HIGH-AFFINITY

作品数：32被引量：111H指数：7
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相关机构：浙江大学南昌大学更多>>
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An innovative indirect competitive immunosorbent approach for precise detetion aflatoxin B_(1) based on high-affinity immunoglobulin G coupled CuO-anchored Fe_(3)O_(4)nanozymes
《Food Science and Human Wellness》2025年第3期1017-1025,共9页Xueqin Wang Chuan Liu Haizhen Tao Xuanping Zhao Mengna Wan Junyan Liu Na Li 
supported by the Scientific and Technological Project of Henan Province(232102321117);National Natural Science Foundation of China(82202198);the National Engineering Research Center of Wheat and Corn Further Processing of Henan University of Technology(NL2022010);Project of Basic Research Fund of Henan Provincial Institute of Medical and Pharmacological Sciences(2023BP0106);the Innovative Funds Plan of Henan University of Technology(2020ZKCJ23)。
Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive imm...
关键词：Aflatoxin B_(1) Enhanced peroxidase-mimic activities Nanozyme based enzyme-linked immunosorbent assay Food crops 
A High-Affinity Methyl-CpG-Binding Protein for Endonuclease-Free and Label-Free DNA Methyltransferase Activity Detection
《Journal of Analysis and Testing》2024年第3期327-334,共8页Yang Bai Shulin Tan Yingsong Sheng Yueqing Gu Haiping Wu Baicun Li Yunlong Liu 
funded by the National Natural Science Foundation of China(61901527,82300051);National Key Research and Development Program of China(2022YFF0710803,2022YFF0710800);Fundamental Research Funds for the Central Universities(2632021ZD02).
DNA methyltransferase(MTase)activity detection has received increasing attention as a promising biomarker and therapeutic target.However,most of these detection methods rely on endonuclease digestion and signal groups...
关键词：DNA methyltransferase Methyl-CpG-binding protein Surface plasmon resonance Inhibitor screening BIOSENSING 
Molecular recognition of cyclophanes in water
《Chinese Chemical Letters》2024年第5期32-44,共13页Fang-Yuan Chen Wen-Chao Geng Kang Cai Dong-Sheng Guo 
supported by the National Natural Science Foundation of China(Nos.22271164,U20A20259);the Fundamental Research Funds for the Central Universities;the NCC Fund(No.NCC2020FH04).
Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular chemistry.The mechanisms of molecular recognition in water is key to comprehending biological processe...
关键词：Biomimetic receptor CYCLOPHANE Molecular recognition Hydrophobic effect HIGH-AFFINITY Macrocycles 
Structures and ion transport mechanisms of plant high-affinity potassium transporters被引量：1
《Molecular Plant》2024年第3期409-422,共14页Jiangqin Wang Yanping Luo Fan Ye Zhong Jie Ding Shao Jian Zheng Shuai Qiao Yong Wang Jiangtao Guo Wei Yang Nannan Su 
supported in part by the National Key Research and Development Program of China(2022YFA1303400 to S.J.Z.and S.Q.,2020YFA0908501 to J.G.,and 2021YFF1200404 to Y.W.);the National Natural Science Foundation of China(32371204 to J.G.,82030108 and 31872796 to W.Y.,and 32371300 to Y.W.);Zhejiang Provincial Natural Science Foundation(LR19C050002 to J.G.);the China Postdoctoral Science Foundation(no.74,2023M743044 to J.W.);the National Postdoctoral Researcher Program of China(GZB20230634 to J.W.).
Plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt tolerance.In this study,we present cryoelectron microscopy s...
关键词：HKTs structure ion selectivity mechanism salt tolerance 
Characterization of folic acid,5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters:impact on pregnancy and development
《Reproductive and Developmental Medicine》2023年第2期102-107,共6页Ana M.Palacios Rachel A.Feiner Robert M.Cabrera 
supported by R01 HD100229-02.
Objectives:Folates are B vitamins that are essential for several molecular,cellular,and biological processes,including nucleotide synthesis,methylation,and methionine cycling.The physiological impacts of these process...
