBENONE 
Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis被引量：2
《Acta Pharmaceutica Sinica B》2024年第6期2581-2597,共17页Hongliang Qiu Sihui Huang Yuting Liu Libo Liu Fengming Guo Yingying Guo Dan Li Xianfeng Cen Yajie Chen Meng Zhang Yan Che Man Xu Qizhu Tang 
supported by the following grants:the Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China(No.U22A20269);the National Key R&D Program of China(No.2018YFC1311300);the National Natural Science Foundation of China(Nos.82200262 and 82000229).
Doxorubicin(DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients,but related pharmacotherapeutic measures are relatively limited.Ferroptosis was recently identified as a major mechanism of DOX-in...
关键词：IDEBENONE DOX-induced cardiotoxicity Ferroptosis FSP1 UBIQUITINATION Lipid peroxidation Iron overload Clinical translation 
Therapeutic effects of Naohuan Dan combined with idebenone in treating mild cognitive impairment with kidney deficiency and phlegm stasis: A retrospective study
《Science of Traditional Chinese Medicine》2023年第2期115-122,共8页Jiaxi Ye Min Zhu Shengnuo Fan Qihui Huang 
This work was supported by the Natural Science Foundation of Guangdong,China(2019A1515011414 and 2023A1515011136);the Traditional Chinese Medicine Bureau of Guangdong Province,China(20211072).
Background:Naohuan Dan is a prescription used to treat dementia.This study aims to assess the effectiveness and safety of Naohuan Dan combined with idebenone in treating mild cognitive impairment(MCI)with kidney defic...
关键词：Mild cognitive impairment Observational study Naohuan Dan IDEBENONE Integrative Chinese and Western medicine 
Idebenone Maintains Survival of Mutant Myocilin Cells by Inhibiting Apoptosis
《Chinese Medical Journal》2016年第16期2001-2004,共4页Yue Guan Juan Li Tao Zhan Jian-Wen Wang Jian-Bo Yu Lan Yang 
The work was supported by a grant from Project of Science Foundation of Mudanjiang （No. G2012s0028）.
INTRODUCTION Glaucoma is a chronic progressive neurodegenerative disease and exhibits heterogeneity, polygenic inheritance, and incomplete penetrance. Primary open-angle glaucoma （POAG） is the most common form of gl...
关键词：APOPTOSIS CHOP GLAUCOMA ldebenone MYOCILIN 
Dietary supplementation of some antioxidants against hypoxia
《World Journal of Gastroenterology》2012年第44期6379-6386,共8页Sanaa Ahmed Ali Hanan Farouk Aly Lilla Mohammed Faddah Zeenat F Zaidi 
The present study aims to clarify the protective effect of supplementation with some antioxidants,such as idebenone(200 mg/kg,ip),melatonin(10 mg/kg,ip) and arginine(200 mg/kg,ip) and their combination,on liver functi...
关键词：HYPOXIA IDEBENONE MELATONIN Nitrate/ni-trite Adenosine triphosphate 
Determination of idebenone in plasma by HPLC/MS被引量：1
《Acta Pharmacologica Sinica》2000年第4期306-308,共3页胡蓓 江骥 谢宏红 
AIM: To develop a sensitive method for the analysis of idebenone [ Ide, 6- (10-hydroxydecyl) -2, 3-dimethoxy-5-methyl-p-benzoquinone] in human plasma. METHODS : The concentrations in plasma were determined by a high p...
关键词：IDEBENONE PHARMACOKINETICS high pressure liquid chromatography mass spectrum analysis clinical pharmacology BENZOQUINONES 
用快原子轰击质谱法研究醌式化合物─Idebenone被引量：1
《质谱学报》1995年第3期69-71,共3页余志立 
Ｉｄｅｂｅｎｏｎｅ是１种１，４－苯醌类化合物，其快原子轰击法质谱（ＦＡＢＭＳ）在不同的底物中，准分子离子是不同的。在底物甘油、硫代甘油和三乙醇胺中，准分子离子为（Ｍ＋２Ｈ）￣＋，而在底物３－硝基苯甲醇中，准分子离子为...
关键词：IDEBENONE 苯醌 FABMS 质谱 
Idebenone和bifemelane的向精神作用比较(日)
《精神医学杂志》1993年第1期44-44,共1页伊茂森 
过去,我们应用定量脑电图学方法,通过脑电图变化来判断药物对脑功能的影响,并探索在临床上与精神效果的关系。这次我们把代表性脑代谢赋活剂Idebenone(IDB)和Bifemelane(BFM)应用于健康成人志愿者和脑血管性痴呆患者,用定量脑电图学方法...
关键词：脑电图学 脑血管性痴呆 IDEBENONE bifemelane 脑代谢 脑功能 精神作用 中枢作用 长谷川 简易智能量表 
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