FIBROGENESIS

作品数：46被引量：605H指数：15
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相关领域：医药卫生更多>>
相关作者：陈志南边惠洁李浩吴佼更多>>
相关机构：第四军医大学同济大学上海中医药大学更多>>
相关期刊：《Journal of Bio-X Research》《World Journal of Gastroenterology》《肝脏》《Current Medical Science》更多>>
相关基金：国家自然科学基金河北省自然科学基金上海市教育委员会重点学科基金广西壮族自治区自然科学基金更多>>
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Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients被引量：4
《World Journal of Hepatology》2021年第2期218-232,共15页Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes 
the National Council for Science and Technology,No.SALUD-2016-272579 and No.PAPIIT-UNAM TA200515.
BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few s...
关键词：Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C FIBROGENESIS Fibrolysis 
Silencing ofα-complex protein-2 reverses alcohol-and cytokine-induced fibrogenesis in hepatic stellate cells被引量：2
《Liver Research》2017年第1期70-79,共10页Hao Liu Zhijin Chen Wei Jin Ashutosh Barve Yu-Jui Yvonne Wan Kun Cheng 
This work was supported by an award(1R01AA021510)from the National Institutes of Health.
Background and aim:a-complex protein-2(aCP2)encoded by the poly(rC)binding protein 2(PCBP2)gene is responsible for the accumulation of type I collagen in fibrotic livers.In this study,we silenced the PCBP2 gene using ...
关键词：Hepatic stellate cells Primary HSC MYOFIBROBLAST Liver fibrosis Poly(rC)binding protein(PCBP)2 Transforming growth factor(TGF)-b Platelet-derived growth factor(PDGF) Epidermal growth factor(EGF) LY2a09761 Migration 
An HNF 1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells被引量：16
《Cell Research》2015年第8期930-945,共16页Hui Qian Xing Deng Zhao-Wei Huang Ji Wei Chen-Hong Ding Ren-Xin Feng Xin Zeng Yue-Xiang Chen Jin Ding Lei Qiu Zhen-Lin Hu Xin Zhang Hong-Yang Wang Jun-Ping Zhang Wei-Fen Xie 
Acknowledgment We thank Dr Zhao-Hui Wei （TigerMed Co., Ltd., Shanghai, China） for assistance on statistical analysis. This work was supported by the National Natural Science Foundation of China （81470871 ; Key Program, 81230011; Creative Research Groups, 30921006） and Shanghai Science and Technology Committee for the Key Projects （13JC1407400）.
Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α（HNF1α） is a liver-enriched transcription factor that pla...
关键词：Hepatocyte nuclear factor 1α liver fibrosis SH2 domain-containing phosphatase-1 microRNA feedback CROSSTALK 
Angiogenesis and liver fibrosis被引量：26
《World Journal of Hepatology》2015年第3期377-391,共15页Gulsum Ozlem Elpek 
Recent data indicate that hepatic angiogenesis, regardless of the etiology, takes place in chronic liver diseases(CLDs) that are characterized by inflammat ion and progre s s ive f ibros is. B e c aus e ant iangiogeni...
关键词：Liver fibrosis ANGIOGENESIS CIRRHOSIS FIBROGENESIS Hepatic stellate cells Vascular endothelial growth factor HYPOXIA Chronic liver disease 
Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update被引量：91
《World Journal of Gastroenterology》2014年第23期7260-7276,共17页Gülsüm ?zlem Elpek 
There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis.Recent data indicate that the termination of fibrogenic processes...
关键词：Liver Liver fibrosis CIRRHOSIS FIBROGENESIS Hepatic stellate cells MYOFIBROBLAST Extracellular matrix 
Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha被引量：3
《World Journal of Gastroenterology》2006年第21期3338-3343,共6页Dariusz Marek Lebensztejn Maria Elzbieta Sobaniec-Lotowska Maciej Kaczmarski Michael Voelker Detlef Schuppan 
Supported by the Interdisciplinary Center for Clinical Research(IZKF) of the University of Erlangen-Nuernberg, Germany
To evaluate prospectively 4 selected serum fibrosis markers （tenascin, hyaluronan, collagen Ⅵ, TIMP-1） before, during and 12 mo after IFN treatment of children with chronic hepatitis B. METHODS： Forty-seven consec...
关键词：BIOPSY Collagen Ⅵ FIBROGENESIS Fibrosis Hepatitis B virus HYALURONAN Serum marker TENASCIN TIMP-1 
Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease被引量：21
《World Journal of Gastroenterology》2005年第4期476-481,共6页Yukiko Saitou Katsuya Shiraki Yutaka Yamanaka Yumi Yamaguchi Tomoyuki Kawakita Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano 
AIM: To evaluate the clinical utility of serum fibrosis markers, including YKL-40, in patients with HCV-associated liver disease. METHODS: A total of 109 patients with HCV-associated liver disease were enrolled. We me...
关键词：HCV Liver fibrosis YKL-40 INTERFERON 
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