Supported by Recurrent Grants from Institut National de la Santéet de la Recherche Médicale to the INSERM U1048.
BACKGROUND Despite overt insulin resistance,adipocytes of genetically obese Zucker rats accumulate the excess of calorie intake in the form of lipids.AIM To investigate whether factors can replace or reinforce insulin...
The Background: Tramadol, is a central acting analgesic that possesses weak affinity for the μ-opioid receptor and modifies transmission of nociceptive impulses through inhibition of monoamine reuptake. This study wa...
Supported by Post-doctoral Scientific Research of Heilongjiang Province (LBH-Q07016)
The aim of this experiment was to determine the pharmacokinetics of hydrochloric idazoxan in deers plasma alter intramuscular (IM) dosing. Six clinical healthy Cervus nippon Temmincks were injected with the idazoxan...
The nature of the binding site(s) involved in the insulin secretory activity of imidazoline compo- unds remains unclear. An imidazoline I2 binding site (I2BS) has been neglected since the classic I2 ligand, idazoxan, ...
Supported by the National Natural Science Foundation of China (No 39970845);Beijing Natural Science Foundation (No 7992028)
AIM: To study the regulation of monoamine oxidase-B (MAO-B) activity and imidazoline receptors (I-R) during long term treatment of morphine. METHODS: MAO-B activity was detected by high performance liquid chromatograp...
AIM: To study the effect of agmatine (Agin) on carotid sinus baroreflex. METHODS: The functional parameters of baroreflex were measured by perfusing the carotid sinus in anesthetized rats. RESULTS: (1) Agm 1,5, and 10...
Supported by the National Natural Science Foundation of China, No 39970845;Beijing Natural Science Foundation, No 7992028.
AIM: To study the influence of idazoxan (Ida), an an tagonist of imidazoline receptors (I-R), on analgesia, tolerance, and physical dependence of morphine. METHODS: The effects of Ida on pain threshold and morphine an...
<正> We compared the ability of α2-adrenoceptor antagonists idazoxan (Ida), yohimbine (Yoh) and a cholinesterase inhibitor 5-(1,3,3-trimethylindoline) N,N dimethyl carbamate hydrochloride (TM...