云南高校图书馆联盟文献共享服务平台- METABOLOMIC

METABOLOMIC: 作品数：175被引量：496H指数：12; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张哲毕惠嫦杨宇卓赵一懿傅欣彤更多>>; 相关机构：中山大学北京大学第三医院北京市药品检验所华中农业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金高等学校学科创新引智计划中国博士后科学基金上海市自然科学基金更多>>

Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism: 《World Journal of Diabetes》2025年第5期331-345,共15页Zhong-Yong Zhang Yu-Ming Wang Ning Wang Yuan-Song Wang Hui Zhang Duo Wang Li-Xin Wang Huan-Tian Cui Wei-Bo Wen Shu-Quan Lv Yong-Jun Cao; Supported by the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program,No.H2020110287;Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province,No.7[2024];Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.3[2024];Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,No.SZX2020015;Jiangsu Province Chinese Medicine Science and Technology Development Program Project,No.YB2020065.; BACKGROUND Diabetic nephropathy(DN)is a major complication of diabetes,marked by progressive renal damage and an inflammatory response.Although research has investigated the pathological mechanisms underlying DN,effec...; 关键词：Diabetic nephropathy Shenzhuo formulation TRANSCRIPTOMIC METABOLOMIC Cytochrome P450 Arachidonic acid metabolic INFLAMMATORY Oxidative stress

Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis: 《Science China(Life Sciences)》2025年第4期1042-1056,共15页Jinzhou Feng Shi Tang Xiaolin Yang Mengjie Zhang Zhizhong Li Shaoru Zhang Yongliang Han Yongmei Li Philippe P.Monnier Gang Yu Peng Zheng Cunjin Zhang Ke Xu Xinyue Qin; supported by the National Science Foundation of China (81701191, 82301720);Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0973, CSTB2023NSCQMSX0183, CSTB2023NSCQ-BHX0214);China Postdoctoral Science Foundation (2022M722384, 2023MD734128);the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2020FYYX104);Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010);Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214);the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310);CQMU Program for Youth Innovation in Future Medicine (W0168)。; Although disturbances in the gut microbiome have been implicated in multiple sclerosis(MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes aff...; 关键词：relapsing remitting multiple sclerosis gut microbiota 16S rRNA gene sequence untargeted metabolomics lipid metabolism biomarker

Metabolomic profiling and prognostication in CoVID-19 acute respiratory distress syndrome: 《Journal of Intensive Medicine》2025年第1期108-110,共3页David Furfaro Xiaoyu Che Wenhao Gou Matthew J.Cummings Nischay Mishra Daniel Brodie Thomas Briese Oliver Fiehn W.Ian Lipkin Max R.O'Donnell; CHEST Foundation Grant in COVID-192020(DMF).; To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COV...; 关键词：DISTRESS ACUTE Metab

Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma: 《Asian Journal of Andrology》2025年第1期101-112,共12页Fang-Xing Zhang Xi Chen De-Cao Niu Lang Cheng Cai-Sheng Huang Ming Liao Yu Xue Xiao-Lei Shi Zeng-Nan Mo; supported by the National Natural Science Foundation of China(No.81770759 and No.82270806);Innovation Project of Guangxi Graduate Education(No.YCBZ2022094).; Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is a complex disease that is often accompanied by mental health disorders.However,the potential mechanisms underlying the heterogeneous clinical presentation of...; 关键词：BIOMARKER chronic prostatitis/chronic pelvic pain syndrome DEPRESSION INFLAMMATION metabolomics

Metabolomic Changes in Mice Induced by Copper Exposure:Systematic Analysis and Exploration of Toxicity Mechanisms: 《Biomedical and Environmental Sciences》2025年第1期106-118,共13页Shuai Xiao Linqiang Gong Shiyuan Zhao Xue Chu Fengfeng Li Yazhou Zhang Fangqiang Song Pei Jiang Gang Ding Shuai Tang; supported by grants from the Health Commission of Weifang(No.WFWSJK-2023-155 to Q.W.);the Natural Science Foundation of Shandong Province(No.ZR2024MH147 to G.D.);the National Natural Science Foundation of China(No.81570945 to G.D.).; Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].T...; 关键词：COPPER HOMEOSTASIS thereby

