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作品数:166被引量:658H指数:12
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相关作者:郑世曦蒋建新朱佩芳杨清武王正国更多>>
相关机构:中国科学院华中科技大学海南医学院附属医院第三军医大学大坪医院更多>>
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Up-regulation of circular RNA hsa_circ_01844 induces apoptosis and suppresses proliferation and migration of glioblastoma cells
《Chinese Medical Journal》2021年第1期81-87,共7页Jin-Xu Zhou Ke-Fei Chen Shuai Hu Ji-Rong Dong Hong-Xiang Wang Xin Su Yu-Hai Wang Jun-Sheng Chu 
Background:Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers,such as liver cancer,lung cancer,breast cancer,and others.The potential role of circular ...
关键词:GLIOBLASTOMA Hsa_circ_01844 APOPTOSIS PROLIFERATION MIGRATION 
Aberrant Alternative Polyadenylation is Responsible for Survivin Up-regulation in Ovarian Cancer被引量:5
《Chinese Medical Journal》2016年第10期1140-1146,共7页Xiang-Jun He Qi Zhang Li-Ping Ma Na Li Xiao-Hong Chang Yu-Jun Zhang 
Background: Survivin is an oncoprotein silenced in normal mature tissues but reactivated in serous ovarian cancer (SOC). Although transcriptional activation is assumed for its overexpression, the long 3'-untransla...
关键词:3'-Untranslated Region Shortening Alternative Polyadenylation MICRORNA Serous Ovarian Cancer SURVIVIN 
Up-regulation of TIMP-2 expression promotes SHI-1 leukemic cells proliferation and infiltration in immunodeficiency mice被引量:1
《Chinese Medical Journal》2014年第24期4243-4249,共7页Li Zhenjiang Chen Zixing Cen Jiannong He Jun Qiu Qiaocheng Xue Yongquan 
This work was supported by the Grant from National Natural Science Foundation of China (No. 30670905).
Background MMPs and TIMPs play important roles in tumor angiogenesis and invasion. Studies have shown that TIMP- 2 has two roles in tumor invasion. However, its role in leukemic infiltration has not been well investig...
关键词:acute monocytic leukemia extramedullary infiltration TIMP-2 nude mice model 
Up-regulation of Ras/Raf/ERK1/2 signaling in the spinal cord impairs neural cell migration, neurogenesis, synapse formation, and dendritic spine development被引量:8
《Chinese Medical Journal》2013年第20期3879-3885,共7页Cao Fu-jiang Zhang Xu Liu Tao Li Xia-wen Malik, Mazar Feng Shi-qing 
Background The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promo...
关键词:Ras/Raf/ERK1/2 spinal cord injury  neural circuit imbalances  signaling pathway 
Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration被引量:11
《Chinese Medical Journal》2013年第4期640-645,共6页SHI Yu-long MIAO Rui-zheng CHENG Li GUO Xiao-bo YANG Bo JING Chang-qing ZHANG Li JINXing LI Le-ping 
This study was supported by a grant from the Natural Science Foundation of Shandong Province of China (Nos. ZR2011HM041, Y2007C102, ZR2011HM076), Key Research Project from Shandong Science and Technology Commission (Nos. 2011GGH21844, 2007H2071), and the the National Youthful Science Foundation of China (No. 81101858).
Background T-lymphoma and metastasis gene 1 (Tiaml) produces a guanine nucleotide exchange factor (GNEF) that regulates guanosine triphosphatase, which transforms guanosine diphosphate to guanosine triphosphate. R...
关键词:T-lymphoma and metastasis gene 1 gastric cancer metastasis gene expression survival 
Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations被引量:11
《Chinese Medical Journal》2012年第5期874-881,共8页HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua 
This study was partially supported by grants from the National Natural Science Foundation of China (No. 30270636 and 30671015).
Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unk...
关键词:thyroid dysfunction ADIPOCYTOKINES thyroid hormone 3T3-L1 cells 
Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features被引量:19
《Chinese Medical Journal》2010年第16期2215-2220,共6页SU Yan-jun XU Feng YU Jin-pu YUE Dong-sheng REN Xiu-bao WANG Chang-li 
Background S100A8 and S100A9 are two members of the S100 protein family characterized by the presence of two Ca2+-binding sites of the EF-hand type.Previous studies suggested that the whole S100 family displays signi...
关键词:S100A8 S100A9 INFLAMMATION lung adenocarcinoma 
Up-regulation of the transient A-type K^+ current (IA) in the differentiation of neural stem cells of the early postnatal rat hippocampus被引量:1
《Chinese Medical Journal》2010年第13期1731-1735,共5页GUO Hong-bo HUANG Lian-yan ZOU Yu-xi ZOU Fei 
This work was supported in part by grants from National Natural Science Foundation of China (No. 30971183), Guangdong Natural Science Foundation (No. 7005213), and Science and Technology Projects in Guangdong Province (No. 2009B030801230).
Background Neural stem cells (NSCs) not only are essential to cell replacement therapy and transplantation in clinical settings, but also provide a unique model for the research into neurogenesis and epigenesis. How...
关键词:stem cells transient A-type K^+ currents cell differentiation HIPPOCAMPUS patch-clamp techniques 
Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin ll-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts被引量:7
《Chinese Medical Journal》2006年第13期1094-1102,共9页WANG Xiao-dan CHEN Xiang-mei WANG Jian-zhong HONG Quan FENG Zhe FU Bo ZHOU Feng WANG Feng-yang FAN Dai-ming 
This work was supported by grants from the Creative Research Group Fund of the Natural Science Foundation of China (No.30121005) the National Science Foundation of China (No.30370559) the Medical Health Research Fund of People's Liberation Army of China (No. 04T6003) the Major Basic Project of China (973) (No.G2000057000).
Backgroud Angiotensin Ⅱ (Ang Ⅱ), a principal effector of renin-angiotensin system (RAS) and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ (AT1) an...
关键词:STAT3 protein  human tissue inhibitor of metalloproteinase-1 angiotensin  aging FIBROBLASTS 
Up-regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line被引量:5
《Chinese Medical Journal》2005年第22期1900-1906,共7页LU Chao ZHAO Feng-di LI Xiao-bo YIN Lian-hua 
This study was supported by grants from National Natural ScienceFoundation of China(No.30470689), and the Science DevelopingFoundation of Shanghai Medical Healthy Bureau (No.034087)
Background Protease activated receptor-2 is cleaved and activated by trypsin or mast cell tryptase and may play an important role in inflammation. However, it is unknown whetehr PAR-2 can mediate tryptase-induced infl...
关键词:tryptase·protease activated receptor-2·interleukin-8 
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