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ELUCIDATION: 作品数：223被引量：331H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：毛江高毕思玮孔芳曾志李培欣更多>>; 相关机构：中国科学院福建物质结构研究所曲阜师范大学中国药科大学香港科技大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金北京市自然科学基金更多>>

Research progress in methods of acquisition,structure elucidation,and quality control of Chinese herbal polysaccharides: 《Chinese Journal of Natural Medicines》2025年第2期143-157,共15页Tingting Wang Baojie Zhu Jing Zhao Shaoping Li; supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP);the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117);the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。; The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...; 关键词：Chinese medicine POLYSACCHARIDE Extraction and purification Structural analysis Quality control

New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity: 《Chinese Journal of Natural Medicines》2024年第11期1003-1010,共8页WANG Mengru WANG Qi MA Yanzi ZEB Muhammad Aurang LI Xiaoli SHEN Feng XIAO Weilie; supported by the National Natural Science Foundation of China(Nos.22477108,82260682);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);the Scientific Research Fund of Yunnan Provincial Department ofEducation(No.2023Y0235)。; Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-me...; 关键词：Callicarpa integerrima Halimane diterpenes Clerodane diterpenes Structure elucidationanti-MRSA

Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis: 《Chinese Journal of Natural Medicines》2024年第7期643-653,共11页DANG Wen GUO Tingting ZHOU Di MENG Qingqi FANG Mingxia CHEN Gang LIN Bin HOU Yue LI Ning; supported by the National Natural Science Foundation of China(No.U1903122);the Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945);the Natural Science Foundation of Liaoning Province(No.2022-MS-242).; The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumar...; 关键词：Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity

Ten ring-B aromatized ergosterols from Aspergillus spectabilis: 《Chinese Journal of Natural Medicines》2024年第7期654-662,共9页WEI Mengsha SUN Weiguang LIU Linlin LI Yongqi LI Lanqin LI Qin CHEN Yu GUO Jieru GU Lianghu ZHU Hucheng CHEN Chunmei ZHANG Yonghui; supported by the National Key Research and Development Program of China(No.2021YFA0910500);the National Natural Science Foundation of China(No.U22A20380 and 82104043);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Science and Technology Major Project of Hubei Province(No.2021ACA012).; Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus spectabilis.Their structures and absolute configurations were determined using a combination of high-resolut...; 关键词：STEROIDS Aspergillus spectabilis Aromatic ergosterols Neuroprotective activities Structure elucidation

Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum: 《Chinese Journal of Natural Medicines》2024年第3期273-279,共7页DUAN Yulin SHI Zhengyi SONG Fei HOU Zhangrong TAN Xiaosheng ZHANG Yeting HAO Xincai CHEN Gang QI Changxing ZHANG Yonghui; supported by the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);the National Natural Science Foundation of China(Nos.82003633,32100321,and 32300335);the Research and Development Program of Hubei Province(No.2020BCA058);the Open Foundation of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(No.WDCM2022003);the National Natural Science Foundation of Hubei Province(No.2023AFB530);the Knowledge Innovation Project of Wuhan Science and Technology Bureau(No.2023020201020534).; Hyparillums A(1)and B(2),two previously unidentified polycyclic polyprenylated acylphloroglucinols(PPAPs)with intricate architectures,were isolated from Hypericum patulum Thunb.Hyparillum A was the first PPAP with eig...; 关键词：Polycyclic polyprenylated acylphloroglucinols Hypericum patulum Thunb. Immunosuppressive activities Structure elucidation.

