This work was supported by Clinical Research Center,Shanghai Jiao Tong University School of Medicine(DLY201818);National Natural Science Foundation of China(81901832);Program of Science and Technology Innovation Plan in Shanghai(18411961200,19ZR1477800);Clinical Research Plan of SHDC(SHDC2020CR4066);Shanghai Key Laboratory of Psychotic Disorders(13DZ2260500);Shanghai Mental Health Center Foundation(2020-FX-01,2021zd01).
Initially,zolpidem,a non-benzodiazepine hypnotic agent,was considered to have fewer adverse reactions than traditional benzodiazepines.However,after zolpidem was approved for medical use,an increasing number of case r...
Zolpidem is a short-acting non-benzodiazepine hypnotic agent,commonly recommended for short-term treatment of insomnia.Zolpidem has less dependence potential than benzodiazepines.Patients with mental illnesses often h...
Insomnia and related sleep disorders (somnipathies) affect a large segment of the population, and result in a significant negative impact on quality of life and reduced or lost productivity. The speed of sleep onset i...
Zolpidem is a sedative-hypnotic drug used to treat in sleep disorders, and it is the most commonly prescribed drug for insomnia. It reduces sleep latency and increases total sleep time. However, some studies have repo...
Zolpidem, as an imidazopyridine agent, is a widely prescribed drug among practitioners for short-term treatment of insomnia. Nevertheless, there have been a number of cases associated with the adverse effects of the s...
Funds of the Chinese Army Medical Science and Technology Research"Eleventh Five-Year Plan"Project(Grant No.06G023)
In the present study, we aimed to investigate the effect of CYP3A4* 18 genotype on the pharmacokinetics of zolpidem in healthy Chinese Hui volunteers. Blood samples were collected from volunteers for CYP3A4 genotypin...
To examine the efficacy of the melatonin receptor agonist ramelteon for nocturia, it was compared with zolpidem, a conventional non-benzodiazepine hypnotic. A total of 50 patients with nocturia (32 urinations/night) w...
Aim: Zolpidem is a non-benzodiazepine agonist at benzodiazepine binding site in GABAA receptors, which is increasingly prescribed. Recent studies suggest that prolonged zolpidem treatment induces tolerance. The aim o...
Aim: The substantia nigra pars reticulata (SNr) constitutes one of the output centers of the basal ganglia, and its abnormal activity is believed to contribute to some basal ganglia motor disorders. Different lines...