关键词：5-methyltetrahydrofolate folic acid folinic acid folate receptorα folate receptorβ AFFINITY 
Inhibitory effect of calcium phosphate-coated high-affinity liposomes on Staphylococcus aureus and its biofilms
《Food Bioscience》2022年第6期954-964,共11页Lin Lin Pin Zhang Changzhu Li Zichun Hua Haiying Cui 
financially supported by State Key Laboratory of Utilization of Woody Oil Resource(Grant no.2019XK 2002);National Natural Science Foundation of China(Grant no.31972172);Natural Science Foundation of Jiangsu Province(Grant no.BK20201417);Jiangsu Province Research Fund(Grant no.JNHB-131);Jiangsu University Research Fund(Grant no.11JDG050).
The contamination of Staphylococcus aureus(S.aureus)and its biofilm poses a serious challenge to food safety.In this study,a high-affinity liposome coated with calcium phosphate was developed to provide a novel strate...
关键词：Litsea cubeba essential oil Anionic liposomes Calcium phosphate Staphylococcus aureus ANTIBIOFILM 
New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq
《Virologica Sinica》2022年第5期758-761,共4页Mengyuan Chen Shuizhen He Hualong Xiong Dongxu Zhang Shaojuan Wang Wangheng Hou Xiaomei Zhu Jin Wang Yang Huang Congming Hong Yubin Wu Ruoyao Qi Tianying Zhang Quan Yuan Tingdong Li Yixin Chen Shiyin Zhang Shengxiang Ge Jun Zhang Ningshao Xia 
supported by the National Key R&D Program of China(grant number 2020YFC0842600);the National Natural Science Foundation of China (grant numbers 82041038 and 31730029)
Dear Editor,Theworld had suffered pandemics of COVID-19 caused by SARS-CoV-2.At the time ofwriting,COVID-19 is still widely spreading inmany countries and regions,and by June 14,2022,totally 532,887,351 cases,includin...
关键词：PHIP totally 
Key molecules of Mucorales for COVID-19-associated mucormycosis:a narrative review
《Journal of Bio-X Research》2022年第3期104-111,共8页Priyanka Baberwal Arjun Singh Abhinav Adarsh Yatender Kumar 
Mucormycosis is a lethal human disease caused by fungi of the order Mucorales.Mucormycosis is caused by fungi mainly belonging to the genera Mucor,Rhizopus,and Lichtheimia,all of which belong to the order Mucorales.Th...
关键词：ADP-ribosylation factor CALCINEURIN COVID-19-associated mucormycosis high-affinity iron permease spore coat protein 
A Practical and High-Affinity Fluorescent Probe for Butyrylcholinesterase:A Good Strategy for Binding Affinity Characterization
《Chinese Journal of Chemistry》2022年第11期1285-1292,I0002,共9页Lei Wang Chenxi Du Hui Liu Weimin Qiu Xin Lu Yanyu Hu Yueqing Li Tianyu Sun Yao Chen Haopeng Sun 
We gratefully thank the support from the grants of the National Natural Science Foundation of China(Nos.81872728 and 82173652);the Natural Science Foundation of Jiangsu Province(No.BK20191411)。
Butyrylcholinesterase(BChE)is regarded as a promising target for the treatment of Alzheimer's disease(AD),as its level significantly increases along with the progress of this disease.Therefore,the development of poten...
关键词：BUTYRYLCHOLINESTERASE Alzheimer's disease Fluorescent probes INHIBITORS High-throughput screening 
High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library被引量：1
《Engineering》2021年第11期1557-1565,共9页Hao Liu Chunxia Qiao Naijing Hu Zhihong Wang Jing Wang Jiannan Feng Beifen Shen Yuanfang Ma Longlong Luo 
This work was supported by grants from the National Natural Science Foundation of China(21976210).
Immunotherapy with anti-programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PDL1)monoclonal antibodies has become routine in the treatment of many kinds of human cancers,such as lung cancer,intestinal...
关键词：Decoy PD-1 PD-L1 Mammalian cell library Epitope-oriented 
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