CYNOMOLGUS

作品数：10被引量：25H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：任振华更多>>
相关机构：首都医科大学昆明理工大学更多>>
相关期刊：《Science China(Life Sciences)》《Chinese Medical Journal》《The Innovation》《Open Journal of Animal Sciences》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies
《The Innovation》2023年第3期104-111,共8页Zongyang Lu Jie Li Yong Lu Ling Li Wei Wang Chenchen Zhang Libing Xu Yanhong Nie Changshan Gao Xinyan Bian Zhen Liu Guang-Zhong Wang Qiang Sun 
supported by the National Key Research and Development Program of China(2022YFF0710901 to Q.S.);the National Natural Science Foundation of China(grants 31825018 and 82021001 toQ.S.;81827901 and 32170567 toG.W.);the ShanghaiMunicipal Science and Technology Major Project(2018SHZDZX05 to Q.S.and Z.Liu);the Biological Resources Program of the Chinese Academy of Sciences(KFJ-BRP-005);the Strategic Priority Research Programof the Chinese Academy of Sciences(XDB32060000 to Q.S.and Z.Liu);the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences From 0 to 1 original innovation project(ZDBS-LY-SM019 to Z.Liu);the China National Postdoctoral Program for Innovative Talents(BX20200350 to Z.Lu).
Genomic imprinting can lead to allele-specific expression(ASE),where one allele is preferentially expressed more than the other.Perturbations in genomic imprinting or ASE genes have been widely observed across various...
关键词：IMPRINTING ALLELE CHROMOSOMAL 
PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys被引量：6
《Zoological Research》2021年第4期469-477,共9页Zhen-Zhen Chen Jian-Ying Wang Yu Kang Qiao-Yan Yang Xue-Ying Gu Da-Long Zhi Li Yan Cheng-Zu Long Bin Shen Yu-Yu Niu 
supported by the National Key Research and Development Program(2016YFA0101401 and 2018YFA0801400);Major Basic Research Project of Science and Technology of Yunnan(2019FY002 and 202001BC070001)。
Mutations of PTEN-induced kinase I(PINK1)cause early-onset Parkinson’s disease(PD)with selective neurodegeneration in humans.However,current PINK1 knockout mouse and pig models are unable to recapitulate the typical ...
关键词：Cas9-D10A CYNOMOLGUS PINK1 
Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs被引量：7
《Protein & Cell》2020年第2期97-107,共11页Rui Fu Dawei Yu Jilong Ren Chongyang Li Jing Wang Guihai Feng Xuepeng Wang Haifeng Wan Tianda Li Libin Wang Ying Zhang Tang Hai Wei Li Qi Zhou 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030400 to W.L.);the National Key Research and Development Program(2016YFA0100202 and 2017YFA0104401 to T.H.,2018YFA0109701 to R.F.);the National Natural Science Foundation of China(31621004 to Q.Z.and W.L.,31571533 to H.W.,and 31701286 to G.F.);the Key Research Projects of the Frontier Science of the Chinese Academy of Sciences(QYZDY-SSWSMC002 to Q.Z.).
Blastocyst complementation by pluripotent stem cell(PSC)injection is believed to be the most promising method to generate xenogeneic organs.However,ethical issues prevent the study of human chimeras in the late embryo...
关键词：embryonic stem cells blastocyst COMPLEMENTATION CYNOMOLGUS monkey pig INTERSPECIES CHIMERA organ reconstruction 
Depressed female cynomolgus monkeys(Macaca fascicularis) display a higher second-to-fourth(2D:4D)digit ratio
《Zoological Research》2019年第3期219-225,共7页Wei Li Ling-Yun Luo Xun Yang Yong He Bin Lian Chao-Hua Qu Qing-Yuan Wu Jian-Guo Zhang Peng Xie 
supported by the National Natural Science Foundation of China(816 01207);National Basic Research Program of China(973 Program)(2017YFA 0505700)
This research aimed to provide evidenee of a relationship between digit ratio and depression status in the cynomolgus monkey(Macaca fascicularis).In stable cyno molgus mon key social groups,we selected 15 depressed mo...
关键词：Fin ger length DIGIT ratio Major DEPRESSIVE disorder CYNOMOLGUS MON key 
Metagenomic comparison of the rectal microbiota between rhesus macaques(Macaca mulatta) and cynomolgus macaques(Macaca fascicularis)被引量：2
《Zoological Research》2019年第2期89-93,共5页Yan-Fang Cui Feng-Jie Wang Lei Yu Hua-Hu Ye Gui-Bo Yang 
supported by the National Natural Science Foundation of China(81571607);Beijing Natural Science Foundation(7162136);Ministry of Science and Technology(2017ZX10202102003005,2015BAI08B03)of China
Rhesus macaques(Macaca mulatta) and cynomolgus macaques(Macaca fascicularis) are frequently used in establishing animal models for human diseases. To determine the differences in gut microbiota between these species, ...
