云南高校图书馆联盟文献共享服务平台- INDOLIN-2-ONE

INDOLIN-2-ONE: 作品数：11被引量：2H指数：1; 导出分析报告; 相关领域：理学化学工程更多>>; 相关作者：丁盼盼张晶晶廖蓟史博颖许兴智更多>>; 相关机构：国家知识产权局北京大学首都师范大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》《Chemical Research in Chinese Universities》《有机化学》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>

Cascade reaction involving intramolecular oxygen-migration:Efficient synthesis of 3-allylidene-indolin-2-one compounds under metal-free conditions: 《Chinese Chemical Letters》2021年第1期433-436,共4页Rui-Ying Zhang Meng-Meng Xu Hai-Yan Li Xiao-Ping Xu Shun-Jun Ji; the National Natural Science Foundation of China(Nos.21772138 and 21672157);PAPD,the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX19_1899);the Project of Scientific and Technologic Infrastructute of Suzhou(No.SZS201708);State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials for financial support。; An efficient synthesis of 3-(diarylallylidene)oxindoles from 3-(1 H-indol-3-yl)-1,1-diarylpropan-1-ol under metal-free conditions is described.NBS serves as a critical medium leading to a facile oxygenmigration in the...; 关键词：NBS mediated Oxygen migration Conjugate double bonds Multi-step cascade

HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins: 《Chinese Chemical Letters》2020年第9期2465-2468,共4页Xiaohan Yuan Shuai Wang Jialing Cheng Bin Yu Hong-Min Liu; supported by the National Natural Science Foundation of China(Nos.81773562,81703326 and 81973177);The Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202005);China Postdoctoral Science Foundation(Nos.2018M630840 and 2019T120641)。; The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones(27 examples,up to 98% yield) from readily available indoles and isatin derivatives are d...; 关键词：INDOLES ISATINS HFIP Catalyst-free synthesis 3 3-Di(indoly)indolin-2-ones

Direct construction of 3',4'-dihydrospiro[pyrrol-3,2'-oxindoles]through a cascade Michael/cyclization reaction of 3-aminoindolin-2-ones with enones/enals: 《Chinese Chemical Letters》2015年第8期1050-1053,共4页Dao-Cai Wang Hang Song Chun-Yun Xu Hui Dong Jie Liu; Financial support for this work by the National Natural Science Foundation of China(No.81202403);West China HospitalChengdu Science and Technology Department Translational Medicine Innovation Foundation(No.ZH13039); A simple and efficient cascade Michael/cyclization reaction of 3-aminoindolin-2-ones with enones/enals was identified for the synthesis of potentially biologically active 3＇,4＇-dihydrospiro[pyrrol-3,2＇-oxindoles], ...; 关键词：cyclization glycol cascade starting analog biologically diverse potentially pyrrolidine spiro

Catalyst and Solvent-Free Microwave Assisted Expeditious Synthesis of 3-Indolyl-3-hydroxy Oxindoles and Unsymmetrical 3,3-Di(indolyl)indolin-2-ones: 《International Journal of Organic Chemistry》2015年第2期108-118,共11页Prasanna K. Vuram C. Kabilan Anju Chadha; A simple and efficient method for the synthesis of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2-ones using microwave irradiation without catalyst and solvent is described. A series of 3-ind...; 关键词：CATALYST-FREE ISATIN INDOLE Microwave SOLVENT-FREE

Design, Synthesis and Antitumor Activity of Novel Indolin-2-one Derivatives Containing 4-Thiazolidinone Moiety: 《Chemical Research in Chinese Universities》2015年第2期235-243,共9页LIU Zijian HOU Yunlei ZHANG Guogang XU Ning MI Bin GONG Ping ZHAO Yanfang; Supported by the Program for Innovative Research Team of the Ministry of Education of China and the Program for Liaoning Innovative Research Team in University, China（No.IRT1073）, and the National Natural Science Foundation of China （No.81202405）; A series of novel indolin-2-one derivatives containing 4-thiazolidinone moiety（7a--7r） were synthesized and evaluated for their in vitro antitumour activities against MDA-MB-231 （human breast cancer）, H460（human ...; 关键词：lndolin-2-one 4-THIAZOLIDINONE Antitumour activity

