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Nucleic acid drugs:recent progress and future perspectives: 《Signal Transduction and Targeted Therapy》2024年第12期5610-5640,共31页Xiaoyi Sun Sarra Setrerrahmane Chencheng Li Jialiang Hu Hanmei Xu; supported by the National Natural Science Foundation of China(82373039);the University-Industry Collaboration Program(New Drug Targets and New Molecule Discovery and Technology 8210040001,2020-019)。; High efficacy,selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades.Currently,most clinically approved therapeutics are small molecules or protein/antibody biolo...; 关键词：DRUGS DISEASES typically

Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications: 《Signal Transduction and Targeted Therapy》2024年第12期5470-5512,共43页Yingying Shi Meixing Shi Yi Wang Jian You; supported by the National Key R&D Program of China(2023YFC340200);the National Natural Science Foundation of China(No.82404520,82273862);the China Postdoctoral Science Foundation(2024M752834);the China National Postdoctoral Program for Innovative Talents(BX20230321).; In the last decade,messenger ribonucleic acid(mRNA)-based drugs have gained great interest in both immunotherapy and nonimmunogenic applications.This surge in interest can be largely attributed to the demonstration of...; 关键词：DRUGS CLINICAL gained

Epigenetics-targeted drugs:current paradigms and future challenges: 《Signal Transduction and Targeted Therapy》2024年第12期5539-5609,共71页Wanlin Dai Xinbo Qiao Yuanyuan Fang Renhao Guo Peng Bai Shuang Liu Tingting Li Yutao Jiang Shuang Wei Zhijing Na Xue Xiao Da Li; supported by the National Natural Science Foundation grant of China(No.82371647,82071607,82071651,82403489);National Key Research and Development Program(2022YFC3600304,2022YFC2704700);Science and Technology Department of Sichuan Province(23ZDYF2489);Cadre Health Care Committee of Sichuan Province,China(2023-1701);Chengdu Science and Technology Bureau(2021-YF05-02106-SN,2017-GH02-00030-HZ);Outstanding Scientific Fund of Shengjing Hospital(No.202003);Sichuan University 0-1 Innovation Research project(2023SCUH0019);The Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(T FJC2023010001);China Postdoctoral Science Foundation(No.2023M733902,2023M743909);PHD Research Initiated Fund Project in Liaoning Province(No.2023-BSBA-331,2023-BSBA-352);Science and Technology Plan of Liaoning Province(2022JH2/20200066);345 Talent Project of Shengjing Hospital of China Medical University(No.M1344).; Epigenetics governs a chromatin state regulatory system through five key mechanisms:DNA modification,histone modification,RNA modification,chromatin remodeling,and non-coding RNA regulation.These mechanisms and their ...; 关键词：DRUGS TARGETED offering

Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy: 《Signal Transduction and Targeted Therapy》2024年第11期5200-5216,共17页Yu Xiao Tao Pan Wuren Da Yuanding Liu Shuangya Chen Daiquan Chen Keying Liu Yihan Zheng Daolong Xie Yuan Gao Haiyan Xu Yang Sun Weihong Tan; the China Postdoctoral Science Foundation(Certificate Number:2023M742348);the Fundamental Research Funds for the Central Universities(2020JCPT02);the“Innovation Research Team of High-Level of Local Universities in Shanghai”;the National Key Research and Development Program of China(2023YFC3405100).; Pancreatic cancer is one of the most malignant tumors with the highest mortality rates,and it currently lacks effective drugs.Aptamer-drug conjugates(ApDC),as a form of nucleic acid drug,show great potential in cancer...; 关键词：DRUGS SPECIFICITY SYNERGISTIC

Therapeutic interfering particles against HIV:molecular parasites reducing viremia: 《Signal Transduction and Targeted Therapy》2024年第11期4773-4775,共3页Henning Gruell Stanley Odidika Philipp Schommers; supported by the Emmy Noether Programme of the German Research Foundation(DFG,project no.495793173).; In a recent article in Science,Leon Weinberger and colleagues report on successful proof-of-concept studies of a novel strategy to control HIV-1 infection by using interfering viral particles.1 This approach radically...; 关键词：particles. DRUGS INHIBITING

Glucagon-like peptide-1 receptor: mechanisms and advances in therapy被引量：2: 《Signal Transduction and Targeted Therapy》2024年第10期4379-4407,共29页Zhikai Zheng Yao Zong Yiyang Ma Yucheng Tian Yidan Pang Changqing Zhang Junjie Gao; National Natural Science Foundation of China(82002339,81820108020);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System(BJ1-9000-22-4002).; The glucagon-like peptide-1(GLP-1)receptor,known as GLP-1R,is a vital component of the G protein-coupled receptor(GPCR)family and is found primarily on the surfaces of various cell types within the human body.This rec...; 关键词：DRUGS METABOLISM MECHANISMS

Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control: 《Signal Transduction and Targeted Therapy》2024年第10期4246-4313,共68页Shen Wang Wujian Li Zhenshan Wang Wanying Yang Entao Li Xianzhu Xia Feihu Yan Sandra Chiu; To adequately prepare for potential hazards caused by emerging and reemerging infectious diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future outbreaks and for which research ...; 关键词：PREVENTION EPIDEMIOLOGY DRUGS

Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2: 《Signal Transduction and Targeted Therapy》2024年第10期4600-4613,共14页Miao Zhu Fang Huang Huize Sun Kunpeng Liu Zhen Chen Baocheng Yu Haojie Hao Haizhou Liu Shuang Ding Xueyan Zhang Lishi Liu Kui Zhang Jierao Ren Yi Liu Haibin Liu Chao Shan Wuxiang Guan; National Natural Science Foundation of China[31970168];Hubei Science and Technology Major Project[2021ACB004];Key R&D Program of Hubei Province[2021BCD004];Hubei Central Leading Local Science and Technology Special Project[2022BGE245].; The various mutations in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pose a substantial challenge in mitigating the viral infectivity.The identification of novel host factors influencing SARS-CoV-2 repl...; 关键词：DRUGS URINE holds

Glycosylation:mechanisms,biological functions and clinical implications: 《Signal Transduction and Targeted Therapy》2024年第9期3615-3647,共33页Mengyuan He Xiangxiang Zhou Xin Wang; supported by National Natural Science Foundation(No.82270200,No.82170189,No.82070203,No.81800194,No.81770210);Key Research and Development Program of Shandong Province(No.2018CXGC1213);Taishan Scholars Program of Shandong Province(No.tspd20230610);China Postdoctoral Science Foundation(No.2021T1404223);Translational Research Grant of NCRCH(No.2021WWB02,No.2020ZKMB01);Shandong Provincial Natural Science Foundation(ZR2021YQ51);Shandong Provincial Engineering Research Center of Lymphoma;Academic Promotion Program of Shandong First Medical University(No.2019QL018).; Protein post-translational modification(PTM)is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups,and has a profound effect on prote...; 关键词：CLINICAL DRUGS RESIDUES

Drug tolerant persister cell plasticity in cancer:a revolutionary strategy for more effective anticancer therapies: 《Signal Transduction and Targeted Therapy》2024年第9期3816-3839,共24页Jun He Zejing Qiu Jingjing Fan Xiaohong Xie Qinsong Sheng Xinbing Sui; Non-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance.Among these,the drug tolerant persister(DTP)cell phenotype is attracting more and more attention and giving a predominant...; 关键词：DRUGS attracting TOLERANT

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