Supported by the National Natural Science Foundation of China(Study of the Role and Mechanism of PDZK1 Protein in the Downregulation of Mrp2 by Estrogen in Cholestasis,No.81503146 and Study of the Choleretic Effect of Calculus Bovis Sativus Based on PDZK1 Protein Interaction Networks and Bile Acid Metabolic Profile,No.81573788);Science Foundations of Health and Family Planning Commission of Wuhan Municipality(No.WZ15Z02)
OBJECTIVE:To investigate the pathway through which Calculus Bovis Sativus (CBS) up-regulates hepatic multidrug resistance-associated protein 2 (Mrp2) and Mrp4 in 17α-ethynylestradiol (EE)-induced cholestasis.METHODS:...
supported by the grant from Sasaki Environment Technology Foundation to T.Tanaka
Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estroge...
the grant from Tianjin Nature Science Fund Key Item(No.043802411)
Objective: To study the anti-tumor activities of novel estrogen compound 17a α-D-homo-ethynylestradiol-3-acetate in vitro and in vivo. Methods: In vitro anti-tumor activity was assayed in adenoma cells A549 and hum...
Project supported by the Guangdong Natural Science Founda-tion; No 020554.
AIM: To investigate the skeletal effects of total tanshinone in ovariectomized rats by analyzing cancellous bonehistomorphometry of fourth lumbar vertebrae (LV4) and proximal tibial metaphyses (PTM). METHODS: Four-mo...