SUBPOPULATION

作品数:48被引量:129H指数:5
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相关领域:医药卫生更多>>
相关作者:张继甄小芳更多>>
相关机构:中山大学首都医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国科学院知识创新工程北京市自然科学基金更多>>
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Single-cell and bulk transcriptomics identifies a tumor-specific CD36^(+)cancer-associated fibroblast subpopulation in colorectal cancer
《Cancer Communications》2024年第4期495-498,共4页Jin Wang Ming-Jia Xi Qing Lu Bi-Han Xia Yu-Zhi Liu Jin-Lin Yang 
supported by grants from the National Natural Science Foundation of China(No.82173253);the Sichuan Province Science and Technology Support Program(No.2022YFH0003 and No.2023NSFSC1900);the Postdoctoral Research Foundation of China(No.2022M712260).
Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their v...
关键词:CD36 metabolism colorectal 
Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome
《Congenital Heart Disease》2024年第2期233-246,共14页Xiaozhuo Xu Yilin Huang Xu Han 
supported by Jiangsu Province Postgraduate Practice Innovation Program(SJCX22_0766);Natural Science Foundation of Jiangsu Province(BK20231378);Leader of Geriatric Clinical Technology Application Research Project of Jiangsu Provincial Health Commission(LR2022002)。
Background:Hypoplastic left heart syndrome(HLHS)is one of the most challenging congenital heart diseases in clinical treatment.In cardiac tissues,resident macrophages fulfill critical functions in maintaining a stable...
关键词:Hypoplastic left heart syndrome single-nucleus RNA sequencing MACROPHAGE cellular subpopulation transcription factor 
Phenotype-Directed DNA Nanomachine for in Situ Analysis of Stem Cell-like Subpopulation in Breast Cancer
《CCS Chemistry》2024年第4期1034-1046,共13页Ya Cao Huiru Mao Lingjun Sha Qi Liu Bing Han Jing Zhao Genxi Li 
the National Natural Science Foundation of China(grant nos.81972799 and 81871449);the Natural Science Foundation of Shanghai(grant no.23ZR1421400).
The cancer stem cell hypothesis provides a basis for prediction of the recurrence and risk of metastasis in breast cancer.However,the unique expression pattern of stemness markers and the presence of nonstem-like canc...
关键词:breast cancer DNA nanomachine stem cell-like subpopulation electrochemical determination single-step isolation phenotypic analysis 
Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha Subpopulation to Aid Forensic Profiling:Pilot Study
《Journal of Forensic Science and Medicine》2024年第1期11-19,共9页Vaishali Amarlal Sadhwani Nilima Prakash GLPradeep Rekha Patil Shubhechha Anand Khivsara Sabiha Mokashi Khan 
Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial identification.Many studies have demonstrated the differences in the expression and frequen...
关键词:Cusp number ETHNICITY forensic anthropology MOLAR protostylid 
Apalutamide for metastatic castration-sensitive prostate cancer:final analysis of the Asian subpopulation in the TITAN trial
《Asian Journal of Andrology》2023年第6期653-661,共9页Byung Ha Chung Jian Huang Hiroji Uemura Young Deuk Choi Zhang-Qun Ye Hiroyoshi Suzuki Taek Won Kang Da-Lin He Jae Young Joung Sabine D Brookman-May Sharon McCarthy Amitabha Bhaumik Anildeep Singh Suneel Mundle Simon Chowdhury Neeraj Agarwal Ding-Wei Ye Kim N Chi Hirotsugu Uemura 
The study was funded by Janssen Pharmaceutical Ltd.Writing assistance was provided by Katherine A Lyseng-Williamson and Kerry Dechant,ISMPP CMPP^(TM),on behalf of Content Ed Net,and was funded by Janssen Pharmaceutical Ltd.Janssen Pharmaceutical Ltd.is not involved in the process of experimental design,results,or discussion,and has no competing interests with this study.
The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial showed improvement in overall survival(OS)and other efficacy endpoints with apalutamide plus androgen de...
关键词:apalutamide Asia event-driven analysis metastatic castration-sensitive prostate cancer overall survival 
Single-Cell RNA Sequencing Reveals Potential for Endothelial-to-Mesenchymal Transition in Tetralogy of Fallot
《Congenital Heart Disease》2023年第6期611-625,共15页Aisa Zulibiya Jing Wen Huiqing Yu Xiaoming Chen Lei Xu Xiao Ma Baojian Zhang 
supported by The National Natural Science Foundation of China(No.82160050);State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia(No.SKL-HIDCA-2021-24).
Background:Tetralogy of Fallot(TOF)is a very common cyanotic congenital heart disease.Endothelial-to-mesenchymal transition(EndoMT)is recognized as a physiological mechanism involved in embryonic heart development and...
关键词:Tetralogy of Fallot endothelial cells endothelial-mesenchymal transition congenital heart disease cellular subpopulation 
Distinct mononuclear diploid cardiac subpopulation with minimal cell-cell communications persists in embryonic and adult mammalian heart被引量:1
《Frontiers of Medicine》2023年第5期939-956,共18页Miaomiao Zhu Huamin Liang Zhe Zhang Hao Jiang Jingwen Pu Xiaoyi Hang Qian Zhou Jiacheng Xiang Ximiao He 
supported by the National Key Research and Development Program of China (No.2021YFA1101901);the Fundamental Research Funds for the Central Universities,HUST (No.2021GCRC073).
A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illu...
关键词:mononuclear diploid cardiomyocytes cell-cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration 
SV2B defines a subpopulation of synaptic vesicles
《Journal of Molecular Cell Biology》2023年第9期1-13,共13页Isabelle Paulussen Hannes Beckert Timothy FMusial Lena J.Gschossmann Julia Wolf Mathieu Schmitt Jérôme Clasadonte Georges Mairet-Coello Christian Wolff Susanne Schoch Dirk Dietrich 
supported by grants from Deutsche Forschungsgemeinschaft(DFG)(SFB1089,SCHO 820/4-1,SCHO 820/6-1,SCHO 820/7-1,SCHO 820/5-2,and SPP1757 to S.S.,SFB1089,SPP1757,INST117215,DI853/3-5&7,and INST 217/785-1 to D.D.),the BONFOR program of the University of Bonn Medical Center(S.S.and D.D.),and UCB Pharma.
Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein compositions.Here,we mapped the intrasynapt...
关键词:3D electron microscopy synaptic vesicles synaptic vesicle proteins ENDOCYTOSIS TRAFFICKING spatial organization 
A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome被引量:3
《Cellular & Molecular Immunology》2023年第8期908-923,共16页Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan 
supported in part by grants from the Beijing Natural Science Foundation of China(Grant No.7192123,7222117);the National Natural Science Foundation of China(Grant No.31770793,82000812);the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2018122).
As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneou...
关键词:Tumor-associated macrophages CD146 INFLAMMASOME TMEM176B Tumor immunotherapy 
Assessing parameter sensitivity in a university campus COVID-19 model with vaccinations
《Infectious Disease Modelling》2023年第2期374-389,共16页Meghan Rowan Childs Tony E.Wong 
From the beginning of the COVID-19 pandemic,universities have experienced unique challenges due to their dual nature as a place of education and residence.Current research has explored non-pharmaceutical approaches to...
关键词:COVID-19 VACCINATION SUBPOPULATION MODELING Sensitivity analysis UNIVERSITY 
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