POLYMORPHISMS

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Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution
《World Journal of Gastrointestinal Oncology》2025年第1期101-109,共9页Mariarosaria D'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno 
BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD gene.About 7%of the European population is a carrier of DPYD gene polymorphisms associat...
关键词：Dihydropyrimidine dehydrogenase DPYD polymorphisms FLUOROPYRIMIDINE Caucasian population Gastrointestinal cancers 
Characterization and strong risk association of TLR2 del-196 to-174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer被引量：1
《World Journal of Gastrointestinal Oncology》2020年第5期535-548,共14页Caroline de Matos Lourenco Manoela Dias Susi Mariah Cristina Antunes do Nascimento Vilson Serafim Junior Ana Paula Simedan Vila Gabriela Helena Rodrigues-Flemming Eny Maria Goloni-Bertollo Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo 
Supported by the Sao Paulo Research Foundation,No2013/14022-6 and No.2014/17716-1
BACKGROUND Toll-like receptor-2(TLR2) is responsible for recognizing Helicobacter pylori(H.pylori) and activating the immune response. Polymorphisms in TLR2 may modulate gastric carcinogenesis.AIM To evaluate whether ...
关键词：Toll-like receptor 2 Helicobacter pylori Gastric cancer Chronic gastritis POLYMORPHISMS Gene expression 
Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population被引量：10
《World Journal of Gastrointestinal Oncology》2019年第11期998-1010,共13页Manoela Dias Susi de Matos Lourenco Caroline Lucas Trevizani Rasmussen Spencer Luis Marques Payao Ana Flavia Teixeira Rossi Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo 
Supported by The Sao Paulo Research Foundation(FAPESP),NO.2013/14022-6 and NO.2014/17716-1
BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single...
关键词：Toll-like receptor 9 Helicobacter pylori Gastric cancer Chronic gastritis POLYMORPHISMS Gene expression 
Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients被引量：4
《World Journal of Gastrointestinal Oncology》2017年第2期78-86,共9页Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg 
AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective co...
关键词：Colorectal cancer Genetic polymorphisms Vascular endothelial growth factor-A Colorectal surgery Genetic variation 
Polymorphisms in mucin genes in the development of gastric cancer被引量：6
《World Journal of Gastrointestinal Oncology》2015年第11期328-337,共10页Rong Wen Fang Gao Cheng-Jiang Zhou Yan-Bin Jia 
Supported by National Natural Science Foundation of China,No.30960169 and No.81250024;Natural Science Foundation of Inner Mongolia,No.2011MS1103;Inner Mongolian Committee of Science and Technology,China,No.20110501
Gastric cancer(GC) is the third leading cause of cancerrelated death worldwide.In areas of high prevalence,such as Japan,South Korea and China,most cases of GC are related to Helicobacter pylori(H.pylori),which involv...
关键词：GASTRIC cancer HELICOBACTER PYLORI GENETIC polymor 
Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan被引量：1
《World Journal of Gastrointestinal Oncology》2010年第8期326-331,共6页Mei-Due Yang Ru-Yin Tsai Chiu-Shong Liu Chao-Hsiang Chang Hwei-Chung Wang Yung-An Tsou Chung-Hsing Wang Cheng-Chieh Lin Song-Kun Shyue Da-Tian Bau 
Supported by Research Grants from the China Medical Universityand Hospital (DMR-99-041 and CMU-99-NTU-10);the Terry FoxCancer Research Foundation and the National Science Council(NSC 98-2320-B-039-010-MY3)
AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwan Residents population. METHODS: Three hundred and sixty-two patients with colorectal cancer ...
关键词：CAVEOLIN-1 COLORECTAL cancer CARCINOGENESIS Polymorphism SMOKING 
Role of interleukin polymorphisms in gastric cancer: “Pros and cons”
《World Journal of Gastrointestinal Oncology》2010年第6期265-271,共7页Francesco Perri Fulvia Terracciano Marco Gentile Antonio Merla Daniela Scimeca Angelo Zullo 
Helicobacter pylori (H. pylori ) infection is the leading cause of gastric cancer worldwide. Infection with this bacterium causes a chronic active immune response that persists for the life of the host. The combinatio...
关键词：CYTOKINE GASTRIC cancer Gene INTERLEUKIN HELICOBACTER PYLORI Polymorphism 
Recent advances in understanding of interactions between genes and diet in the etiology of colorectal cancer
《World Journal of Gastrointestinal Oncology》2010年第3期125-129,共5页Lynnette R Ferguson 
Supported by Foundation for Research,Science and Technology,C02X0403:Gene-specific Foods
At an international level, colorectal cancer (CRC) is a major cause of morbidity and mortality. Diet plays a major etiologic role, and a range of putative dietary carcinogens have been identified. The probability with...
关键词：TRANSFORMING growth factor β COLORECTAL cancer Single NUCLEOTIDE POLYMORPHISMS Genome wide association studies Gene expression 
Undefined familial colorectal cancer
《World Journal of Gastrointestinal Oncology》2009年第1期12-20,共9页Constantinos Pantelis Zambirinis George Theodoropoulos Maria Gazouli 
Colorectal cancer(CRC),one of the most common cancers of the world,is actually a spectrum of several subtypes,with different molecular profiles,clinicopathological characteristics and possibly separate pathways of pro...
关键词：COLORECTAL CANCER FAMILIAL Undefined TYPE X POLYMORPHISMS 
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