ICARITIN

作品数：22被引量：100H指数：5
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相关领域：医药卫生更多>>
相关作者：郑敏翠旷文勇佟敬山李其辉李昱瑛更多>>
相关机构：中南大学湖南省儿童医院青岛大学吉林大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Chinese Herbal Medicines》《Medicinal Plant》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金更多>>
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Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation
《Acta Pharmaceutica Sinica B》2024年第9期3916-3930,共15页Zezhong Mou Yiling Chen Jinzhong Hu Yun Hu Lujia Zou Xinan Chen Shenghua Liu Qiuping Yin Jian Gong Shuchen Li Shanhua Mao Chenyang Xu Haowen Jiang 
grants from National Natural Science Foundation of China(No.82373222,No.82202970);Leading Talent Program by Shanghai Municipal Health Commission(2022LJ008,China);Shanghai Shenkang Hospital Development Center(SHDC12021104,China);Science and Technology Commission of Shanghai Municipality(22Y21900200&22YF1404300,China).
Tumor relapse and metastasis are the major causes of mortality associated with urothelial cancer.In the tumor microenvironment,negative regulatory molecules and various immune cell subtypes suppress antitumor immunity...
关键词：ICARITIN NEUTROPHIL Neutrophil extracellular trap PADI2 Urothelial cancer 
Enhancing osteogenic bioactivities of coaxial electrospinning nanoscaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration
《Nano Research》2024年第7期6430-6442,共13页Peng Wang Qianjin Wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai Wang Jiayu Gu Hao Wu Zhihong Xu Qing Jiang 
supported by the National Basic Research Program of China(Nos.2021YFA1201404,and 2019YFA0210103);the National Natural Science Foundation of China(Nos.32271413,and 82272492);Natural Science Foundation of Jiangsu Province(No.BK20232023);Science program of Jiangsu Province Administration for Market Regulation(No.KJ2024010).
Bone tissue engineering provides a promising strategy for the treatment of bone defects.Nonetheless,the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical strength and ab...
关键词：iron oxide nanoparticles ICARITIN coaxial electrospinning nano-scaffolds MEK/ERK signaling pathway bone regeneration 
Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature被引量：1
《World Journal of Clinical Cases》2024年第16期2847-2855,共9页Wen-Jie Song Jian Xu Ye Nie Wei-Min Li Jian-Ping Li Li Yang Meng-Qi Wei Kai-Shan Tao 
BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the firs...
关键词：Hepatocellular carcinoma ICARITIN Conversion DOWNSTAGING Portal vein thrombus Case report 
Nanomedicine-boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma被引量：2
《Military Medical Research》2023年第3期403-414,共12页Yi Lu Yue Gao Huan Yang Yong Hu Xin Li 
supported by the National Natural Science Foundation of China(52103181,81873196);the Sino-German Center for Research Promotion(GZ1505);the Fundamental Research Funds for the Central Universities(22120220075);the China Scholarship Council(201908320330)。
Traditional treatments for advanced hepatocellular carcinoma(HCC),such as surgical resection,transplantation,radiofrequency ablation,and chemotherapy are unsatisfactory,and therefore the exploration of powerful therap...
关键词：ICARITIN NANOMEDICINE Advanced hepatocellular carcinoma IMMUNOTHERAPY Clinical translation 
Icaritin enhances sorafenib-induced apoptosis through a mitochondria-dependent pathway被引量：1
《Journal of Chinese Pharmaceutical Sciences》2022年第12期928-937,共10页Axi Shi Tiantian Shen Wenbin Xia Lili Xi Lijun Wang Yuhui Wei 
Sorafenib remains the standard systemic treatment for advanced human hepatocellular carcinoma(HCC).However,the low response rate,high recurrence,and high progression limit the therapeutic efficacy.Therefore,a combinat...
关键词：SORAFENIB ICARITIN Human hepatocellular carcinoma 
Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli被引量：14
《Science Bulletin》2021年第18期1906-1916,M0004,共12页Pingping Wang Chaojing Li Xiaodong Li Wenjun Huang Yan Wang Jiali Wang Yanjun Zhang Xiaoman Yang Xing Yan Ying Wang Zhihua Zhou 
supported by the National Key Research and Development Program of China (2018YFA0900700);the National Natural Science Foundation of China (31901021 and 31921006);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB27020206);the International Partnership Program of Chinese Academy of Sciences (153D31KYSB20170121);the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences (KFJ-BRP-009)。
Icaritin is a prenylflavonoid present in the Chinese herbal medicinal plant Epimedium spp. and is under investigation in a phase Ⅲ clinical trial for advanced hepatocellular carcinoma. Here, we report the biosynthesi...
关键词：淫羊藿素 Ⅲ期临床试验 晚期肝癌 合成生物学 异戊烯基转移酶 人工合成 甲基转移酶 从头合成 
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK被引量：4
《Journal of Clinical and Translational Hepatology》2021年第3期373-383,共11页Yue Wu Ying Yang Fang Li Jie Zou Yu-Hao Wang Meng-Xia Xu Yong-Lun Wang Rui-Xi Li Yu-Ting Sun Shun Lu Yuan-Yuan Zhang Xiao-Dong Sun 
This work was financially supported by the National Natural Science Foundation of China(Grant No.81770580);open funding from the Sichuan Provincial Key Laboratory of Radiation Oncology(Grant No.2020FSZLX-02).
Background and Aims:Lipid accumulation is the major characteristic of non-alcoholic fatty liver disease,the prevalence of which continues to rise.We aimed to investigate the effects and mechanisms of icaritin on lipid...
关键词：ICARITIN Lipid accumulation NAFLD AMPK AUTOPHAGY 
Improved Synthesis of Icaritin and Total Synthesis of β-Anhydroicaritin被引量：1
《Chemical Research in Chinese Universities》2019年第4期616-620,共5页TONG Jie LIU Chang WANG Bo 
Supported by the National Natural Science Foundation of China(No.21672203).
Natural products icaritin and β-anhydroicaritin with P-glycoprotein(P-gp) inhibitory activities were ciently synthesized in nine steps from commercially available phloroglucinol. A modified Algar-Flynn-Oyamada cycliz...
关键词：ICARITIN FLAVONOL Regioselectivity Algar-Flynn-Oyamada 
Metabolic profiling of icaritin in rats using UHPLC-Q/TOF-MS被引量：1
《Chinese Herbal Medicines》2019年第2期185-191,共7页Tong Wang Xin-chi Feng Li-qin Ding Kun Wang Xu-liu Shi Li-wei Chai Yang Li Feng Qiu 
supported by the National Natural Science Foundation of China (NSFC) [No. 81430095]
Objective: To identify the in vivo metabolites of icaritin and speculate its metabolic profiling in rats.Methods: The plasma, bile, urine, and feces of rats were collected after orally administration of icaritin at a ...
关键词：ICARITIN METABOLITES Metabolynx RATS UHPLC/Q-TOF-MS/MS 
Protective effect of icaritin on focal cerebral ischemic–reperfusion mice被引量：2
《Chinese Herbal Medicines》2018年第1期40-45,共6页cheng-hong sun li-hong pan jian yang jing-chun yao bing-bing li yu-jun tan gui-min zhang ying sun 
financially supported by the Natural Foundation of Shandong Province (ZR2015QL002)
Objective： To investigate the protective effects of icaritin （ICT）, one of the active ingredients in Epimedii Folium, on mouse model of cerebral ischemia-reperfusion （I/R） in vivo. Methods： ICR mice were subject...
关键词：brain edema brain infarct ICARITIN focal cerebral ischemic-reperfusion NEUROINFLAMMATION oxidative damage 
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