MIMOTOPE

作品数：11被引量：27H指数：4
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相关领域：医药卫生更多>>
相关机构：中国疾病预防控制中心更多>>
相关期刊：《Cellular & Molecular Immunology》《World Journal of Gastroenterology》《Advances in Bioscience and Biotechnology》《Asian Pacific Journal of Tropical Medicine》更多>>
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Insights into therapeutic peptides in the cancerimmunity cycle:Update and challenges
《Acta Pharmaceutica Sinica B》2024年第9期3818-3833,共16页Xiaokun Zhang Ye Wu Jiayi Lin Shengxin Lu Xinchen Lu Aoyu Cheng Hongzhuan Chen Weidong Zhang Xin Luan 
the National Natural Science Foundation of China(Nos.82322073,82173846,and 82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009,China);Oriental Scholars of Shanghai Universities(TP2022081,China);China Postdoctoral Science Foundation(No.2021M702215);Jiangxi Province Thousand Talents Program(jxsq2023102168,China);Young Talent Lifting Project of Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Rising-Star Program(No.22QA1409100,China);Shanghai Sailing Program(No.22YF1445000,China);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800,China);Three-Year Action Plan for Three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021-2023)-0208 and ZY(2021-2023)-0401,China];High level Key Discipline of National Administration of Traditional Chinese Medicine(No.zyyzdxk-2023071,China);Innovation Team and Talents Cultivation Program of High level Key Discipline of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004,China);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302,China);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology(China).All figures were created with BioRender.com.
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity ...
关键词：Cancer-immunity cycle Oncolytic peptide Peptide neoantigen vaccine Peptide mimotope Immune checkpoint blockade Cancer immunotherapy Synthetic long peptide vaccine Peptide-major histocompatibility complex 
Mimotope peptide modified pompon mum-like magnetic microparticles for precise recognition,capture and biotransformation analysis of rituximab in biological fluids被引量：4
《Acta Pharmaceutica Sinica B》2024年第3期1317-1328,共12页Jiawen Yang Aixuan Zhou Minyi Li Qiaoxian He Jingwei Zhou Jacques Crommen Wentao Wang Zhengjin Jiang Qiqin Wang 
supported by the National Natural Science Foundation of China(82173773,82273893,82373829);the Natural Science Foundation of Guangdong Province,China(2021A0505030039,2021A0505020014);the High-End Foreign Experts Project,China(G2021199005L);the Science and Technology Program of Guangdong Provincial Medical Products Administration,China(2023TDZ11)。
Due to low immobilized ligand density,limited binding capacity,and severe interference from serum proteins,developing ideal peptide-based biomaterials for precise recognition and in vivo analysis of biopharmaceuticals...
关键词：Therapeutic monoclonal antibody Mimotope peptide Precise recognition Peptide-based biomaterials BIOTRANSFORMATION Patient serum 
Mimotope-based allergen-specific immunotherapy: ready for prime time?
《Cellular & Molecular Immunology》2019年第11期890-891,共2页Nicki Y.H.Leung Christine Y.Y.Wai Ka Hou Chu Patrick S.C.Leung 
INTRODUCTION Allergen-specific immunotherapy(AIT)is a therapeutic strategy to restore the normal immune response by suppressing inflammatory effector cells and inducing regulatory cells specific to the culprit allerge...
关键词：IMMUNOTHERAPY doses TREATMENT 
Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries被引量：7
《Cellular & Molecular Immunology》2017年第3期308-318,共11页Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung 
The one-bead-one-compound （OBOC） combinatorial peptide library is a powerful tool to identify ligand and receptor interactions. Here, we applied the OBOC library technology to identify mimotopes specific to the immu...