关键词：RHESUS MACAQUES CYNOMOLGUS MACAQUES Gut MICROBIOTA Next generation sequencing 
Comparison of gene expression in cynomolgus monkeys with preclinical type Ⅱ diabetes induced by different high energy diets被引量：1
《Animal Models and Experimental Medicine》2019年第1期44-50,共7页Li-Sha Jin Jun-Hua Rao Li-Biao Zhang Fang Ji Yan-Chun Zhang Xiang-Fen Hao Bai-Lu Peng Xiao-Ming Liu Yun-Xiao Sun 
Science and Technology Planning Project of Guangdong Province,Grant/Award Number:2016A030303037 and 2017A070702014;Natural Science Foundation of Guangdong Province,(2018A030313307);National Natural Science Foundation of China,Grant/Award Number:81102358;GDAS Special Project of Science and Technology Development,Grant/Award Number:2017GDASCX-0107
Background : Cynomolgus disease models that are similar to the preclinical stage of human type 2 diabetes mellitus(T2 DM) were established by feeding middle-aged cynomolgus monkeys different high energy diets to study...
关键词：CYNOMOLGUS MONKEY gene expression high energy diet PRECLINICAL phase TYPE 2 DIABETES 
Morphological evaluation of retinal ganglion cells expressing the L132C/T159C ChR2 mutant transgene in young adult cynomolgus monkeys被引量：2
《Science China(Life Sciences)》2017年第11期1157-1167,共11页Wenyao Wang Yan Nan Zhuo-Hua Pan Mingliang Pu 
supported by National Science Foundation of China(31571091 to Mingliang Pu),National Basic Research Program of China (2015CB351806 to Mingliang Pu);National Institutes of Health Grant (NIH) (EY17130 to Zhuo-Hua Pan);Dryer Foundation, the Ligon Research Center of Vision, and Research to Prevent Blindness to Department of Ophthalmology at Wayne State University
To characterize recombinant AAV2 （rAAV2）-mediated expression of L 132C/T 159C ChR2 mutant in retinal ganglion cells （RGCs） of young adult cynomolgus monkeys, rAAV2 vectors carrying a fusion construct of the ChR2 m...
关键词：ChR2 mutant transgene retinal ganglion cells cynomolgus monkey 
Effect of Alemtuzumab on Intestinal Intraepithelial Lymphocytes and Intestinal Barrier Function in Cynomolgus Model被引量：4
《Chinese Medical Journal》2015年第5期680-686,共7页Lin-Lin Qu Ya-Qing Lyu Hai-Tao Jiang Ting Shan Jing-Bin Zhang Qiu-Rong Li Jie-Shou Li 
This work was supported by grants from the National Basic Research Program （973 Program） in China （No. 2007CB513005 and 2009CB522405）, Shangdong Province Young and Middle-Aged Scientists Research Awards Fund （No. BS2011YY004）, the Key Project of National Natural Science Foundation in China （No. 30830098）, National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science and Technology of China （No. 2008BAI60B06）, the National Natural Science Foundation in China （No. 3067206t）, the Military Scientitle Research Fund （No. 0603AM 117） and the Gut Barrier Foundation of Jie-Shou Li Academician.
Background：Alemtuzumab has been used in organ transplantation and a variety of hematologic malignancies （especially for the treatment of B-cell chronic lymphocytic leukemia）.However,serious infectious complications...
关键词：ALEMTUZUMAB Barrier Function INFECTION Intestinal lntraepithelial Lymphocytes Lymphocyte Depletion 
Effects of Fasting on Plasma Lipoprotein(a) in Cynomolgus Monkeys: Preliminary Experiments Results
《Open Journal of Animal Sciences》2014年第5期222-227,共6页Masataka Kusunoki Kazuhiko Tsutsumi Daisuke Sato Tetsuro Miyata Takao Nakamura 
Plasma lipoprotein(a) (Lp(a)) is known to be a strong independent risk factor for ischemic heart disease. However, it is not easily modulated by drugs that are presently available. Lp(a) is not present in many experim...
关键词：Lipoprotein(a) FASTING CYNOMOLGUS MONKEY BANANA 
Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys被引量：3
《Science China(Life Sciences)》2010年第5期563-572,共10页ZHANG Y.Alex 
supported in part by the National High Technology Research and Development Program of China (Grant No 2006AA02A114);the Science Project of Beijing Municipal Science Technology Commission (Grant No D07050701350703)
Bone marrow mesenchymal stem cells(BM-MSCs) are a potential tool for cell therapy and tissue engineering.In this study,we carried on a comparative study of the characteristics of MSCs from different age cynomolgus mon...
关键词：CYNOMOLGUS MONKEY MESENCHYMAL stem cells DIFFERENTIATION EXPANSION safety 
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