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DIOSCIN: 作品数：10被引量：45H指数：4; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：朱庆国李涛孟强刘克辛邹传纯更多>>; 相关机构：中国科学院福建省立医院合肥工业大学昆明医科大学更多>>; 相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Food Science and Human Wellness》《Chinese Herbal Medicines》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金更多>>

Impact and mechanism study of dioscin on biological characteristics of colorectal cancer cells: 《World Journal of Gastrointestinal Oncology》2024年第11期4456-4467,共12页Xie-Xiao Cai Zhen-Feng Huang Fu-Yang Tu Jie Yu; BACKGROUND Colorectal cancer(CRC)is a considerable global health issue.Dioscin,a compound found in several medicinal plants,has shown potential anticancer effects.AIM To find the relationship between CRC cells(HCT116)...; 关键词：DIOSCIN Colorectal cancer NOTCH1 Cell apoptosis Cell proliferation

Dioscin from Polygonatum sibiricum induces apoptosis and autophagy in Ishikawa human endometrial cancer cell and in vivo: 《Food Science and Human Wellness》2024年第5期2601-2616,共16页Xiaoli Li Runhui Ma Zhijing Ni Wei Wang Kiran Thakur Jianguo Zhang Zhaojun Wei; supported by the National Key Research&Development Program of China(2022YFF1100305);the National Natural Science Foundation of Ningxia Province(2021AAC02019,2022AAC03230);the Key research and development projects in Ningxia province(2021BEF02013).; With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural charact...; 关键词：DIOSCIN Ishikawa cell APOPTOSIS AUTOPHAGY PI3K/AKT p53

Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling被引量：3: 《Journal of Pharmaceutical Analysis》2023年第10期1153-1167,共15页Zhang Mao Haochen Hui Xuerong Zhao Lina Xu Yan Qi Lianhong Yin Liping Qu Lan Han Jinyong Peng; funding from the Spring City Plan:The High-Level Talent Promotion and Training Project of Kunming and the Independent Research Fund of Yunnan Characteristic Plant Extraction Laboratory(Grant No.:2022YKZY001).; It is necessary to explore potent therapeutic agents via regulating gut microbiota and metabolism to combat Parkinson's disease(PD).Dioscin,a bioactive steroidal saponin,shows various activities.However,its effects an...; 关键词：Parkinson's disease DIOSCIN Gut microbiota Bile acid metabolism GLP-1

Protective effects of Dioscin on TNF-α-induced collagen-induced arthritis rat fibroblast-like synoviocytes involves in regulating the LTB4/BLT pathway: 《BIOCELL》2021年第4期1005-1012,共8页ZHIPING WEI YAJUN LIU MEIWEN YANG MENGDI LI KEXIN LI LUXI ZHENG HUIQIONG GUO FENFANG HONG SHULONG YANG; supported by the National Natural Science Foundation of China(Nos.82060661,81660751,81660151);Jiangxi Provincial Natural Science Foundation of China(No.20171BAB205085).; Background and Objective:LTB4 has been shown to be involved in rheumatoid arthritis(RA)pathogenesis.The effect of Dioscin(Dio)on the LTB4 pathway of RA have not been reported yet.This study aimed at further exploring ...; 关键词：Rheumatoid arthritis DIOSCIN Fibroblast-like synoviocytes Leukotriene B4 LTA4 hydrolase Leukotriene B4 receptor

Neuroprotective effect of dioscin on cerebral ischemia/reperfusion mice by reducing glial cell activation and maintaining the levels of SODs被引量：6: 《Journal of Chinese Pharmaceutical Sciences》2017年第9期684-691,共8页Cheng Yin Jie Wang Pei Xu Bingchun Yan; The National Natural Science Foundation of China(Grant No.81401005);the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20140494);the College Students’Practice Innovation Training Program Projects of Jiangsu Province(Grant No.201611117094X); In the present study, we aimed to explore the neuroprotective effect of dioscin, a natural steroid saponin, on transient focal cerebral ischemia induced by middle cerebral artery occlusion （MCAO） in mice and its rel...; 关键词：DIOSCIN GLIOSIS ANTIOXIDANT NEUROPROTECTION Cerebral ischemia/reperfusion

Dioscin-induced Apoptosis of Human LNCaP Prostate Carcinoma Cells through Activation of Caspase-3 and Modulation of Bcl-2 Protein Family被引量：17: 《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第1期125-130,共6页陈静李辉敏张学农熊朝梅阮金兰; supported by the National Natural Science Foundation of China(No.81173065); Dioscin is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. In the present study, we investigated the anti-cancer activity of dioscin agai...; 关键词：DIOSCIN LNCAP ANTI-TUMOR apoptosis pathway capsase-3 Bcl-2 protein family

Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells被引量：12: 《World Journal of Gastroenterology》2011年第39期4389-4395,共7页Lin-Lin Gao Fu-Rong Li Peng Jiao Ming-Feng Yang Xiao-Jun Zhou Yan-Hong Si Wen-Jian Jiang Ting-Ting Zheng; Supported by The grant from the Department of Education of Shandong Province,China,No.J10LF18; AIM:To investigate the anti-tumor effects of Paris chinensis dioscin(PCD)and mechanisms regarding cell cycle regulation and apoptosis in human gastric cancer SGC-7901 cells.METHODS:Cell viability was analyzed by the 3...; 关键词：CyclinB1/CDK1 Cell cycle arrest Caspase-3 Ca2＋ Cytochrome C

Simultaneous Determination of Four Major Steroidal Saponins in seven species of Dioscorea L.By HPLC-ELSD被引量：1: 《Chinese Herbal Medicines》2011年第1期-,共5页; Objective To control the quality of the species in Dioscorea L.better.Methods An HPLC-ELSD method was developed for the first time to simultaneously determine four bioactive ingredients:dioscin,gracillin,protoneodiosc...; 关键词：DIOSCIN Dioscorea L. gracillin HPLC-ELSD protoneodioscin protoneogracillin

The Synthesis of Gracillin and Dioscin: Two Typical Representatives of Spirostanol Glycosides被引量：6: 《Chinese Chemical Letters》2003年第4期361-364,共4页Chuan Chun ZOU Shu Jie HOU Ping Sheng LEI Xiao Tian LIANG; Two spirostanol saponins (gracillin and dioscin) which have the typical sugar moieties were synthesized facilely by a general approach.; 关键词：Spirostanol glycosides GLYCOSYLATION cadmium carbonate.

Effects of Dioscin Extracted from Polygonatum Zanlanscianense Pamp on Several Human Tumor Cell Lines被引量：1: 《Tsinghua Science and Technology》2001年第3期239-242,共4页王钊周江兵巨勇姚沈勤张洪钧; partly by the Tsinghua U niversity- HongKong Baptist U niversity Joint Institute for Research ofChinese Medicine ; the" 985" Fund fromTsinghua U niversity.; Dioscin was extracted and isolated from Polygonatum Zanlanscianense Pamp. The effects of dioscin on HL60, HeLa, H14, and MDA MB 435 cell lines were studied with the results showing that dioscin dramatically inhibite...; 关键词：Thiazolyl blue (MTT) Polygonatum Zanlanscianense Pamp DIOSCIN

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