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ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

Identification of PRDX6 as a regulator of ferroptosis被引量：22: 《Acta Pharmacologica Sinica》2019年第10期1334-1342,共9页Bin Lu Xiao-bing Chen Yu-cai Hong Hong Zhu Qiao-jun He Bo Yang Mei-dan Ying Ji Cao; This work was supported by grants from the National Natural Science Foundation of China(No.81872885 to Ji Cao;No.81625024 to Bo Yang);the Department of Education of Zhejiang Province(Y201430401 to Ji Cao);the Talent Project of Zhejiang Association for Science and Technology(No.2018YCGC002 to Ji Cao);the Project of Zhejiang Medical Science and Technology(2015KYA141 to Yu-cai Hong).; Ferroptosis is a newly characterized iron-dependent form of nonapoptotic regulated cell death triggered by lipid reactive oxygen species(LOOH).The dysregulation of ferroptosis is highly related to cancer,and the induc...; 关键词：PRDX6 ferroptosis iPLA2 ACTIVITY HEME oxygenase-1 ANTITUMOR THERAPY

Computation of Structure Activity and Design of Chalcone Derivatives: 《Computational Chemistry》2019年第2期51-58,共8页Yan Jiang Qi Yang Shuping Zhang; Based on the antitumor activity of chalcone derivatives and their structure, the structure-activity relationship of chalcone derivatives was analyzed by CoMFA (comparative molecular field analysis) method and then the...; 关键词：Three Dimensional-Quantitative Structures ACTIVITY Relationship CHALCONE DERIVATIVES COMPARATIVE Molecular Field Analysis ANTITUMOR ACTIVITY

Pharmacological Mechanism of Isoliquiritigenin Antitumor: 《Medicinal Plant》2019年第1期17-18,共2页Hui XUE Jiaru WANG Wanting XU Yi ZHANG Yinghua LUO Chenghao JIN; Supported by Multigrain Production and Processing Characteristic Discipline Construction Project;the Postdoctoral Scientific Research Foundation of Heilongjiang Province of China(LBH-Q13132);National Key Research and Development Plan(2017YFD0401203); Isoliquiritigenin could play an antitumor role by inhibiting proliferation of tumor cells, inducing apoptosis of tumor cells and resisting neovascularity. In this paper, antitumor activity and mechanism of isoliquirit...; 关键词：ISOLIQUIRITIGENIN ANTITUMOR ACTIVITY CELL PROLIFERATION APOPTOSIS

Antitumor Research on Artemisinin and Its Bioactive Derivatives被引量：8: 《Natural Products and Bioprospecting》2018年第4期303-319,共17页Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang PSaravana Prabha Zhili Zuo; supported by CAS"Light of West China"Program([2014]91 to Z.Z.);the Basic Research Plan of Yunnan Provincial Science and Technology Department(grant number 2014FA042);CAS Strategic biological resources service network(ZSTH-021);the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA12030206.; Cancer is the leading cause of human death which seriously threatens human life.The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties.Simultaneously,a varie...; 关键词：ARTEMISININ Artemisinin derivatives ANTITUMOR ACTIVITY MECHANISM

Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs: 《International Journal of Organic Chemistry》2018年第1期115-124,共10页María L. Arias Eugenia Corrales Rebeca Poveda Jorge A. Cabezas; Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the na...; 关键词：Jacaranone Jacaranone SYNTHETIC ANALOGS ANTITUMOR ACTIVITY

Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds被引量：1: 《Acta Biochimica et Biophysica Sinica》2013年第2期87-94,共8页Xiaojin Ma Dongliang Liu Haishu Tang Yan Wang Ting Wu Yang Li Jie Yang Jianhua Yang Surong Sun Fuchun Zhang; A novel antifungal protein, designated as PHP, was isolated from the seeds of Peganum harmala, by cationic exchange chromatography on Resource S column and gel filtration on Sephadex 75 10/300 GL column. PHP was found...; 关键词：Peganum harmala lipid transfer proteins antifungal activity ANTITUMOR anti-HIV-1 reversetranscriptase activity

Experimental Study of the Antitumor Activity of Polymetalacrylates against Animal Transplantable Tumors被引量：1: 《Journal of Cancer Therapy》2010年第2期59-65,共7页Larisa A. Ostrovskaya M. G. Voronkov D. B. Korman M. M. Fomina N. V. Bluhterova V. A. Rikova K. A. Abzaeva L. V. Zhilitskaya; The antitumor activity of the fourteen polymetalacrylates against two models of murine solid tumors (Lewis lung carcinoma and Acatol adenocarcinoma) as well as the acute toxicity of these compounds has been studied. I...; 关键词：Polymetalcrylates ANTITUMOR ACTIVITY Transplantable TUMORS of ANIMALS

Antitumor mechanism of VP-16: A pulse radiolysis study被引量：1: 《Science China Chemistry》2002年第4期394-397,共4页汪世龙王玫倪亚明姚思德李文哲孙晓宇刘仕姮张超杰; This work was supported by the National Natural Science Foundation of China (Grant No. 39700029).; The antitumor mechanism of etoposide (VP-16) is investigated using pulse radiolysis technology. The oxidizing mechanism of VP-16 is studied by sodium persulfate, and the reaction rate constant is 4.04× 109 L· mol-1 ...; 关键词：podophyllotoxin VP-16 PULSE RADIOLYSIS ANTITUMOR activity.

Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin被引量：2: 《Science China Chemistry》2002年第2期191-199,共9页孙晓宇汪世龙倪亚明张超杰王玫姚思德; This work was supported by the National Natural Science Foundation of China (Grant No. 39700029).; Time-resolved laser flash photolysis and pulse radiolysis have been used to study the chemical activity of podophyllotoxin(PPT) and etoposide(VP-16). The mechanism of photoionization of etoposide and podophyllotoxin h...; 关键词：podophyllotoxin VP-16 laser flash photolysis PULSE radiolysis ANTITUMOR activity.

Synthesis and Antitumor Activity of Podophyllotoxin Analogues: 《Journal of Chinese Pharmaceutical Sciences》1998年第4期15-18,共4页鲁宽科刘方明陈耀祖; Seven podophyllotoxin analogues were synthesized by condensation of 4′ demethyl epipodophyllotoxin 10 with 5 alkyl 4 amino 3 mercapto 1,2,4 triazoles 9(a g) in the presence of TFA(CF 3COOH). Their antitumo...; 关键词：Podophyllotoxin Antitumor activity 1 2 4 Triazoles

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