POLYMORPHISMS

作品数：634被引量：2320H指数：17
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Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
《Cell Research》2024年第12期859-872,共14页Ting Zhao Xueying Guan Yan Hu Ziqian Zhang Han Yang Xiaowen Shi Jin Han Huan Mei Luyao Wang Lei Shao Hongyu Wu Qianqian Chen Yongyan Zhao Jiaying Pan Yupeng Hao Zeyu Dong Xuan Long Qian Deng Shengjun Zhao Mengke Zhang Yumeng Zhu Xiaowei Ma Zequan Chen Yayuan Deng Zhanfeng Si Xin Li Tianzhen Zhang Fei Gu Xiaofeng Gu Lei Fang 
This work was financially supported in part by grants from the Biological Breeding-Major Projects(2023ZD04076);the National Natural Science Foundation of China(32341024);Fundamental Research Funds for the Central Universities(226-2022-00100;226-2024-00205);the Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies.
DNA methylation plays multiple regulatory roles in crop development.However,the relationships of methylation polymorphisms with genetic polymorphisms,gene expression,and phenotypic variation in natural crop population...
关键词：breeding alone COTTON 
Factors inducing morphological transition in harmful algal bloom-forming species Phaeocystis globosa with emphasis on predator chemical cue被引量：1
《Journal of Oceanology and Limnology》2023年第4期1537-1546,共10页Xiao YANG Pingping SHEN Ke LI 
Supported by the Key Deployment Project of Center for Ocean Mega-Science,Chinese Academy of Sciences(No.COMS2019R04);the National Overseas High-level Talent Project,Taishan Scholar Program from Shandong Province of China(No.tsqn20190403);the Shuangbai Plan from Yantai City(No.2018020)。
The microalga Phaeocystis globosa is recognized as a harmful alga and also one of the few keystone phytoplankton genera that shape the structure and function of marine ecosystems.P.globosa possess a complex polymorphi...
关键词：Phaeocystis globosa POLYMORPHISMS harmful algal blooms defense strategies INFOCHEMICAL 
HTPdb and HTPtools:Exploiting maize haplotypetag polymorphisms for germplasm resource analyses and genomics-informed breeding被引量：2
《Plant Communications》2022年第4期54-63,共10页Yikun Zhao Hongli Tian Chunhui Li Hongmei Yi Yunlong Zhang Xiaohui Li Han Zhao Yongxue Huo Rui Wang Dingming Kang Yuncai Lu Zhihao Liu Ziyue Liang Liwen Xu Yang Yang Ling Zhou Tianyu Wang Jiuran Zhao Fengge Wang 
supported by grants from the 13th Five-Year National Key R&D Program of China(2017YFD0102001).
Along with rapid advances in high-throughput-sequencing technology,the development and application of molecular markers has been critical for the progress that has been made in crop breeding and genetic research.Desir...
关键词：haplotype tag database MAIZE pedigree reconstruction heterotic-pattern prediction genomicsinformed breeding 
Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population被引量：1
《Biomedical and Environmental Sciences》2019年第7期550-553,共4页WANG Yan HAN Han WANG Jun SHEN Fang YU Fei WANG Ling YU Song Cheng ZHANG Dong Dong SUN Hua Lei XUE Yuan BA Yue WANG Chong Jian LI Wen Jie 
supported by the National Nature Science Foundation of China [grants number 81872626,81573151,U1204823,and 81573243];Science and Technology Foundation for Innovation Talent of Henan Province [No.154200510010]
Vitamin D, a fat-soluble vitamin and endocrine horm one, and it impacts various bone and extra-bone health, such as osteoporosis, diabetes, and cancer. The main circulating form of vitamin D is 25-hydroxyvitamin D [25...
关键词：POLYMORPHISMS CYP2R1 GENE SERUM VITAMIN D CHINESE RURAL Population 
Association between NFE2L2 Gene Polymorphisms and Noise-induced Hearing Loss in a Chinese Population被引量：2
《Biomedical and Environmental Sciences》2019年第6期465-470,共6页WANG Bo Shen XU Kai ZHANG Hong PU Yue Pu YIN Li Hong HAN Lei CHEN Lin WANG Ning ZHU Bao Li ZHANG Juan 
supported by Outstanding Medical Academic Leaders program of Jiangsu Province [LJ201130];Jiangsu Provincial Youth Medical Talent program [QNRC2016536];Six Talent Peaks Project in Jiangsu Province [WSW-017];Preventive Medicine Foundation of Jiangsu [Y2015049];The Fundamental Research Funds for the Central Universities [3225009404]
Occupatio nal n oise is among the most comm on risks associated with the wellbeing of employees. Occupational exposure to noise causes disabling hearing loss in 16% of adults worldwide.It has bee n ack no wledged that...
