MICROGLIOSIS

作品数：4被引量：17H指数：3
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Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
《Acta Pharmacologica Sinica》2025年第2期353-365,共13页Ya-nan Gao Kai-jun Pan Yong-mei Zhang Ying-bei Qi Wen-gang Chen Ting Zhou Hai-chao Zong Hao-ran Guo Jin-wen Zhao Xing-chen Liu Zi-tong Cao Ze Chen Tao Yin Yi Zang Jia Li 
founded by National Natural Science Foundation of China grant 82001572;National Natural Science Foundation of China grant 81971265;National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”grant 2018ZX09711002-007-002;Shanghai Commission of Science and Technology grant 2021000003;Shanghai Science and Technology Development Funds(Shanghai Commission of Science and Technology)grant 19JC1416300.
Depressive disorders are a global mental health challenge that is closely linked to inflammation,especially in the post-COVID-19 era.The JAK-STAT pathway,which is primarily associated with inflammatory responses,is no...
关键词：tofacitinib depression JAK-STAT pathway MICROGLIOSIS synaptic defects 
L-Norvaline, a new therapeutic agent against Alzheimer’s disease被引量：4
《Neural Regeneration Research》2019年第9期1562-1572,共11页Baruh Polis Kolluru D.Srikanth Vyacheslav Gurevich Hava Gil-Henn Abraham O.Samson 
supported by Marie Curie CIG Grant 322113;Leir Foundation Grant;Ginzburg Family Foundation Grant;Katz Foundation Grant(all to AOS)
Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease(AD).Upregulation of arginase was shown to contribute to neurodegeneration.Regulation of arginase activity appears ...
关键词：dementia ARGINASE inhibition ARGININE urea cycle MICROGLIOSIS NEUROINFLAMMATION cytokines tumor NECROSIS factor mTOR NEURODEGENERATION 
Neuroprotection by immunomodulatory agents in animal models of Parkinson's disease被引量：7
《Neural Regeneration Research》2018年第9期1493-1506,共14页Bridget Martinez Philip V.Peplow 
Parkinson’s disease（PD） is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons.The cell bodies of these neurons are pre...
关键词：Parkinson＇s disease immunomodulatory agents NEUROPROTECTION INFLAMMATION oxidative stress animal models MICROGLIOSIS ASTROGLIOSIS 
Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain被引量：6
《Neuroscience Bulletin》2012年第1期61-68,共8页Wen-Zhen Shi Chun-Zhen Zhao Bing Zhao Xiao-Liang Zheng San-Hua Fang Yun-Bi Lu Wei-Ping Zhang Zhong Chen Er-Qing Wei 
supported by the National Natural Science Foundation of China (81072618,30772561,30873053 and 30672449);the Natural Science Foundation of Zhejiang Province,China (Y2090069);the "Qian Jiang Ren Cai Research Plan" Zhejiang Province,China (2010R10055);Fundamental Research Funds for the Central Universities of China (2009QNA7008)
Objective To determine whether aquaporin-4 （AQP4） regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. Methods Brain cryoinjury was applied to AQP4 knocko...
关键词：AQUAPORIN-4 gene deficiency CRYOINJURY microglia ASTROCYTE 
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