IDAZOXAN

作品数:10被引量:2H指数:1
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相关领域:医药卫生更多>>
相关作者:苏瑞斌李锦何瑞荣陈日新张林更多>>
相关机构:北京药理毒理研究所南京铁道医学院第三军医大学天津医科大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《东南大学学报(医学版)》《Open Journal of Anesthesiology》《四川生理科学杂志》更多>>
相关基金:北京市自然科学基金国家自然科学基金更多>>
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Increased monoamine oxidase activity and imidazoline binding sites in insulin-resistant adipocytes from obese Zucker rats
《World Journal of Biological Chemistry》2022年第1期15-34,共20页Christian Carpéné Luc Marti Nathalie Morin 
Supported by Recurrent Grants from Institut National de la Santéet de la Recherche Médicale to the INSERM U1048.
BACKGROUND Despite overt insulin resistance,adipocytes of genetically obese Zucker rats accumulate the excess of calorie intake in the form of lipids.AIM To investigate whether factors can replace or reinforce insulin...
关键词:Obesity ADIPOCYTE Amine oxidases Imidazoline binding sites Creatine kinase B IDAZOXAN LIPOGENESIS Hydrogen peroxide Glucose uptake 
The Effect of Tramadol on Blood Glucose Levels in Rats
《Open Journal of Anesthesiology》2013年第1期18-22,共5页Hacer Kara Ayse Karci Mukaddes Gumustekin Murat Ormen Aydin Tasdogen Zahide Elar 
The Background: Tramadol, is a central acting analgesic that possesses weak affinity for the μ-opioid receptor and modifies transmission of nociceptive impulses through inhibition of monoamine reuptake. This study wa...
关键词:HYPERGLYCEMIA TRAMADOL a2Antagonist Antinociceptive Effect YOHIMBINE IDAZOXAN RAT 
Pharmacokinetics of Idazoxan in Deers Following Intramuscular Administration
《Journal of Northeast Agricultural University(English Edition)》2011年第3期28-32,共5页YIN Baishuang GAO Li WANG Hongbin HA Da 
Supported by Post-doctoral Scientific Research of Heilongjiang Province (LBH-Q07016)
The aim of this experiment was to determine the pharmacokinetics of hydrochloric idazoxan in deers plasma alter intramuscular (IM) dosing. Six clinical healthy Cervus nippon Temmincks were injected with the idazoxan...
关键词:IDAZOXAN PHARMACOKINETIC DEER 
Comparative effects of idazoxan, efaroxan, and BU 224 on insulin secretion in the rabbit: Not only interaction with pancreatic imidazoline I2 binding sites
《Health》2010年第2期112-123,共12页María José García-Barrado María Francisca Pastor María Carmen Iglesias-Osma Christian Carpéné Julio Moratinos 
The nature of the binding site(s) involved in the insulin secretory activity of imidazoline compo- unds remains unclear. An imidazoline I2 binding site (I2BS) has been neglected since the classic I2 ligand, idazoxan, ...
关键词:BU 224 EFAROXAN IDAZOXAN IMIDAZOLINE Ligands Insulin Secretion IVGTT (Intravenous Glucose Tolerance Test) KATP Channel PK Activity RABBIT PANCREATIC Islets 
Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine被引量:1
《Acta Pharmacologica Sinica》2001年第7期639-644,共6页苏瑞斌 李锦 李昕 秦伯益 
Supported by the National Natural Science Foundation of China (No 39970845);Beijing Natural Science Foundation (No 7992028)
AIM: To study the regulation of monoamine oxidase-B (MAO-B) activity and imidazoline receptors (I-R) during long term treatment of morphine. METHODS: MAO-B activity was detected by high performance liquid chromatograp...
关键词:MORPHINE monoamine oxidase: idazoxan AGMATINE 
Agmatine inhibits carotid sinus baroreflex in anesthetized rats
《Acta Pharmacologica Sinica》2001年第3期74-78,共5页秦晓梅 何瑞荣 
AIM: To study the effect of agmatine (Agin) on carotid sinus baroreflex. METHODS: The functional parameters of baroreflex were measured by perfusing the carotid sinus in anesthetized rats. RESULTS: (1) Agm 1,5, and 10...
关键词:AGMATINE carotid sinus BAROREFLEX blood pressure imidazoline receptors alpha-2 adrenergic receptors IDAZOXAN 
Influence of idazoxan on analgesia, tolerance, and physical dependence of morphine in mice and rats in vivo被引量:1
《Acta Pharmacologica Sinica》2000年第11期53-57,共5页苏瑞斌 李锦 高凯 裴钢 秦伯益 
Supported by the National Natural Science Foundation of China, No 39970845;Beijing Natural Science Foundation, No 7992028.
AIM: To study the influence of idazoxan (Ida), an an tagonist of imidazoline receptors (I-R), on analgesia, tolerance, and physical dependence of morphine. METHODS: The effects of Ida on pain threshold and morphine an...
关键词:IDAZOXAN AGMATINE MORPHINE imida-zoline receptors morphine dependence 
利美尼定的药理作用研究进展
《四川生理科学杂志》1998年第2期27-30,共4页魏斌 张敏 
利美尼定是恶唑啉的衍生物,作为第二代中柩性抗高血压药的代表,1987年开始应用于法国。以前认为,利美尼定是通过激动延髓孤束核的α2肾上腺素受体降低外周交感活性而降低血压,但最近几年越来越多的研究证实,利美尼定通过作...
关键词:利美尼定 咪唑啉受体 药理作用研究 可乐定 IDAZOXAN 脑梗塞 抗心律失常作用 星形细胞 细胞死亡 神经保护作用 
Antagonism of xylazine-ketamine anesthesia by idazoxan, yohimbine and 5-(1,3,3-trimethylindoline) N,N-dimethylcarbamate in dogs
《中国药理学与毒理学杂志》1991年第4期245-245,共页
<正> We compared the ability of α2-adrenoceptor antagonists idazoxan (Ida), yohimbine (Yoh) and a cholinesterase inhibitor 5-(1,3,3-trimethylindoline) N,N dimethyl carbamate hydrochloride (TM...
实验性高血压犬交感神经末梢去甲肾上腺素的释放调节
《东南大学学报(医学版)》1990年第1期12-16,共5页徐标 陈日新 陈达光 张林 粟建明 
肾性高血压和正常犬股动脉内注入可卡因阻断突触前去甲肾上腺素(NE)的回摄取,注入酪胺促进交感神经末梢释放NE,观察α_1和α_2受体阻断前后NE分泌率和灌流压的变化。结果显示,酪胺促进NE释放后高血压犬NE分泌率较正常犬高,这是由于高血...
关键词:肾性高血压 肾上腺素能受体 股动脉 去甲肾上腺素 哌唑嗪 IDAZOXAN 酪胺 可卡因 
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