Effects of aflatoxin B1 on subacute exposure of hybrid groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂):Growth,liver histology,and integrated liver transcriptome and metabolome analysis: 《Animal Nutrition》2024年第4期192-214,共23页Hao Liu Shuqing Liang Weibin Huang Yuanzhi Yang Menglong Zhou Baiquan Lu Biao Li Wenshan Cai Hengyang Song Beiping Tan Xiaohui Dong; supported financially by the Research and Demonstration of Precision Functional Compound Feed Technology of Major Cultured Fishes and Shrimps in South China,China(2021B0202050002);the Department of Education of Guangdong Province,China(2021ZDZX4005);the China Agriculture Research System of MOF and MARA,China(CARS-47).; With the increasing incorporation of plant-based ingredients into the grouper diet,the issue of aflatoxin B1 (AFB1) contamination in the diet has become a significant concern.In this study,the negative effects of AFB1...; 关键词：Aflatoxin B1 Hybrid grouper Transcriptomic METABOLOMIC LIVER

Metabolomic profiling of cerebrospinal fluid in neurosyphilis:identification of potential diagnostic biomarkers: 《皮肤性病诊疗学杂志》2024年第12期801-809,共9页HE Yuanyuan WU Jiaxin CHEN Zhaoqi DENG Ziliang WANG Haiying KE Wujian; Objective This study aims to analyze metabolites in the cerebrospinal fluid(CSF)of neurosyphilis patients to identify potential diagnostic markers.Methods Untargeted metabolomics by liquid chromatography-mass spectrom...; 关键词：NEUROSYPHILIS metabolomic profiling cerebrospinal fluid diagnostic biomarkers

Effect of exogenous free N^(ε)-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction:neuroinflammation,and metabolic disorders: 《Food Science and Human Wellness》2024年第5期2970-2981,共12页Huang Zhang Lan Mo Xi Chen Mei Li Maiquan Li Yang Xu Maomao Zeng Zhiyong He Qingwu Shen Jie Chen Wei Quan; supported by the National Natural Science Foundation of China(32302258,32172317);Changsha Municipal Natural Science Foundation(kq2202223).; Diabetes-associated cognitive dysfunction has already been attracted considerable attention.Advanced glycation end products(AGEs)from daily diets are thought to be a vital contributor to the development of this diseas...; 关键词：Diabetes Cognitive dysfunction N^(ε)-(carboxymethyl)lysine NEUROINFLAMMATION METABOLOMIC

Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons: 《Biomedical and Environmental Sciences》2024年第5期479-493,共15页LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao; partly supported by grants from the National Natural Science Foundation of China(No:81372955);BiosTime Maternal and Infant Nutrition and Health Research Fund(2017FYH008);the Projects of Medical and Health Technology Development Program in Shandong Province(No:2016WS0309);Qingdao Outstanding Health Professional Development Fund(2020-2022,2022-2024)。; Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal m...; 关键词：Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

Integrated 16S rRNA sequencing and metabolomic analysis reveals the potential protective mechanism of Germacrone on diabetic nephropathy in mice: 《Acta Biochimica et Biophysica Sinica》2024年第3期414-426,共13页Yunguang Wang Xinxin He Mengjiao Xue Huan Yu Qiang He Juan Jin; This work was supported by the grants from the Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(No.2022ZB273);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.LHDMY24H270002);the Zhejiang Provincial Medical and Health Technology Project(No.2023KY158);the Cultivation Program for Excellent Young Talents of Hangzhou First People’s Hospital(No.YQNYC202131);the Science and Technology Special Project of Hangzhou Biomedicine and Health Industry Development Support(No.2021WJCY253).; Diabetic nephropathy(DN)is a severe complication of diabetes and the leading cause of end-stage renal disease and death.Germacrone(Ger)possesses anti-inflammatory,antioxidant and anti-DN properties.However,it is uncle...; 关键词：diabetic nephropathy GERMACRONE gut microbiota untargeted fecal metabolomics 16S rRNA sequencing

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