关键词：NFE2L2 GENE POLYMORPHISMS CHINESE POPULATION 
Association of Vitamin D Receptor Gene Polymorphisms with Metabolic Syndrome in Rural Areas of China被引量：1
《Biomedical and Environmental Sciences》2019年第4期304-308,共5页WANG Jun WANG Yan HAN Han WANG Teng SHEN Fang LI Wen Jie LI Xing 
supported by the National Nature Science Foundation of China [grants number 81872626,81573151,U1204823,and 81573243];Science and Technology Foundation for Innovation Talent of Henan Province [grants number 1542005 10010];Dietary Nutrition Research and Education Foundation of Danone [grants number DIC2013-06]
Metabolic Syndrome (MS) is a combination of multiple complex diseases, whose etiology is complicated and has many influencing factors Randomized controlled trials have shown that vitamin D supplementation could delay ...
关键词：VITAMIN D RECEPTOR GENE POLYMORPHISMS 
Unique characteristics of the genetics epidemiology of amyotrophic lateral sclerosis in China被引量：7
《Science China(Life Sciences)》2019年第4期517-525,共9页Qianqian Wei Xueping Chen Yongping Chen Ruwei Ou Bei Cao Yanbing Hou Lingyu Zhang Hui-Fang Shang 
supported by the funding of the National Natural Science Foundation of China(81371394);the National Key Research and Development Program of China(2016YFC0901504)
Continual discoveries of new genes and unraveling the genetic etiology in amyotrophic lateral sclerosis(ALS) have provided greater insight into the underlying pathogenesis in motor neuron degeneration, as well as faci...
关键词：amyotrophic lateral SCLEROSIS gene mutation single NUCLEOTIDE POLYMORPHISMS 
Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring
《Acta Biochimica et Biophysica Sinica》2019年第3期341-343,共3页Luyue Qi Shoukui Xiang Li Li Jinwei He Wenzhen Fu Yujuan Liu Yunqiu Hu Zhenlin Zhang 
the grants from the National Basic Research Program of China(no.2014CB942903);the National Natural Science Foundation of China(no.81370978);the Science and Technology Commission of Shanghai Municipality(no.14JC1405000).
Peak bone mineral density(BMD)achieved during early adulthood is a highly heritable trait and a strong determinant of subsequent osteoporotic fracture risk.Evidence has already suggested that 50–80% of the variance i...
关键词：SOST gene POLYMORPHISMS bone mineral density(BMD) OSTEOPOROTIC fracture 
GPA: A Microbial Genetic Polymorphisms Assignments Tool in Metagenomic Analysis by Bayesian Estimation被引量：1
《Genomics, Proteomics & Bioinformatics》2019年第1期106-117,共12页Jiarui Li Pengcheng Du Adam Yongxin Ye Yuanyuan Zhang Chuan Song Hui Zeng Chen Chen 
supported by the Beijing Municipal Science & Technology Commission (Grant No. Z161100000516021);the National Key R&D Program of China (Grant No. 2016YFC1200804);the National Natural Science Foundation of China (Grant Nos. 81571956 and 81702038)
Identifying antimicrobial resistant(AMR) bacteria in metagenomics samples is essential for public health and food safety. Next-generation sequencing(NGS) technology has provided a powerful tool in identifying the gene...
关键词：Next-generation sequencing Pool-seq Bayesian model METAGENOMICS Genetic POLYMORPHISMS 
Significant Polymorphisms of Vitamin D Receptor Gene(rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area被引量：1
《Biomedical and Environmental Sciences》2019年第1期58-62,共5页HAN Han ZHAO Ming Xu WANG Yan WANG Jun REN Bing Nan GE Hui Na WANG Teng SUN Bei Bei BA Yue LI Wen Jie 
supported by grants from the National Natural Science Foundation of China[81573151,81872626,and81573243];Science and Technology Foundation for Innovation Talent of Henan Province[154200510010];Dietary Nutrition Research and Education Foundation of Danone[DIC2013-06]
Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetes cases and results in severe complications. It is a multifactorial metabolic disorder that results from a combination of resistance to insulin action and...
关键词：VITAMIN D Type 2 diabetes MELLITUS (T2DM) INSULIN 
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