Background:Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers,such as liver cancer,lung cancer,breast cancer,and others.The potential role of circular ...
Background: Survivin is an oncoprotein silenced in normal mature tissues but reactivated in serous ovarian cancer (SOC). Although transcriptional activation is assumed for its overexpression, the long 3'-untransla...
This work was supported by the Grant from National Natural Science Foundation of China (No. 30670905).
Background MMPs and TIMPs play important roles in tumor angiogenesis and invasion. Studies have shown that TIMP- 2 has two roles in tumor invasion. However, its role in leukemic infiltration has not been well investig...
Background The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promo...
This study was supported by a grant from the Natural Science Foundation of Shandong Province of China (Nos. ZR2011HM041, Y2007C102, ZR2011HM076), Key Research Project from Shandong Science and Technology Commission (Nos. 2011GGH21844, 2007H2071), and the the National Youthful Science Foundation of China (No. 81101858).
Background T-lymphoma and metastasis gene 1 (Tiaml) produces a guanine nucleotide exchange factor (GNEF) that regulates guanosine triphosphatase, which transforms guanosine diphosphate to guanosine triphosphate. R...
This study was partially supported by grants from the National Natural Science Foundation of China (No. 30270636 and 30671015).
Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unk...
Background S100A8 and S100A9 are two members of the S100 protein family characterized by the presence of two Ca2+-binding sites of the EF-hand type.Previous studies suggested that the whole S100 family displays signi...
This work was supported in part by grants from National Natural Science Foundation of China (No. 30971183), Guangdong Natural Science Foundation (No. 7005213), and Science and Technology Projects in Guangdong Province (No. 2009B030801230).
Background Neural stem cells (NSCs) not only are essential to cell replacement therapy and transplantation in clinical settings, but also provide a unique model for the research into neurogenesis and epigenesis. How...
This work was supported by grants from the Creative Research Group Fund of the Natural Science Foundation of China (No.30121005) the National Science Foundation of China (No.30370559) the Medical Health Research Fund of People's Liberation Army of China (No. 04T6003) the Major Basic Project of China (973) (No.G2000057000).
Backgroud Angiotensin Ⅱ (Ang Ⅱ), a principal effector of renin-angiotensin system (RAS) and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ (AT1) an...
This study was supported by grants from National Natural ScienceFoundation of China(No.30470689), and the Science DevelopingFoundation of Shanghai Medical Healthy Bureau (No.034087)
Background Protease activated receptor-2 is cleaved and activated by trypsin or mast cell tryptase and may play an important role in inflammation. However, it is unknown whetehr PAR-2 can mediate tryptase-induced infl...