supported by grants from the National Natural Science Foundation of China(No.82173253);the Sichuan Province Science and Technology Support Program(No.2022YFH0003 and No.2023NSFSC1900);the Postdoctoral Research Foundation of China(No.2022M712260).
Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their v...
supported by Jiangsu Province Postgraduate Practice Innovation Program(SJCX22_0766);Natural Science Foundation of Jiangsu Province(BK20231378);Leader of Geriatric Clinical Technology Application Research Project of Jiangsu Provincial Health Commission(LR2022002)。
Background:Hypoplastic left heart syndrome(HLHS)is one of the most challenging congenital heart diseases in clinical treatment.In cardiac tissues,resident macrophages fulfill critical functions in maintaining a stable...
the National Natural Science Foundation of China(grant nos.81972799 and 81871449);the Natural Science Foundation of Shanghai(grant no.23ZR1421400).
The cancer stem cell hypothesis provides a basis for prediction of the recurrence and risk of metastasis in breast cancer.However,the unique expression pattern of stemness markers and the presence of nonstem-like canc...
Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial identification.Many studies have demonstrated the differences in the expression and frequen...
The study was funded by Janssen Pharmaceutical Ltd.Writing assistance was provided by Katherine A Lyseng-Williamson and Kerry Dechant,ISMPP CMPP^(TM),on behalf of Content Ed Net,and was funded by Janssen Pharmaceutical Ltd.Janssen Pharmaceutical Ltd.is not involved in the process of experimental design,results,or discussion,and has no competing interests with this study.
The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial showed improvement in overall survival(OS)and other efficacy endpoints with apalutamide plus androgen de...
supported by The National Natural Science Foundation of China(No.82160050);State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia(No.SKL-HIDCA-2021-24).
Background:Tetralogy of Fallot(TOF)is a very common cyanotic congenital heart disease.Endothelial-to-mesenchymal transition(EndoMT)is recognized as a physiological mechanism involved in embryonic heart development and...
supported by the National Key Research and Development Program of China (No.2021YFA1101901);the Fundamental Research Funds for the Central Universities,HUST (No.2021GCRC073).
A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illu...
supported by grants from Deutsche Forschungsgemeinschaft(DFG)(SFB1089,SCHO 820/4-1,SCHO 820/6-1,SCHO 820/7-1,SCHO 820/5-2,and SPP1757 to S.S.,SFB1089,SPP1757,INST117215,DI853/3-5&7,and INST 217/785-1 to D.D.),the BONFOR program of the University of Bonn Medical Center(S.S.and D.D.),and UCB Pharma.
Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein compositions.Here,we mapped the intrasynapt...
supported in part by grants from the Beijing Natural Science Foundation of China(Grant No.7192123,7222117);the National Natural Science Foundation of China(Grant No.31770793,82000812);the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2018122).
As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneou...
From the beginning of the COVID-19 pandemic,universities have experienced unique challenges due to their dual nature as a place of education and residence.Current research has explored non-pharmaceutical approaches to...