REPEATS

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Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第2期76-93,共18页Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei 
Supported by National Natural Science Foundation of China,No.82160762;Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230267;China Undergraduate Innovation and Entrepreneurship Training Program,No.S202410598060X;China Undergraduate Innovation and Entrepreneurship Training Program,No.X202410598360;Future Academic Star of Guangxi Medical University,No.WLXSZX24074.
BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on th...
关键词：Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing 
Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing
《Nano Research》2024年第10期8904-8925,共22页Zhongyuan Guo Audrey T.Zhu Ronnie H.Fang Liangfang Zhang 
supported by the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense(No.HDTRA1-21-1-0010);the National Institutes of Health(Nos.R21AI159492,and R21AI175904).
The continued development of clustered regularly interspaced short palindromic repeats(CRISPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and treatment.Despite h...
关键词：clustered regularly interspaced short palindromic repeats(CRISPR) in vivo gene editing NANOCARRIERS recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP) 
The Applications of CRISPR Screening in Aging Research
《中国生物化学与分子生物学报》2024年第9期1186-1196,共11页XU Jia-Xin JING Yao-Bin QU Jing LIU Guang-Hui 
国家自然科学基金项目(No.81921006,92149301,92168201,82330044,32341001);国家重点研发计划项目(No.2020YFA0804000,2020YFA0112200);中国科学院稳定支持基础研究领域青年团队计划(No.YSBR-076)和新基石科学基金会“科学探索奖”(No.2021-1045)海南省科技厅重点研发项目(No.2023ICAC-YANFA);海南省科技厅科技平台建设项目(No.2023ICAC-YUNXING)资助。
The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into ...
关键词：Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) genetic screening AGING 
Boosting CAR-T cell therapy with CRISPR technology
《hLife》2024年第8期380-396,共17页Liyanran Yan Shanzi Gao Xinhui Wang Xintao Zhou Praopim Limsakul Yiqian Wu 
supported by Peking University the Fundamental Research Funds for the Central Universities(7101303078).
Chimeric antigen receptor(CAR)-T cell therapy has made remarkable breakthroughs in treating cancers,especially hematologic malignancies,yet its broader application in cancer treatment is hindered by multiple challenge...
关键词：chimeric antigen receptor(CAR)-T cell therapy clustered regularly interspaced short palindromic repeats(CRISPR) IMMUNOTHERAPY 
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction
《Acta Pharmaceutica Sinica B》2024年第5期2026-2038,共13页Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun Nana Wang Yang Chen Chunsheng Dong Kin Yip Tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying 
This work was supported by the National Natural Science Foundation of China(Nos.82022022,32371018 and 82071274);a Project Funded by Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003,China);a Key Project of Natural Science Foundation of Jiangsu Provincial Higher Education Institutions(23KJA310005,China);a Project Funded by the Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University(MP13202823,China);a Project Funded by the Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and a Project Funded by the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD).J.H.M.P.was supported Science Foundation Ireland(17/COEN/3474,17/JPND/3455);Q.M.is a recipient of an RCSI International StAR Ph.D.scholarship.N.L.was supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province.K.Y.T.,was supported by the financial support from the Science and Technology Development Fund,Macao SAR(File no.0062/2021/A,China);University of Macao(File no.MYRG2022-00171-FHS,China).
Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative disorders.The GGGGCC·GGCCCC...
关键词：Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 AUTOPHAGY BCL2 BECN1/Beclin 1 Dipeptide repeat Neurodegeneration 
DNA Tandem Repeats as Iterable Objects to Count Cell Divisions: A Computational Model
《Advances in Bioscience and Biotechnology》2024年第4期207-234,共28页Marco Franco Giulio Regolini 
Cell lineages of nematodes are completely known: the adult male of Caenorhabditis elegans contains 1031 somatic cells, the hermaphrodite 959, not one more, not one less;cell divisions are strictly deterministic (as in...
关键词：Satellite DNA Tandem-Repeats EPIGENETICS 
Genetic resources and precise gene editing for targeted improvement of barley abiotic stress tolerance
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第12期1069-1092,共24页Sakura KARUNARATHNE Esther WALKER Darshan SHARMA Chengdao LI Yong HAN 
Abiotic stresses, predominately drought, heat, salinity, cold, and waterlogging, adversely affect cereal crops. They limit barley production worldwide and cause huge economic losses. In barley, functional genes under ...
关键词：Clustered regularly interspaced short palindromic repeats(CRISPR) Gene function DROUGHT Genetic improvement Transcription regulation Breeding 
Targeting KRAS in pancreatic adenocarcinoma:Progress in demystifying the holy grail
《World Journal of Clinical Oncology》2023年第8期285-296,共12页Ahmed Elhariri Ahmed Alhaj Daniel Ahn Mohamad Bassam Sonbol Tanios Bekaii-Saab Christina Wu Michael Scott Rutenberg John Stauffer Jason Starr Umair Majeed Jeremy Jones Mitesh Borad Hani Babiker 
Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an importan...
关键词：Kirsten rat sarcoma virus Targeted therapy Pancreatic cancer Drug resistance Next generation sequencing Clustered regularly interspaced short palindromic repeats 
CRISPR/Cas systems for the detection of nucleic acid and nonnucleic acid targets被引量：6
《Nano Research》2023年第7期9940-9953,共14页Weiran Su Junru Li Chen Ji Congshuo Chen Yuzheng Wang Huili Dai Fengqin Li Peifeng Liu 
This work was financially supported by the National Natural Science Foundation of China(Nos.81771968 and 22204104);the Shanghai Sailing Program(No.21YF1444900);the Shanghai Municipal Natural Science Foundation(No.22ZR1459600);the Medical-Engineering Joint Funds from the Shanghai Jiao Tong University(Nos.YG2023ZD07 and YG2021QN23);the Foundation of Shanghai Municipal Health Commission(No.2022JC002);the Innovative Research Team of High-Level Local Universities in Shanghai,China.
Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)systems are becoming powerful tools for disease biomarkers detection.Due to the specific recognition,cis-cleavage and nonspecific...
关键词：clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) DETECTION nucleic acid targets non-nucleic acid targets 
NOTCH2NLC expanded GGC repeats in patients with cerebral small vessel disease被引量：1
《Stroke & Vascular Neurology》2023年第2期161-168,共8页Yun-chao Wang Yu Fan Wen-Kai Yu Si Shen Jia-Di Li Yuan Gao Yan Ji Yu-Sheng Li Lu-Lu Yu Zi-Chen Zhao Shan-Shan Li Yao Ding Chang-He Shi Yu-ming Xu 
supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[grant number 2020-PT310-01];the National Natural Science Foundation of China to Dr.Chang-he Shi[grant number 82171247,81974211];the National Natural Science Foundation of China to Dr.Yu-ming Xu[grant numbers U1904207].
Objective GGC repeat expansions in the human-specific NOTCH2NLC gene have been reported as the cause of neuronal intranuclear inclusion disease(NIID).Given the clinical overlap of cognitive impairment in NIID and cere...
关键词：PATIENTS CEREBRAL expanded 
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