β-Carboline alkaloids from the roots of Peganum harmala L.: 《Chinese Journal of Natural Medicines》2024年第2期171-177,共7页LI Shengge ZHANG Qin WANG Yuetong LIN Bin LI Dahong HUA Huiming HU Xu; supported by the National Natural Science Foundation of China(No.81773604);the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX09735005);the Doctoral Scientific Research Fund Project of Nanyang Institute of Technology(No.510197);the Interdisciplinary Sciences Project,Nanyang Institute of Technology(No.520097).; This study reports the isolation of four newβ-carboline alkaloids(1−4)and six previously identified alkaloids(5−10)from the roots of Peganum harmala L.Among these compounds,1 and 2 were characterized as rareβ-carbol...; 关键词：β-Carboline alkaloids Peganum harmala Structure elucidation Cytotoxic activity

Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii: 《Chinese Journal of Natural Medicines》2023年第6期443-453,共11页TAO Linlan XU Shuangyu ZHANG Zizhen LI Yanan YANG Jue GU Wei YI Ping HAO Xiaojiang YUAN Chunmao; supported by the National Natural Science Foundation of China(No.32270413,U1812403);the Science and Technology Department of Guizhou Province(No.QKH 2020-1Z076);the 13th batch of Outstanding Young Scientific and Technological Talents in Guizhou Province(No.QKHPTRC[2021]5633);Cultivation project of National Natural Science Foundation of Guizhou Medical University(No.19NSP003);the Education Department of Guizhou Province(No.QJH KY[2021]189);the Natural Science Foundation of Guizhou Province(No.QKHZYD[2022]4015);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);“Light of the West”Talent Cultivation Program of Chinese Academy of Sciences for Chunmao Yuan(No.RZ[2020]82).; This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic propert...; 关键词：Hypericum sampsonii Chemical constituents Structure elucidation Α-GLUCOSIDASE Molecular docking

Discovery of alkaloids from the leaves of Isatis indigotica Fortune with neuroprotective activity: 《Chinese Journal of Natural Medicines》2021年第9期680-685,共6页XI Yu-Fei LOU Li-Li HAN Feng-Ying WANG Xiao-Bo HUANG Xiao-Xiao YAO Guo-Dong SONG Shao-Jiang; supported by the National Natural Science Foundation of China(Nos.82003635 and 81973462);the Liaoning Revitalization Talents Program(No.XLYC2007180);the Program for Major Scientific and Medical Technology Problems of China Medicine Education Association in 2020(No.2020KTS003);the Natural Science Foundation of Liaoning Province of China(No.2019-MS-303);the Scientific Research Fund Project of Liaoning Provincial Department of Education(No.2019LJC05)。; Seven alkaloids including five undescribed ones(1 a/1 b,2,3 and 5)were obtained from the leaves of Isatis indigotica Fortune.Their structures were established by extensive spectroscopic analyses.The absolute configura...; 关键词：Isatis indigotica ALKALOIDS Neuroprotective effects Structure elucidation

Microbes as a production host to produce natural active compounds from mushrooms:biosynthetic pathway elucidation and metabolic engineering: 《Chinese Journal of Natural Medicines》2021年第8期580-590,共11页YANG Li-Yang GONG Qiang GUO Jian-Quan LI Gui-Lan; supported by the Key Research and Development Program for Science and Technology of Jinzhong(No.Y191021);the Basic Research Project of Shanxi University of Traditional Chinese Medicine(No.2020PY-JC(Y)-05);the Research Project Supported by Shanxi Scholarship Council of China(No.2020-132)。; Mushrooms are abundant in bioactive natural compounds.Due to strict growth conditions and long fermentation-time,microbe as a production host is an alternative and sustainable approach for the production of natural co...; 关键词：MUSHROOM Natural compound Microbes Synthetic biology Metabolic engineering

Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp.NF2410被引量：1: 《Chinese Journal of Natural Medicines》2020年第12期957-960,共4页LI Wei WEI Jing CHEN Dao-Ying WANG Mei-Jing SUN Yang JIAO Fang-Wen JIAO Rui-Hua TAN Ren-Xiang GE Hui-Ming; supported by the Ministry of Science and Technology(Nos.2018YFC1706200 and 2018YFA.902000);the National Natural Science Foundation of China(Nos.81925033,21861142005,81773591,21761142001,81673333,21661140001,and 91853109)。; Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp...; 关键词：Grasshopper-associated fungi Secondary metabolites Structure elucidation SHP2 Inhibitory activity

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