Synthesis, separation and NMR analysis of geometrical isomers of 3-benzylidene-indolin-2-one derivatives: 《Journal of Chinese Pharmaceutical Sciences》2014年第12期858-865,共8页李凌宇施伦勇梁鸿张庆英; National Natural Science Foundation of China(Grant No.21172008 and 21372015); A series of E and Z-isomers of 3-（4＇-substituted benzylidene）-indolin-2-one derivatives were synthesized and separated. Based on their 1H NMR characterization, an unusual counterintuitive deshielding phenomenon for...; 关键词：3-Benzylidene-indolin-2-one Geometrical isomers Deshielding phenomenon NMR analysis

Synthesis and cytotoxic evaluation of hybrids of indolin-2-one and quinazoline-4(3H)-one linked via carbon-carbon double bond: 《Journal of Chinese Pharmaceutical Sciences》2014年第11期765-771,共7页史博颖张晶晶曹胜利高曼丁盼盼李中峰廖蓟许兴智; National Natural Science Foundation of China (Grant No.20972099,31130017);Beijing Municipal Commission of Education (Grant No.KZ201210028035);Scientific Research Base Development Program of the Beijing Municipal Commission of Education;the 973 Project (Grant No.2013CB911000); A novel series of compounds combining indolin-2-one and quinazolin-4（3H）-one moiety via a carbon-carbon double bond were synthesized by aldol-condensation of 2-methylquinazolin-4（3H）-one-6-carbaldehyde with variou...; 关键词：INDOLIN-2-ONE Quinazolin-4（3H）-one Cytotoxic activity

Synthesis and Crystal Structure of(Z)-5-fluoro-3-(phenyl((5-(pyridin-3-ylmethyl)thiophen-2-yl)amino)methylene)Indolin-2-one被引量：1: 《Chinese Journal of Structural Chemistry》2013年第10期1586-1590,共5页丁磊金秋黄伟唐锋韦萍; Sponsored by the Natural Science Foundation of Jiangsu Province(No.BK2011088); The crystal structure of the title compound （Z）-5-fluoro-3-（phenyl（（5-（pyridin-3- ylmethyl）thiophen-2-yl）amino）methylene） indolin-2-one （C25H18FN3OS, Mr = 427.50） has been prepared and determined by single...; 关键词：INDOLE single-crystal X-ray diffraction crystal structure synthesis

Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review: 《Pharmacology & Pharmacy》2012年第1期62-71,共10页Chinnasamy Rajaram Prakash Panneerselvam Theivendren Sundararajan Raja; The kinases have been intensely studied because of their involvement in regulating essential cellular activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, pro...; 关键词：ISATIN ENZYME INHIBITION ANTICANCER

Design,synthesis,antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives被引量：1: 《Acta Pharmacologica Sinica》2007年第1期140-151,152,共13页Hai-hong LI Xiu-hua ZHANG Jin-zhi TAN Li-li CHEN Hong LIU Xiao-min LUO Xu SHEN Li-ping LIN Kai-xian CHEN Jian DING3, Hua-liang JIANG; Project supported by the State Key Program of Basic Research of China(No 2002CB512802);the 863 Hi-Tech Program(No 2002AA233061 and 2003AA235011);the National Natural Science Foundation of China(No 20372069,29725203 and 20472094).; Aim： To design and synthesize a novel class of antitumor agents, featuring the 3, 5-substituted indolin-2-one framework. Methods： Based on enzyme binding features of （Z）-SU5402, introducing a β-pyrrole group at t...; 关键词：protein-tyrosine kinase INDOLIN-2-ONE antitumor drug screening assays drugdesign molecular models

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