ANTIDEPRESSANT-LIKE

作品数：9被引量：21H指数：2
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Rapid Antidepressant-Like Potential of Chaihu Shugan San Depends on Suppressing Glutamate Neurotransmission and Activating Synaptic Proteins in Hippocampus of Female Mice被引量：1
《Chinese Journal of Integrative Medicine》2024年第8期692-700,共9页LU Chao GAO Zi-wei XING Shan WANG Hui-hui HUANG Yun-ke ZHOU Hang WU Lei 
Supported by the National Natural Science Foundation of China(No.82174107,82304898);Jiangsu Provincial Administration of Traditional Chinese Medicine Fund(No.YB2020014);the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.035062005001)。
Objective To explore the rapid antidepressant potential and the underlying mechanism of Chaihu Shugan San(CSS)in female mice.Methods Liquid chromatography mass spectrometry(LC-MS)/MS was used to determine the content ...
关键词：Chaihu Shugan San female rapid antidepressant potential N-methyl-D-aspartate receptor synapticprotein optogenetic Chinesemedicine 
Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice:Highlighting effects on behaviour,oxidative stress,and neuroinflammation
《World Journal of Pharmacology》2022年第3期27-47,共21页Adejoke Yetunde Onaolapo Hameed Sulaiman Anthony Tope Olofinnade Olakunle James Onaolapo 
BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract...
关键词：Behavioural despair Depression Mental Health Neurobehaviour Neuromorphology 
Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain被引量：12
《Neuroscience Bulletin》2019年第4期661-672,共12页Yang Li Jing Liu Xu Liu Cun-Jin Su Qi-Lin Zhang Zhi-Hong Wang Lei-Fang Cao Xue-Yan Guo Ya Huang Weifeng Luo Tong Liu 
supported by grants from the National Natural Science Foundation of China (81870874, 31371179, 81300968, and 81671270);the Natural Science Foundation of Jiangsu Province, China (BK20170004, 2015-JY-029, and BK20140372);Jiangsu Key Laboratory of Neuropsychiatric Diseases (BM2013003);the Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding (XKQ2015002);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17-2000);Suzhou Science and Technology For People’s Livelihood (SYS201706);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17_2034)
The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single faci...
关键词：BOTULINUM NEUROTOXIN Depression 5-HT BDNF HIPPOCAMPUS 
Antidepressant-Like Activity of Methanolic Extract of the Seeds of <i>Trachysperum ammi</i>in Swiss Albino Mice
《Pharmacology & Pharmacy》2018年第12期503-514,共12页Md. Rashidur Rahman Mohammad Ali Mostakim Sharif Sadiur Rahman Sajon Md. Abdul Mannan Md. Shahed-Al-Mahmud 
Trachysperum ammi has been traditionally used for the treatment of neurological disorders such as depression and anxiety. To date, T. ammi has reported for its chemical constituents in different diseases condition. Th...
关键词：Trachysperum AMMI ANTIDEPRESSANT CNS STIMULANTS Forced Swimming 
Traditional herbal formula Sini Powder extract produces antidepressantlike effects through stress-related mechanisms in rats被引量：5
《Chinese Journal of Natural Medicines》2016年第8期590-598,共9页WEI Shan-Shan YANG He-Jin Huang Jia-Wen LU Xue-Ping PENG Ling-Fang WANG Qing-Guo 
supported by the National Basic Research Program funded by Ministry of Science and Technology of People’s Republic of China(No.2011CB505100)
Sini Powder(SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated w...
关键词：Sini Powder extract ANTIDEPRESSANT-LIKE Hypothalamic-pituitary-adrenal axis Glucocorticoid receptor 
Xylocarpin H, a Limonoid of <i>Xylocarpus granatum</i>, Produces Antidepressant-Like Activities in Mice被引量：1
《Journal of Behavioral and Brain Science》2015年第11期524-532,共9页Xi Yin Xin Li Yaoguang Hao Yiwen Zhao Jinghong Zhou Haishui Shi 
Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, a...
关键词：Depression Xylocarpin H Tail Suspension TEST Forced Swimming TEST Hypothalamic-Pituitary-Adrenal Axis 
Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice被引量：1
《Acta Pharmacologica Sinica》2015年第8期949-956,共8页Zhao-fu SHENG Xiang-yu CUI Su-ying CUI Bin YU Xue-qiong ZHANG Sheng-jie LI Qing CAO Yuan-li HUANG Ya-ping XU Jin-zhi SONG Hui DING Zhi-ge LIN Guang YANG Yong-he ZHANG 
Aim： 7-O-ethylfangchinoline （YH-200） is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant- like action and underlying mechanisms of YH-200 in mice. Methods： Mice weret...
关键词：depression ANTIDEPRESSANT 7-O-ethylfangchinoline TETRANDRINE ADRENOCEPTOR dopamine receptor AMPA receptor forced swimming test tail suspension test 
Modulation of Neurotransmission by a Specified Oregano Extract Alters Brain Electrical Potentials Indicative of Antidepressant-Like and Neuroprotective Activities
《Neuroscience & Medicine》2012年第1期37-46,共10页M. Hasan Mohajeri Regina Goralczyk Wilfried Dimpfel 
Different behavioral states are characterized by distinct patterns of global brain activity. Therefore, the biological effects of herbal extracts on brain functions can be assessed by analyzing the local field potenti...
关键词：EEG Dopamine SEROTONIN NORADRENALIN OréVida Diet MOOD Therapy 
Antidepressant-Like Activity of Tetramethylpyrazine Measured by Chronic Experimental Method in Rat Model of Depression被引量：1
《Pharmacology & Pharmacy》2012年第1期52-57,共6页Lijian Yu Xiaodan Jiang Yongping Zhang Mingneng Liao Rundi Ma Tingxi Yu 
The aim of this study was to investigate the potential antidepressive-like effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, i...
关键词：TETRAMETHYLPYRAZINE Antidepressive-Like ACTIVITY CHRONIC MILD Stress Rats 
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