关键词：EPITOPE MIMOTOPE OBOC peptide library TROPOMYOSIN 
Recognition of a multiple antigen peptide containing sequence from mimotope of the dengue type 3 virus NS4B protein by human antibodies
《Asian Pacific Journal of Tropical Medicine》2016年第2期126-129,共4页Nevis Amin Maritza Pupo Alicia Aguilar Susana Vázquez Yamira Caballero Rolando Ochoa María G Guzmán Armando Acosta 
Objective: To evaluate the recognition of NS4 B mimotope, as multiple antigen peptide(MAP), by dengue antibodies presents in serum samples from patients with different serotype infections. Methods: A MAP containing mi...
关键词：MAP ANTIBODIES NS4B DENGUE VIRUS 
Isolation of mimotopes to the anti-human VEGF antibody Bevacizumab by mRNA display using random peptide libraries and the vaccination of a rabbit
《Advances in Bioscience and Biotechnology》2011年第2期97-102,共6页Teruaki Kobayash Tatsuro Shibui 
An mRNA display system using synthetic DNA cod-ing for random 10- and 20-amino-acid peptide li-braries was employed to isolate mimotopes that could substitute for the anti-human VEGF antibody Bevacizumab. After six ro...
关键词：RANDOM Peptide mRNA Display MIMOTOPE ANTIGEN Antibody Vaccine 
Oral attenuated Salmonella typhimurium vaccine against MG7-Ag mimotope of gastric cancer被引量：6
《World Journal of Gastroenterology》2005年第12期1833-1836,共4页Fan-PingMeng JieDing Zhao-CaiYu Quan-LiHan Chang-CunGuo NaLiu Dai-MingFan 
Supported by the National Natural Science Foundation of China, No. 39870742
AIM: To develop an oral attenuated Salmonella typhimurium vaccine against gastric cancer and to evaluate its efficacy in mice. METHODS: A complementary sequence of Nco Ⅰ site and a sequence coding for MG7-Ag mimotope...
关键词：Salmonella typhimuriunr Gastric cancer 
Screening and identification of mimotope of gastric cancer associated antigen MGb1-Ag被引量：2
《World Journal of Gastroenterology》2003年第9期1920-1924,共5页Zhe-YiHan Kai-ChunWu Feng-TianHe Quan-LiHan Yong-ZhanNie YingHan Xiao-NanLiu 3ian-YongZheng Mei-HongXu Dai-MingFan 
the National High Technology Research and Development Program(863 Program)of China,No.2001AA215421
AIM: Using a monoclonal antibody against gastric cancer antigen named MGbl to screen a phage-displayed random peptide library fused with coat protein plII in order to get some information on mimotopes.lV^37BODS: Throu...
关键词：胃癌 MGbl-Ag抗原 酶联免疫吸附试验 MIMOTOPE 
A mimotope of Pre-S_2 region of surface antigen of viral hepatitis B screened by phage display被引量：7
《Cell Research》2001年第3期203-208,共6页WU YU ZHANG, YING WAN, DAO GUO LI, YAN TANG, WEI ZHOU Institute of Immunology, PLA, The Third Medical University, Chongqing 400038, China Medical Center, General Hospital of Weifang, Weifang 26100, China 
Grants39789010 and 39700132 from the Natural ScienceFoundat,ion of China and agrant from National Ed-u~ation Ministery und
To acquire the phage-displayed mimotopes which mimic the specificity of hepatitis B virus surface antigen (HBsAg), a random peptide library expressing linear peptide with 12 amino asids in length were used to screen w...
关键词：MIMOTOPE hepatitis B virus raccine ANTIBODY 
Screening and identification of mimotopes of LPS conservative epitope from random phage display peptide library
《Journal of Medical Colleges of PLA(China)》2000年第4期262-265,共4页文维延 韩强涛 富宁 
Supported by Natural Science Foundation of Guangdong Province, No. 970334
Objective: To screen and identify the mimotopes of lipopolysaccharide (LPS) epitope. Methods: A random phage display dodecapeptide library was screened with monoclonal antibody 2B4 specifically against LPS conservativ...
关键词：PHAGE peptide library MIMOTOPE LIPOPOLYSACCHARIDE 
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